Palmitic and Stearic Acids Inhibit Chaperone-Mediated Autophagy (CMA) in POMC-like Neurons In Vitro

Palmitic and Stearic Acids Inhibit Chaperone-Mediated Autophagy (CMA) in POMC-like Neurons In Vitro

The intake of food with high levels of saturated fatty acids (SatFAs) is associated with the development of obesity and insulin resistance. SatFAs, such as palmitic (PA) and stearic (SA) acids, have been shown to accumulate in the hypothalamus, causing several pathological consequences. Autophagy is...

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Bibliographic Details
Main Authors: Rodrigo Espinosa, Karla Gutiérrez, Javiera Rios, Fernando Ormeño, Liliana Yantén, Pablo Galaz-Davison, César A. Ramírez-Sarmiento, Valentina Parra, Amelina Albornoz, Iván E. Alfaro, Patricia V. Burgos, Eugenia Morselli, Alfredo Criollo, Mauricio Budini
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
chaperone-mediated autophagy (CMA)
insulin
palmitic
stearic
lysosome
obesity
Online Access:https://www.mdpi.com/2073-4409/11/6/920

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