Combined early palliative care for non-small-cell lung cancer patients: a randomized controlled trial in Chongqing, China
PurposeMore effective approaches are needed to improve the prognosis of non-small-cell lung cancer (NSCLC) patients. Thus, we used the E-warm model to assess how early integration of interdisciplinary palliative care was related to the quality of life (QoL), psychological functioning, pain managemen...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1184961/full |
| _version_ | 1797685323874959360 |
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| author | Mengting Chen Huiqing Yu Huiqing Yu Liejun Yang Hong Yang Haoyang Cao Lei Lei Liling Ma Shihong Liu Ling Tian Sixiong Wang |
| author_facet | Mengting Chen Huiqing Yu Huiqing Yu Liejun Yang Hong Yang Haoyang Cao Lei Lei Liling Ma Shihong Liu Ling Tian Sixiong Wang |
| author_sort | Mengting Chen |
| collection | DOAJ |
| description | PurposeMore effective approaches are needed to improve the prognosis of non-small-cell lung cancer (NSCLC) patients. Thus, we used the E-warm model to assess how early integration of interdisciplinary palliative care was related to the quality of life (QoL), psychological functioning, pain management, and nutrition factors of NSCLC patients.MethodsThis randomized controlled trial enrolled 280 newly diagnosed NSCLC patients, which were randomly divided (1:1) into combined early palliative care (CEPC) and standard oncological care (SC) groups. At baseline and after 24 weeks, the Functional Assessment of Cancer Therapy-Lung (FACT-L) scale, Hospital Anxiety and Depression Scale (HADS), and the Patient Health Questionnaire-9 (PHQ-9) were used to assess QoL and psychological function, respectively. The Numerical Rating Scale (NRS) and Patient-Generated Subjective Global Assessment (PG-SGA) were used to assess cancer patients’ pain and nutrition levels. The primary outcome was overall survival (OS). Secondary outcomes comprised changes in the QoL, psychological functioning, pain, and nutrition state. The intention-to-treat method was applied for analysis. This study was registered at www.chictr.org.cn (ChiCTR2200062617).ResultsOf the 140 patients enrolled in the CEPC and SC groups, 102 and 82 completed the research. The CEPC group presented higher QoL than the SC group (p < 0.05). Additionally, fewer patients presented depressive symptoms in the CEPC group than in the SC group (p < 0.05), as well as better nutritional status (p = 0.007) and pain management (p = 0.003). Compared to the SC group, CEPC patients had significantly longer OS (20.4 vs. 24.6 months, p = 0.042; HR: 0.19; 95% CI: 0.04-0.85, p = 0.029).ConclusionWith combined early palliative care, NSCLC patients lived longer, had better QoL, were psychologically stable, were in less pain, and were more nutritionally satisfied. |
| first_indexed | 2024-03-12T00:43:30Z |
| format | Article |
| id | doaj.art-c58a4909089c41bcb13d0ec3cc7d57fe |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-12T00:43:30Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj.art-c58a4909089c41bcb13d0ec3cc7d57fe2023-09-15T01:27:12ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-09-011310.3389/fonc.2023.11849611184961Combined early palliative care for non-small-cell lung cancer patients: a randomized controlled trial in Chongqing, ChinaMengting Chen0Huiqing Yu1Huiqing Yu2Liejun Yang3Hong Yang4Haoyang Cao5Lei Lei6Liling Ma7Shihong Liu8Ling Tian9Sixiong Wang10Department of Clinical Nutrition, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Clinical Nutrition, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Geriatric Oncology and Department of Palliative Care, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Geriatric Oncology and Department of Palliative Care, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Geriatric Oncology and Department of Palliative Care, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Clinical Nutrition, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Geriatric Oncology and Department of Palliative Care, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Geriatric Oncology and Department of Palliative Care, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Geriatric Oncology and Department of Palliative Care, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Geriatric Oncology and Department of Palliative Care, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Geriatric Oncology and Department of Palliative Care, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, ChinaPurposeMore effective approaches are needed to improve the prognosis of non-small-cell lung cancer (NSCLC) patients. Thus, we used the E-warm model to assess how early integration of interdisciplinary palliative care was related to the quality of life (QoL), psychological functioning, pain management, and nutrition factors of NSCLC patients.MethodsThis randomized controlled trial enrolled 280 newly diagnosed NSCLC patients, which were randomly divided (1:1) into combined early palliative care (CEPC) and standard oncological care (SC) groups. At baseline and after 24 weeks, the Functional Assessment of Cancer Therapy-Lung (FACT-L) scale, Hospital Anxiety and Depression Scale (HADS), and the Patient Health Questionnaire-9 (PHQ-9) were used to assess QoL and psychological function, respectively. The Numerical Rating Scale (NRS) and Patient-Generated Subjective Global Assessment (PG-SGA) were used to assess cancer patients’ pain and nutrition levels. The primary outcome was overall survival (OS). Secondary outcomes comprised changes in the QoL, psychological functioning, pain, and nutrition state. The intention-to-treat method was applied for analysis. This study was registered at www.chictr.org.cn (ChiCTR2200062617).ResultsOf the 140 patients enrolled in the CEPC and SC groups, 102 and 82 completed the research. The CEPC group presented higher QoL than the SC group (p < 0.05). Additionally, fewer patients presented depressive symptoms in the CEPC group than in the SC group (p < 0.05), as well as better nutritional status (p = 0.007) and pain management (p = 0.003). Compared to the SC group, CEPC patients had significantly longer OS (20.4 vs. 24.6 months, p = 0.042; HR: 0.19; 95% CI: 0.04-0.85, p = 0.029).ConclusionWith combined early palliative care, NSCLC patients lived longer, had better QoL, were psychologically stable, were in less pain, and were more nutritionally satisfied.https://www.frontiersin.org/articles/10.3389/fonc.2023.1184961/fullcombined early palliative carenon-small-cell lung cancer (NLSCLC)overall survival (OS)pain management (MeSH)psychological statusnutritional level |
| spellingShingle | Mengting Chen Huiqing Yu Huiqing Yu Liejun Yang Hong Yang Haoyang Cao Lei Lei Liling Ma Shihong Liu Ling Tian Sixiong Wang Combined early palliative care for non-small-cell lung cancer patients: a randomized controlled trial in Chongqing, China Frontiers in Oncology combined early palliative care non-small-cell lung cancer (NLSCLC) overall survival (OS) pain management (MeSH) psychological status nutritional level |
| title | Combined early palliative care for non-small-cell lung cancer patients: a randomized controlled trial in Chongqing, China |
| title_full | Combined early palliative care for non-small-cell lung cancer patients: a randomized controlled trial in Chongqing, China |
| title_fullStr | Combined early palliative care for non-small-cell lung cancer patients: a randomized controlled trial in Chongqing, China |
| title_full_unstemmed | Combined early palliative care for non-small-cell lung cancer patients: a randomized controlled trial in Chongqing, China |
| title_short | Combined early palliative care for non-small-cell lung cancer patients: a randomized controlled trial in Chongqing, China |
| title_sort | combined early palliative care for non small cell lung cancer patients a randomized controlled trial in chongqing china |
| topic | combined early palliative care non-small-cell lung cancer (NLSCLC) overall survival (OS) pain management (MeSH) psychological status nutritional level |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1184961/full |
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