Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent

Sensitive, biocompatible and stable contrast agents for MRI are in demand. Here, the authors combine gadolinium ions with amorphous calcium carbonate to make stable paramagnetic amorphous carbonate nanoclusters with high MRI contrast and significantly improved biocompatibility over commercial gadoli...

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Bibliographic Details
Main Authors: Liang Dong, Yun-Jun Xu, Cong Sui, Yang Zhao, Li-Bo Mao, Denis Gebauer, Rose Rosenberg, Jonathan Avaro, Ya-Dong Wu, Huai-Ling Gao, Zhao Pan, Hui-Qin Wen, Xu Yan, Fei Li, Yang Lu, Helmut Cölfen, Shu-Hong Yu
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32615-3
Description
Summary:Sensitive, biocompatible and stable contrast agents for MRI are in demand. Here, the authors combine gadolinium ions with amorphous calcium carbonate to make stable paramagnetic amorphous carbonate nanoclusters with high MRI contrast and significantly improved biocompatibility over commercial gadolinium-based agents.
ISSN:2041-1723