HeGRI: A Novel Index of Serum Hepcidin Suppression in Relation to the Degree of Renal Dysfunction among β-Thalassemia Major Patients
<b>Background:</b> The progressive renal function inadequacy results in altered hepcidin metabolism due to a shifting of its renal elimination, which consequently affects enteric iron absorption and iron stores’ availability. This study aimed to investigate and correlate renal function,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Thalassemia Reports |
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| Online Access: | https://www.mdpi.com/2039-4365/12/1/2 |
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| author | Burhan A. Zaman Suzan O. Rasool Nashwan M. R. Ibrahim Deldar M. Abdulah |
| author_facet | Burhan A. Zaman Suzan O. Rasool Nashwan M. R. Ibrahim Deldar M. Abdulah |
| author_sort | Burhan A. Zaman |
| collection | DOAJ |
| description | <b>Background:</b> The progressive renal function inadequacy results in altered hepcidin metabolism due to a shifting of its renal elimination, which consequently affects enteric iron absorption and iron stores’ availability. This study aimed to investigate and correlate renal function, iron status, and hepcidin in patients with β-thalassemia major through a novel index. <b>Methods:</b> In this 1:1 case–control study, serum hepcidin, serum ferritin, iron study, hematological and renal function parameters were compared between 60 β-thalassemia major patients with iron overload and 61 healthy individuals (2–30 years old). <b>Results:</b> The concentrations of serum hepcidin (21.898 vs. 9.941 ng/mL; <i>p</i> < 0.001) and eGFR (179.71 vs. 132.95; <i>p</i> < 0.001) were significantly higher in β-thalassemia major patients compared to the controls. The serum hepcidin levels decreased with increasing levels of total iron-binding capacity (TIBC; β = −0.442; <i>p</i> = 0.024), transferrin saturation (β = −0.343; <i>p</i> = 0.023), serum creatinine (β = −0.625; <i>p</i> = 0.0030), and eGFR (β = −0.496; <i>p</i> = 0.011). The mean hepcidin/ferritin ratio was significantly lower in the β-thalassemia major cases (0.0069 vs. 0.3970; <i>p</i> < 0.001). The novel hepcidin/eGFR ratio index (HeGRI) was significantly higher in the patient group compared to controls (0.12 vs. 0.09; <i>p</i> = 0.031), respectively. <b>Conclusions:</b> These results suggest that HeGRI could be a potential index of the appropriateness of serum hepcidin suppression associated with the degree of renal dysfunction among β-thalassemia major patients. |
| first_indexed | 2024-03-09T12:24:06Z |
| format | Article |
| id | doaj.art-c5801ff23e2d4b22ad1887e2ecaccd78 |
| institution | Directory Open Access Journal |
| issn | 2039-4365 |
| language | English |
| last_indexed | 2024-03-09T12:24:06Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
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| series | Thalassemia Reports |
| spelling | doaj.art-c5801ff23e2d4b22ad1887e2ecaccd782023-11-30T22:37:45ZengMDPI AGThalassemia Reports2039-43652021-12-0112121110.3390/thalassrep12010002HeGRI: A Novel Index of Serum Hepcidin Suppression in Relation to the Degree of Renal Dysfunction among β-Thalassemia Major PatientsBurhan A. Zaman0Suzan O. Rasool1Nashwan M. R. Ibrahim2Deldar M. Abdulah3Department of Basic Sciences, College of Pharmacy, University of Duhok, Duhok City 42001, Kurdistan Region, IraqDepartment of Clinical Pharmacy, College of Pharmacy, University of Duhok, Duhok City 42001, Kurdistan Region, IraqDepartment of Surgery, College of Medicine, University of Duhok, Duhok City 42001, Kurdistan Region, IraqCommunity and Maternity Health Unit, College of Nursing, University of Duhok, Duhok City 42001, Kurdistan Region, Iraq<b>Background:</b> The progressive renal function inadequacy results in altered hepcidin metabolism due to a shifting of its renal elimination, which consequently affects enteric iron absorption and iron stores’ availability. This study aimed to investigate and correlate renal function, iron status, and hepcidin in patients with β-thalassemia major through a novel index. <b>Methods:</b> In this 1:1 case–control study, serum hepcidin, serum ferritin, iron study, hematological and renal function parameters were compared between 60 β-thalassemia major patients with iron overload and 61 healthy individuals (2–30 years old). <b>Results:</b> The concentrations of serum hepcidin (21.898 vs. 9.941 ng/mL; <i>p</i> < 0.001) and eGFR (179.71 vs. 132.95; <i>p</i> < 0.001) were significantly higher in β-thalassemia major patients compared to the controls. The serum hepcidin levels decreased with increasing levels of total iron-binding capacity (TIBC; β = −0.442; <i>p</i> = 0.024), transferrin saturation (β = −0.343; <i>p</i> = 0.023), serum creatinine (β = −0.625; <i>p</i> = 0.0030), and eGFR (β = −0.496; <i>p</i> = 0.011). The mean hepcidin/ferritin ratio was significantly lower in the β-thalassemia major cases (0.0069 vs. 0.3970; <i>p</i> < 0.001). The novel hepcidin/eGFR ratio index (HeGRI) was significantly higher in the patient group compared to controls (0.12 vs. 0.09; <i>p</i> = 0.031), respectively. <b>Conclusions:</b> These results suggest that HeGRI could be a potential index of the appropriateness of serum hepcidin suppression associated with the degree of renal dysfunction among β-thalassemia major patients.https://www.mdpi.com/2039-4365/12/1/2hepcidineGFRrenal dysfunctioniron overloadβ-thalassemia major |
| spellingShingle | Burhan A. Zaman Suzan O. Rasool Nashwan M. R. Ibrahim Deldar M. Abdulah HeGRI: A Novel Index of Serum Hepcidin Suppression in Relation to the Degree of Renal Dysfunction among β-Thalassemia Major Patients Thalassemia Reports hepcidin eGFR renal dysfunction iron overload β-thalassemia major |
| title | HeGRI: A Novel Index of Serum Hepcidin Suppression in Relation to the Degree of Renal Dysfunction among β-Thalassemia Major Patients |
| title_full | HeGRI: A Novel Index of Serum Hepcidin Suppression in Relation to the Degree of Renal Dysfunction among β-Thalassemia Major Patients |
| title_fullStr | HeGRI: A Novel Index of Serum Hepcidin Suppression in Relation to the Degree of Renal Dysfunction among β-Thalassemia Major Patients |
| title_full_unstemmed | HeGRI: A Novel Index of Serum Hepcidin Suppression in Relation to the Degree of Renal Dysfunction among β-Thalassemia Major Patients |
| title_short | HeGRI: A Novel Index of Serum Hepcidin Suppression in Relation to the Degree of Renal Dysfunction among β-Thalassemia Major Patients |
| title_sort | hegri a novel index of serum hepcidin suppression in relation to the degree of renal dysfunction among β thalassemia major patients |
| topic | hepcidin eGFR renal dysfunction iron overload β-thalassemia major |
| url | https://www.mdpi.com/2039-4365/12/1/2 |
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