Clinicopathological features and survival of colorectal cancer patients younger than 50 years: a retrospective comparative study
Abstract Background Colorectal cancer (CRC) is a disease of old age, but its incidence has been rising among younger population compared to older ones. Nevertheless, there is a controversy over survival of younger patients compared to the older ones. Therefore, in the current study, we investigated...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2019-11-01
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| Series: | Journal of the Egyptian National Cancer Institute |
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| Online Access: | https://doi.org/10.1186/s43046-019-0006-z |
| _version_ | 1828884119829872640 |
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| author | Robabeh Ghodssi-Ghassemabadi Ebrahim Hajizadeh Shaghayegh Kamian Mahmood Mahmoudi |
| author_facet | Robabeh Ghodssi-Ghassemabadi Ebrahim Hajizadeh Shaghayegh Kamian Mahmood Mahmoudi |
| author_sort | Robabeh Ghodssi-Ghassemabadi |
| collection | DOAJ |
| description | Abstract Background Colorectal cancer (CRC) is a disease of old age, but its incidence has been rising among younger population compared to older ones. Nevertheless, there is a controversy over survival of younger patients compared to the older ones. Therefore, in the current study, we investigated the clinicopathological features and survival of the younger (< 50 years) versus older (≥ 50 years) CRC patients. Results The younger and older groups consisted of 39.4% and 60.6% of patients, respectively. Both age groups were comparable regarding the symptom presentation and duration, and pre-operative carcinoembryonic antigen (CEA). The younger patients were diagnosed with a higher proportion of poorly differentiated (14.7% vs. 8.3%; p < 0.001) and more advanced tumors (53.2% vs. 45.9%; p = 0.266). The rectum tumor site was significantly more common among the younger patients (p = 0.021). The overall survival (OS) (p = 0.278), the cancer-specific survival (CSS) (p = 0.233), and the disease-free survival (DFS) (p = 0.497) did not differ significantly between the two groups. Based on Cox regression model, elevated pre-operative CEA level (HR = 1.41; 95%CI of 1.01–1.97), advanced tumor stage (6.06; 95%CI of 3.03–12.15), and poorly differentiated tumor (HR = 1.69; 95%CI of 1.05–2.71) were associated with decreased survival. Conclusions The younger patients did not have poor prognosis compared to the older ones despite having an advanced tumor stage and a poor tumor differentiation. |
| first_indexed | 2024-12-13T11:02:08Z |
| format | Article |
| id | doaj.art-c5859920c0d542329711849887dc6a9b |
| institution | Directory Open Access Journal |
| issn | 2589-0409 |
| language | English |
| last_indexed | 2024-12-13T11:02:08Z |
| publishDate | 2019-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of the Egyptian National Cancer Institute |
| spelling | doaj.art-c5859920c0d542329711849887dc6a9b2022-12-21T23:49:14ZengSpringerOpenJournal of the Egyptian National Cancer Institute2589-04092019-11-013111910.1186/s43046-019-0006-zClinicopathological features and survival of colorectal cancer patients younger than 50 years: a retrospective comparative studyRobabeh Ghodssi-Ghassemabadi0Ebrahim Hajizadeh1Shaghayegh Kamian2Mahmood Mahmoudi3Department of Biostatistics, School of Medical Sciences, Tarbiat Modares UniversityDepartment of Biostatistics, School of Medical Sciences, Tarbiat Modares UniversityShahid Beheshti University of Medical Sciences, Imam Hossein HospitalDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical SciencesAbstract Background Colorectal cancer (CRC) is a disease of old age, but its incidence has been rising among younger population compared to older ones. Nevertheless, there is a controversy over survival of younger patients compared to the older ones. Therefore, in the current study, we investigated the clinicopathological features and survival of the younger (< 50 years) versus older (≥ 50 years) CRC patients. Results The younger and older groups consisted of 39.4% and 60.6% of patients, respectively. Both age groups were comparable regarding the symptom presentation and duration, and pre-operative carcinoembryonic antigen (CEA). The younger patients were diagnosed with a higher proportion of poorly differentiated (14.7% vs. 8.3%; p < 0.001) and more advanced tumors (53.2% vs. 45.9%; p = 0.266). The rectum tumor site was significantly more common among the younger patients (p = 0.021). The overall survival (OS) (p = 0.278), the cancer-specific survival (CSS) (p = 0.233), and the disease-free survival (DFS) (p = 0.497) did not differ significantly between the two groups. Based on Cox regression model, elevated pre-operative CEA level (HR = 1.41; 95%CI of 1.01–1.97), advanced tumor stage (6.06; 95%CI of 3.03–12.15), and poorly differentiated tumor (HR = 1.69; 95%CI of 1.05–2.71) were associated with decreased survival. Conclusions The younger patients did not have poor prognosis compared to the older ones despite having an advanced tumor stage and a poor tumor differentiation.https://doi.org/10.1186/s43046-019-0006-zSurvivalColorectal cancerYoung patientsCarcinoembryonic antigen (CEA)Tumor stage |
| spellingShingle | Robabeh Ghodssi-Ghassemabadi Ebrahim Hajizadeh Shaghayegh Kamian Mahmood Mahmoudi Clinicopathological features and survival of colorectal cancer patients younger than 50 years: a retrospective comparative study Journal of the Egyptian National Cancer Institute Survival Colorectal cancer Young patients Carcinoembryonic antigen (CEA) Tumor stage |
| title | Clinicopathological features and survival of colorectal cancer patients younger than 50 years: a retrospective comparative study |
| title_full | Clinicopathological features and survival of colorectal cancer patients younger than 50 years: a retrospective comparative study |
| title_fullStr | Clinicopathological features and survival of colorectal cancer patients younger than 50 years: a retrospective comparative study |
| title_full_unstemmed | Clinicopathological features and survival of colorectal cancer patients younger than 50 years: a retrospective comparative study |
| title_short | Clinicopathological features and survival of colorectal cancer patients younger than 50 years: a retrospective comparative study |
| title_sort | clinicopathological features and survival of colorectal cancer patients younger than 50 years a retrospective comparative study |
| topic | Survival Colorectal cancer Young patients Carcinoembryonic antigen (CEA) Tumor stage |
| url | https://doi.org/10.1186/s43046-019-0006-z |
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