Deep Sea Water Improves Abnormalities in Lipid Metabolism through Lipolysis and Fatty Acid Oxidation in High-Fat Diet-Induced Obese Rats
Deep sea water (DSW) is a natural marine resource that has been utilized for food, agriculture, cosmetics, and medicine. The aim of this study was to investigate whether DSW has beneficial lipid metabolic effects in an animal model. Our previous in vitro study indicated that DSW significantly decrea...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-12-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/15/12/386 |
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| author | Wei-Tang Chang Tsung-Yueh Lu Ming-Ching Cheng Hsun-Chi Lu Mei-Fang Wu Chin-Lin Hsu |
| author_facet | Wei-Tang Chang Tsung-Yueh Lu Ming-Ching Cheng Hsun-Chi Lu Mei-Fang Wu Chin-Lin Hsu |
| author_sort | Wei-Tang Chang |
| collection | DOAJ |
| description | Deep sea water (DSW) is a natural marine resource that has been utilized for food, agriculture, cosmetics, and medicine. The aim of this study was to investigate whether DSW has beneficial lipid metabolic effects in an animal model. Our previous in vitro study indicated that DSW significantly decreased the intracellular triglyceride and glycerol-3-phosphate dehydrogenase activity in 3T3-L1 adipocytes. DSW also inhibited the gene levels of adipocyte differentiation, lipogenesis, and adipocytokines, and up-regulated gene levels of lipolysis and fatty acid oxidation. In the present study, the results showed that body weight, liver, adipose tissue, hepatic triglycerides and cholesterol, and serum parameters in the high-fat diet (HFD) + DSW groups were significantly lower compared to the HFD group. Moreover, the fecal output of total lipids, triglycerides, and cholesterol in the HFD + DSW groups was significantly higher than that of the HFD group. Regarding gene expression, DSW significantly increased the gene levels of lipolysis and fatty acid oxidation, and decreased the gene levels of adipocytokine in the adipose tissue of rats with HFD-induced obesity. These results indicate a potential molecular mechanism by which DSW can suppress obesity in rats with HFD-induced obesity through lipolysis and fatty acid oxidation. |
| first_indexed | 2024-04-14T06:59:28Z |
| format | Article |
| id | doaj.art-c57fe0d168a3460480fc0a9397b3839e |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T06:59:28Z |
| publishDate | 2017-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-c57fe0d168a3460480fc0a9397b3839e2022-12-22T02:06:48ZengMDPI AGMarine Drugs1660-33972017-12-01151238610.3390/md15120386md15120386Deep Sea Water Improves Abnormalities in Lipid Metabolism through Lipolysis and Fatty Acid Oxidation in High-Fat Diet-Induced Obese RatsWei-Tang Chang0Tsung-Yueh Lu1Ming-Ching Cheng2Hsun-Chi Lu3Mei-Fang Wu4Chin-Lin Hsu5School of Nutrition, Chung Shan Medical University, Taichung 404, TaiwanDepartment of Industrial Engineering and Systems Management, Feng Chia University, Taichung 404, TaiwanDepartment of Health Food, Chung Chou University of Science and Technology, Changhua 510, TaiwanSchool of Nutrition, Chung Shan Medical University, Taichung 404, TaiwanDepartment of Industrial Engineering and Systems Management, Feng Chia University, Taichung 404, TaiwanSchool of Nutrition, Chung Shan Medical University, Taichung 404, TaiwanDeep sea water (DSW) is a natural marine resource that has been utilized for food, agriculture, cosmetics, and medicine. The aim of this study was to investigate whether DSW has beneficial lipid metabolic effects in an animal model. Our previous in vitro study indicated that DSW significantly decreased the intracellular triglyceride and glycerol-3-phosphate dehydrogenase activity in 3T3-L1 adipocytes. DSW also inhibited the gene levels of adipocyte differentiation, lipogenesis, and adipocytokines, and up-regulated gene levels of lipolysis and fatty acid oxidation. In the present study, the results showed that body weight, liver, adipose tissue, hepatic triglycerides and cholesterol, and serum parameters in the high-fat diet (HFD) + DSW groups were significantly lower compared to the HFD group. Moreover, the fecal output of total lipids, triglycerides, and cholesterol in the HFD + DSW groups was significantly higher than that of the HFD group. Regarding gene expression, DSW significantly increased the gene levels of lipolysis and fatty acid oxidation, and decreased the gene levels of adipocytokine in the adipose tissue of rats with HFD-induced obesity. These results indicate a potential molecular mechanism by which DSW can suppress obesity in rats with HFD-induced obesity through lipolysis and fatty acid oxidation.https://www.mdpi.com/1660-3397/15/12/386deep sea waterhigh fat-dietWistar ratgene expression |
| spellingShingle | Wei-Tang Chang Tsung-Yueh Lu Ming-Ching Cheng Hsun-Chi Lu Mei-Fang Wu Chin-Lin Hsu Deep Sea Water Improves Abnormalities in Lipid Metabolism through Lipolysis and Fatty Acid Oxidation in High-Fat Diet-Induced Obese Rats Marine Drugs deep sea water high fat-diet Wistar rat gene expression |
| title | Deep Sea Water Improves Abnormalities in Lipid Metabolism through Lipolysis and Fatty Acid Oxidation in High-Fat Diet-Induced Obese Rats |
| title_full | Deep Sea Water Improves Abnormalities in Lipid Metabolism through Lipolysis and Fatty Acid Oxidation in High-Fat Diet-Induced Obese Rats |
| title_fullStr | Deep Sea Water Improves Abnormalities in Lipid Metabolism through Lipolysis and Fatty Acid Oxidation in High-Fat Diet-Induced Obese Rats |
| title_full_unstemmed | Deep Sea Water Improves Abnormalities in Lipid Metabolism through Lipolysis and Fatty Acid Oxidation in High-Fat Diet-Induced Obese Rats |
| title_short | Deep Sea Water Improves Abnormalities in Lipid Metabolism through Lipolysis and Fatty Acid Oxidation in High-Fat Diet-Induced Obese Rats |
| title_sort | deep sea water improves abnormalities in lipid metabolism through lipolysis and fatty acid oxidation in high fat diet induced obese rats |
| topic | deep sea water high fat-diet Wistar rat gene expression |
| url | https://www.mdpi.com/1660-3397/15/12/386 |
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