The Gut Microbiome and Sex Hormone-Related Diseases
The role of the gut microbiome has been a hot topic in recent years. One aim of this review is to shed light on the crosstalk between sex hormones and the gut microbiome. Researchers have observed a sex bias of the composition of the gut microbiome in mice and have proved that sex differences influe...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.711137/full |
| _version_ | 1819147786332930048 |
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| author | Song He Hao Li Zehui Yu Faming Zhang Sicheng Liang Hang Liu Hongwei Chen MuHan Lü |
| author_facet | Song He Hao Li Zehui Yu Faming Zhang Sicheng Liang Hang Liu Hongwei Chen MuHan Lü |
| author_sort | Song He |
| collection | DOAJ |
| description | The role of the gut microbiome has been a hot topic in recent years. One aim of this review is to shed light on the crosstalk between sex hormones and the gut microbiome. Researchers have observed a sex bias of the composition of the gut microbiome in mice and have proved that sex differences influence the composition of the gut microbiome, although the influence is usually obscured by genetic variations. Via cell studies, animal studies and some observational studies in humans, researchers have confirmed that the gut microbiome can be shaped by the hormonal environment. On other hand, some theories suggest that the gut microbiota regulates the levels of sex hormones via interactions among its metabolites, the immune system, chronic inflammation and some nerve-endocrine axes, such as the gut-brain axis. In addition, bidirectional interactions between the microbiome and the hormonal system have also been observed, and the mechanisms of these interactions are being explored. We further describe the role of the gut microbiome in sex hormone-related diseases, such as ovarian cancer, postmenopausal osteoporosis (PMOP), polycystic ovary syndrome and type 1 diabetes. Among these diseases, PMOP is described in detail. Finally, we discuss the treatments of these diseases and the application prospects of microbial intervention. |
| first_indexed | 2024-12-22T13:35:21Z |
| format | Article |
| id | doaj.art-c58a0e3237294bafa3acd0e458e76d60 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-22T13:35:21Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-c58a0e3237294bafa3acd0e458e76d602022-12-21T18:24:05ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-09-011210.3389/fmicb.2021.711137711137The Gut Microbiome and Sex Hormone-Related DiseasesSong He0Hao Li1Zehui Yu2Faming Zhang3Sicheng Liang4Hang Liu5Hongwei Chen6MuHan Lü7The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaThe Affiliated Hospital of Southwest Medical University, Luzhou, ChinaThe Affiliated Hospital of Southwest Medical University, Luzhou, ChinaThe Second Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaThe Affiliated Hospital of Southwest Medical University, Luzhou, ChinaThe Affiliated Hospital of Southwest Medical University, Luzhou, ChinaThe Affiliated Hospital of Southwest Medical University, Luzhou, ChinaThe Affiliated Hospital of Southwest Medical University, Luzhou, ChinaThe role of the gut microbiome has been a hot topic in recent years. One aim of this review is to shed light on the crosstalk between sex hormones and the gut microbiome. Researchers have observed a sex bias of the composition of the gut microbiome in mice and have proved that sex differences influence the composition of the gut microbiome, although the influence is usually obscured by genetic variations. Via cell studies, animal studies and some observational studies in humans, researchers have confirmed that the gut microbiome can be shaped by the hormonal environment. On other hand, some theories suggest that the gut microbiota regulates the levels of sex hormones via interactions among its metabolites, the immune system, chronic inflammation and some nerve-endocrine axes, such as the gut-brain axis. In addition, bidirectional interactions between the microbiome and the hormonal system have also been observed, and the mechanisms of these interactions are being explored. We further describe the role of the gut microbiome in sex hormone-related diseases, such as ovarian cancer, postmenopausal osteoporosis (PMOP), polycystic ovary syndrome and type 1 diabetes. Among these diseases, PMOP is described in detail. Finally, we discuss the treatments of these diseases and the application prospects of microbial intervention.https://www.frontiersin.org/articles/10.3389/fmicb.2021.711137/fullgut microbiomesex hormonessex hormone-related diseasespathogenesisgut microbial treatment |
| spellingShingle | Song He Hao Li Zehui Yu Faming Zhang Sicheng Liang Hang Liu Hongwei Chen MuHan Lü The Gut Microbiome and Sex Hormone-Related Diseases Frontiers in Microbiology gut microbiome sex hormones sex hormone-related diseases pathogenesis gut microbial treatment |
| title | The Gut Microbiome and Sex Hormone-Related Diseases |
| title_full | The Gut Microbiome and Sex Hormone-Related Diseases |
| title_fullStr | The Gut Microbiome and Sex Hormone-Related Diseases |
| title_full_unstemmed | The Gut Microbiome and Sex Hormone-Related Diseases |
| title_short | The Gut Microbiome and Sex Hormone-Related Diseases |
| title_sort | gut microbiome and sex hormone related diseases |
| topic | gut microbiome sex hormones sex hormone-related diseases pathogenesis gut microbial treatment |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2021.711137/full |
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