Predictive Value of Dynamic Corneal Response Parameters Evaluated with Scheimpflug High-Speed Video (Corvis ST) on the Visual Field Progression in Prostaglandin Treated Ocular Hypertension and Open-Angle Glaucoma Patients
Abstract Introduction The aim of this work is to compare the Corvis ST stress–strain index (SSI) and highest concavity (HC) parameters at baseline and 1 month after initiating monotherapy with prostaglandin analogues (PGs) in eyes showing visual field (VF) progression or stability. Methods In this p...
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2023-09-01
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| Series: | Ophthalmology and Therapy |
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| Online Access: | https://doi.org/10.1007/s40123-023-00810-0 |
| _version_ | 1797630406246268928 |
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| author | Marta I. Martinez-Sánchez Gema Bolívar Anna Dastiridou Purificación Escámez Miguel A. Teus |
| author_facet | Marta I. Martinez-Sánchez Gema Bolívar Anna Dastiridou Purificación Escámez Miguel A. Teus |
| author_sort | Marta I. Martinez-Sánchez |
| collection | DOAJ |
| description | Abstract Introduction The aim of this work is to compare the Corvis ST stress–strain index (SSI) and highest concavity (HC) parameters at baseline and 1 month after initiating monotherapy with prostaglandin analogues (PGs) in eyes showing visual field (VF) progression or stability. Methods In this prospective, single-center, observational study, newly diagnosed and treatment-naïve OAG patients were examined at baseline and 1 month after beginning monotherapy with topical PGs monotherapy. Goldmann applanation tonometry pressure readings, Corneal Hysteresis (ORA-CH), and the Corvis ST measurements were obtained at both visits. VF progression (Humphrey) was evaluated based on data from 6 years of follow-up after the baseline visit. Stress–strain index (SSI) and HC parameters in progressing (P) and non-progressing (NP) eyes were the main outcome measures. Results Sixty-three eyes were analyzed; mean age was 64.63 ± 11.26 years; 47 eyes were NP and 16 eyes were P according to the event analysis performed by the Humphrey device. There were no significant differences in IOP, CCT, or Corvis parameters between NP and P groups at baseline. Nevertheless, at 1 month, the SSI index was 1.60 ± 0.34 vs. 1.80 ± 0.34 (p = 0.003) in NP vs. P eyes, respectively. HC parameters were different between the groups at 1 month (p < 0.05) suggesting an increased scleral rigidity in the P group. There was no significant difference in IOP between groups at 1 month. Conclusions The Corvis ST provides a corneal rigidity index (SSI) that seems to be related to VF progression when measured 1 month after initiating PGs monotherapy. Differences in HC parameters, indicative of increased scleral stiffness, are also evident at 1 month on latanoprost in the P eyes. |
| first_indexed | 2024-03-11T11:07:49Z |
| format | Article |
| id | doaj.art-c57dccc7309540f7a64862ee942403a8 |
| institution | Directory Open Access Journal |
| issn | 2193-8245 2193-6528 |
| language | English |
| last_indexed | 2024-03-11T11:07:49Z |
| publishDate | 2023-09-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Ophthalmology and Therapy |
| spelling | doaj.art-c57dccc7309540f7a64862ee942403a82023-11-12T12:09:05ZengAdis, Springer HealthcareOphthalmology and Therapy2193-82452193-65282023-09-011263177318610.1007/s40123-023-00810-0Predictive Value of Dynamic Corneal Response Parameters Evaluated with Scheimpflug High-Speed Video (Corvis ST) on the Visual Field Progression in Prostaglandin Treated Ocular Hypertension and Open-Angle Glaucoma PatientsMarta I. Martinez-Sánchez0Gema Bolívar1Anna Dastiridou2Purificación Escámez3Miguel A. Teus4Hospital Universitario “Principe de Asturias”Hospital Universitario “Principe de Asturias”Ophthalmology Department, University of ThessalyHospital Universitario “Principe de Asturias”Hospital Universitario “Principe de Asturias”Abstract Introduction The aim of this work is to compare the Corvis ST stress–strain index (SSI) and highest concavity (HC) parameters at baseline and 1 month after initiating monotherapy with prostaglandin analogues (PGs) in eyes showing visual field (VF) progression or stability. Methods In this prospective, single-center, observational study, newly diagnosed and treatment-naïve OAG patients were examined at baseline and 1 month after beginning monotherapy with topical PGs monotherapy. Goldmann applanation tonometry pressure readings, Corneal Hysteresis (ORA-CH), and the Corvis ST measurements were obtained at both visits. VF progression (Humphrey) was evaluated based on data from 6 years of follow-up after the baseline visit. Stress–strain index (SSI) and HC parameters in progressing (P) and non-progressing (NP) eyes were the main outcome measures. Results Sixty-three eyes were analyzed; mean age was 64.63 ± 11.26 years; 47 eyes were NP and 16 eyes were P according to the event analysis performed by the Humphrey device. There were no significant differences in IOP, CCT, or Corvis parameters between NP and P groups at baseline. Nevertheless, at 1 month, the SSI index was 1.60 ± 0.34 vs. 1.80 ± 0.34 (p = 0.003) in NP vs. P eyes, respectively. HC parameters were different between the groups at 1 month (p < 0.05) suggesting an increased scleral rigidity in the P group. There was no significant difference in IOP between groups at 1 month. Conclusions The Corvis ST provides a corneal rigidity index (SSI) that seems to be related to VF progression when measured 1 month after initiating PGs monotherapy. Differences in HC parameters, indicative of increased scleral stiffness, are also evident at 1 month on latanoprost in the P eyes.https://doi.org/10.1007/s40123-023-00810-0BiomechanicsCorneaGlaucomaOcular hypertensionStress–strain indexStiffness |
| spellingShingle | Marta I. Martinez-Sánchez Gema Bolívar Anna Dastiridou Purificación Escámez Miguel A. Teus Predictive Value of Dynamic Corneal Response Parameters Evaluated with Scheimpflug High-Speed Video (Corvis ST) on the Visual Field Progression in Prostaglandin Treated Ocular Hypertension and Open-Angle Glaucoma Patients Ophthalmology and Therapy Biomechanics Cornea Glaucoma Ocular hypertension Stress–strain index Stiffness |
| title | Predictive Value of Dynamic Corneal Response Parameters Evaluated with Scheimpflug High-Speed Video (Corvis ST) on the Visual Field Progression in Prostaglandin Treated Ocular Hypertension and Open-Angle Glaucoma Patients |
| title_full | Predictive Value of Dynamic Corneal Response Parameters Evaluated with Scheimpflug High-Speed Video (Corvis ST) on the Visual Field Progression in Prostaglandin Treated Ocular Hypertension and Open-Angle Glaucoma Patients |
| title_fullStr | Predictive Value of Dynamic Corneal Response Parameters Evaluated with Scheimpflug High-Speed Video (Corvis ST) on the Visual Field Progression in Prostaglandin Treated Ocular Hypertension and Open-Angle Glaucoma Patients |
| title_full_unstemmed | Predictive Value of Dynamic Corneal Response Parameters Evaluated with Scheimpflug High-Speed Video (Corvis ST) on the Visual Field Progression in Prostaglandin Treated Ocular Hypertension and Open-Angle Glaucoma Patients |
| title_short | Predictive Value of Dynamic Corneal Response Parameters Evaluated with Scheimpflug High-Speed Video (Corvis ST) on the Visual Field Progression in Prostaglandin Treated Ocular Hypertension and Open-Angle Glaucoma Patients |
| title_sort | predictive value of dynamic corneal response parameters evaluated with scheimpflug high speed video corvis st on the visual field progression in prostaglandin treated ocular hypertension and open angle glaucoma patients |
| topic | Biomechanics Cornea Glaucoma Ocular hypertension Stress–strain index Stiffness |
| url | https://doi.org/10.1007/s40123-023-00810-0 |
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