Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent
Sensitive, biocompatible and stable contrast agents for MRI are in demand. Here, the authors combine gadolinium ions with amorphous calcium carbonate to make stable paramagnetic amorphous carbonate nanoclusters with high MRI contrast and significantly improved biocompatibility over commercial gadoli...
Main Authors: | , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
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Nature Portfolio
2022-08-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-32615-3 |
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author | Liang Dong Yun-Jun Xu Cong Sui Yang Zhao Li-Bo Mao Denis Gebauer Rose Rosenberg Jonathan Avaro Ya-Dong Wu Huai-Ling Gao Zhao Pan Hui-Qin Wen Xu Yan Fei Li Yang Lu Helmut Cölfen Shu-Hong Yu |
author_facet | Liang Dong Yun-Jun Xu Cong Sui Yang Zhao Li-Bo Mao Denis Gebauer Rose Rosenberg Jonathan Avaro Ya-Dong Wu Huai-Ling Gao Zhao Pan Hui-Qin Wen Xu Yan Fei Li Yang Lu Helmut Cölfen Shu-Hong Yu |
author_sort | Liang Dong |
collection | DOAJ |
description | Sensitive, biocompatible and stable contrast agents for MRI are in demand. Here, the authors combine gadolinium ions with amorphous calcium carbonate to make stable paramagnetic amorphous carbonate nanoclusters with high MRI contrast and significantly improved biocompatibility over commercial gadolinium-based agents. |
first_indexed | 2024-04-12T23:27:26Z |
format | Article |
id | doaj.art-c58f0ad421bb4b8f9587212ba1ec7b03 |
institution | Directory Open Access Journal |
issn | 2041-1723 |
language | English |
last_indexed | 2024-04-12T23:27:26Z |
publishDate | 2022-08-01 |
publisher | Nature Portfolio |
record_format | Article |
series | Nature Communications |
spelling | doaj.art-c58f0ad421bb4b8f9587212ba1ec7b032022-12-22T03:12:23ZengNature PortfolioNature Communications2041-17232022-08-0113111310.1038/s41467-022-32615-3Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agentLiang Dong0Yun-Jun Xu1Cong Sui2Yang Zhao3Li-Bo Mao4Denis Gebauer5Rose Rosenberg6Jonathan Avaro7Ya-Dong Wu8Huai-Ling Gao9Zhao Pan10Hui-Qin Wen11Xu Yan12Fei Li13Yang Lu14Helmut Cölfen15Shu-Hong Yu16Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, University of Science and Technology of ChinaDepartment of Radiology, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of ChinaDepartment of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, University of Science and Technology of ChinaDepartment of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, University of Science and Technology of ChinaDepartment of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, University of Science and Technology of ChinaInstitute of Inorganic Chemistry, Leibniz Universität HannoverPhysical Chemistry, Department of Chemistry, University of KonstanzScientist - Center for X-ray Analytics, Empa - Swiss Federal Laboratories for Materials Science and TechnologyAnhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of TechnologyDepartment of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, University of Science and Technology of ChinaDepartment of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, University of Science and Technology of ChinaDepartment of Blood Transfusion, The First Affiliated Hospital of Anhui Medical UniversityAnhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of TechnologyAnhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of TechnologyAnhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of TechnologyPhysical Chemistry, Department of Chemistry, University of KonstanzDepartment of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, University of Science and Technology of ChinaSensitive, biocompatible and stable contrast agents for MRI are in demand. Here, the authors combine gadolinium ions with amorphous calcium carbonate to make stable paramagnetic amorphous carbonate nanoclusters with high MRI contrast and significantly improved biocompatibility over commercial gadolinium-based agents.https://doi.org/10.1038/s41467-022-32615-3 |
spellingShingle | Liang Dong Yun-Jun Xu Cong Sui Yang Zhao Li-Bo Mao Denis Gebauer Rose Rosenberg Jonathan Avaro Ya-Dong Wu Huai-Ling Gao Zhao Pan Hui-Qin Wen Xu Yan Fei Li Yang Lu Helmut Cölfen Shu-Hong Yu Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent Nature Communications |
title | Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent |
title_full | Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent |
title_fullStr | Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent |
title_full_unstemmed | Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent |
title_short | Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent |
title_sort | highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an mri contrast agent |
url | https://doi.org/10.1038/s41467-022-32615-3 |
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