Contact lens as an emerging platform for ophthalmic drug delivery: A systematic review
The number of people with eye diseases has increased with the use of electronics. However, the bioavailability of eye drops remains low owing to the presence of the ocular barrier and other reasons. Although many drug delivery systems have been developed to overcome these problems, they have certain...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-09-01
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| Series: | Asian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087623000740 |
| _version_ | 1797631077567692800 |
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| author | Hongyu Yang Ming Zhao Dandan Xing Jian Zhang Ting Fang Faxing Zhang Zhihao Nie Yaming Liu Lihua Yang Ji Li Dongkai Wang |
| author_facet | Hongyu Yang Ming Zhao Dandan Xing Jian Zhang Ting Fang Faxing Zhang Zhihao Nie Yaming Liu Lihua Yang Ji Li Dongkai Wang |
| author_sort | Hongyu Yang |
| collection | DOAJ |
| description | The number of people with eye diseases has increased with the use of electronics. However, the bioavailability of eye drops remains low owing to the presence of the ocular barrier and other reasons. Although many drug delivery systems have been developed to overcome these problems, they have certain limitations. In recent years, the development of contact lenses that can deliver drugs for long periods with high bioavailability and without affecting vision has increased the interest in using contact lenses for drug delivery. Hence, a review of the current state of research on drug delivery contact lenses has become crucial. This article reviews the key physical and chemical properties of drug-laden contact lenses, development and classification of contact lenses, and features of the commonly used materials. A review of the methods commonly used in current research to create contact lenses has also been presented. An overview on how drug-laden contact lenses can overcome the problems of high burst and short release duration has been discussed. Overall, the review focuses on drug delivery methods using smart contact lenses, and predicts the future direction of research on contact lenses. |
| first_indexed | 2024-03-11T11:15:49Z |
| format | Article |
| id | doaj.art-c589d367fa874468af0f3ee5a6ea9878 |
| institution | Directory Open Access Journal |
| issn | 1818-0876 |
| language | English |
| last_indexed | 2024-03-11T11:15:49Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-c589d367fa874468af0f3ee5a6ea98782023-11-11T04:27:52ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762023-09-01185100847Contact lens as an emerging platform for ophthalmic drug delivery: A systematic reviewHongyu Yang0Ming Zhao1Dandan Xing2Jian Zhang3Ting Fang4Faxing Zhang5Zhihao Nie6Yaming Liu7Lihua Yang8Ji Li9Dongkai Wang10Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaCorresponding authors.; Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaCorresponding authors.; Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaThe number of people with eye diseases has increased with the use of electronics. However, the bioavailability of eye drops remains low owing to the presence of the ocular barrier and other reasons. Although many drug delivery systems have been developed to overcome these problems, they have certain limitations. In recent years, the development of contact lenses that can deliver drugs for long periods with high bioavailability and without affecting vision has increased the interest in using contact lenses for drug delivery. Hence, a review of the current state of research on drug delivery contact lenses has become crucial. This article reviews the key physical and chemical properties of drug-laden contact lenses, development and classification of contact lenses, and features of the commonly used materials. A review of the methods commonly used in current research to create contact lenses has also been presented. An overview on how drug-laden contact lenses can overcome the problems of high burst and short release duration has been discussed. Overall, the review focuses on drug delivery methods using smart contact lenses, and predicts the future direction of research on contact lenses.http://www.sciencedirect.com/science/article/pii/S1818087623000740Drug-loaded contact lensesDrug-loaded smart contact lensesCorneal diseasesOcular drug deliveryKey attributes of contact lenses |
| spellingShingle | Hongyu Yang Ming Zhao Dandan Xing Jian Zhang Ting Fang Faxing Zhang Zhihao Nie Yaming Liu Lihua Yang Ji Li Dongkai Wang Contact lens as an emerging platform for ophthalmic drug delivery: A systematic review Asian Journal of Pharmaceutical Sciences Drug-loaded contact lenses Drug-loaded smart contact lenses Corneal diseases Ocular drug delivery Key attributes of contact lenses |
| title | Contact lens as an emerging platform for ophthalmic drug delivery: A systematic review |
| title_full | Contact lens as an emerging platform for ophthalmic drug delivery: A systematic review |
| title_fullStr | Contact lens as an emerging platform for ophthalmic drug delivery: A systematic review |
| title_full_unstemmed | Contact lens as an emerging platform for ophthalmic drug delivery: A systematic review |
| title_short | Contact lens as an emerging platform for ophthalmic drug delivery: A systematic review |
| title_sort | contact lens as an emerging platform for ophthalmic drug delivery a systematic review |
| topic | Drug-loaded contact lenses Drug-loaded smart contact lenses Corneal diseases Ocular drug delivery Key attributes of contact lenses |
| url | http://www.sciencedirect.com/science/article/pii/S1818087623000740 |
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