Ginseng-plus-Bai-Hu-Tang ameliorates diet-induced obesity, hepatic steatosis, and insulin resistance in mice
Background: Dietary fat has been suggested to be the cause of various health issues. Obesity, hypertension, cardiovascular disease, diabetes, dyslipidemia, and kidney disease are known to be associated with a high-fat diet (HFD). Obesity and associated conditions, such as type 2 diabetes mellitus an...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-03-01
|
| Series: | Journal of Ginseng Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1226845318301283 |
| _version_ | 1818016557564952576 |
|---|---|
| author | Hsu-Feng Lu Yu-Heng Lai Hsiu-Chen Huang I-Jung Lee Lie-Chwen Lin Hui-Kang Liu Hsiao-Hsuan Tien Cheng Huang |
| author_facet | Hsu-Feng Lu Yu-Heng Lai Hsiu-Chen Huang I-Jung Lee Lie-Chwen Lin Hui-Kang Liu Hsiao-Hsuan Tien Cheng Huang |
| author_sort | Hsu-Feng Lu |
| collection | DOAJ |
| description | Background: Dietary fat has been suggested to be the cause of various health issues. Obesity, hypertension, cardiovascular disease, diabetes, dyslipidemia, and kidney disease are known to be associated with a high-fat diet (HFD). Obesity and associated conditions, such as type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD), are currently a worldwide health problem. Few prospective pharmaceutical therapies that directly target NAFLD are available at present. A Traditional Chinese Medicine, ginseng-plus-Bai-Hu-Tang (GBHT), is widely used by diabetic patients to control glucose level or thirst. However, whether it has therapeutic effects on fat-induced hepatic steatosis and metabolic syndrome remains unclear. Methods: This study was conducted to examine the therapeutic effect of GBHT on fat-induced obesity, hepatic steatosis, and insulin resistance in mice. Results: GBHT protected mice against HFD-induced body weight gain, hyperlipidemia, and hyperglycemia compared with mice that were not treated. GBHT inhibited the expansion of adipose tissue and adipocyte hypertrophy. No ectopic fat deposition was found in the livers of HFD mice treated with GBHT. In addition, glucose intolerance and insulin sensitivity in HFD mice was also improved by GBHT. Conclusion: GBHT prevents changes in lipid and carbohydrate metabolism in a HFD mouse model. Our findings provide evidence for the traditional use of GBHT as therapy for the management of metabolic syndrome. Keywords: diet-induced obesity, ginseng-plus-Bai-Hu-Tang, hepatic steatosis, insulin resistance, Panax ginseng |
| first_indexed | 2024-04-14T07:13:59Z |
| format | Article |
| id | doaj.art-c58f4d9add5446f1af9ff3ae65b7588d |
| institution | Directory Open Access Journal |
| issn | 1226-8453 |
| language | English |
| last_indexed | 2024-04-14T07:13:59Z |
| publishDate | 2020-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Ginseng Research |
| spelling | doaj.art-c58f4d9add5446f1af9ff3ae65b7588d2022-12-22T02:06:21ZengElsevierJournal of Ginseng Research1226-84532020-03-01442238246Ginseng-plus-Bai-Hu-Tang ameliorates diet-induced obesity, hepatic steatosis, and insulin resistance in miceHsu-Feng Lu0Yu-Heng Lai1Hsiu-Chen Huang2I-Jung Lee3Lie-Chwen Lin4Hui-Kang Liu5Hsiao-Hsuan Tien6Cheng Huang7Departments of Clinical Pathology, Cheng Hsin General Hospital, Taipei, Taiwan; Department of Restaurant, Hotel and Institutional Management, Fu-Jen Catholic University, New Taipei, TaiwanDepartment of Chemistry, Chinese Culture University, Taipei, TaiwanDepartment of Applied Science, National Tsing Hua University South Campus, Hsinchu, TaiwanDepartment of Kampo Medicine, Yokohama University of Pharmacy, Kanagawa, JapanNational Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, TaiwanNational Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, Taiwan; Ph.D. Program in Clinical Drug Development of Chinese Herbal Medicine, Taipei Medical University, Taipei, TaiwanDepartment of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, TaiwanDepartment of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Earth and Life Sciences, University of Taipei, Taipei, Taiwan; Corresponding author. Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong St., Beitou District, Taipei 11221, Taiwan.Background: Dietary fat has been suggested to be the cause of various health issues. Obesity, hypertension, cardiovascular disease, diabetes, dyslipidemia, and kidney disease are known to be associated with a high-fat diet (HFD). Obesity and associated conditions, such as type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD), are currently a worldwide health problem. Few prospective pharmaceutical therapies that directly target NAFLD are available at present. A Traditional Chinese Medicine, ginseng-plus-Bai-Hu-Tang (GBHT), is widely used by diabetic patients to control glucose level or thirst. However, whether it has therapeutic effects on fat-induced hepatic steatosis and metabolic syndrome remains unclear. Methods: This study was conducted to examine the therapeutic effect of GBHT on fat-induced obesity, hepatic steatosis, and insulin resistance in mice. Results: GBHT protected mice against HFD-induced body weight gain, hyperlipidemia, and hyperglycemia compared with mice that were not treated. GBHT inhibited the expansion of adipose tissue and adipocyte hypertrophy. No ectopic fat deposition was found in the livers of HFD mice treated with GBHT. In addition, glucose intolerance and insulin sensitivity in HFD mice was also improved by GBHT. Conclusion: GBHT prevents changes in lipid and carbohydrate metabolism in a HFD mouse model. Our findings provide evidence for the traditional use of GBHT as therapy for the management of metabolic syndrome. Keywords: diet-induced obesity, ginseng-plus-Bai-Hu-Tang, hepatic steatosis, insulin resistance, Panax ginsenghttp://www.sciencedirect.com/science/article/pii/S1226845318301283 |
| spellingShingle | Hsu-Feng Lu Yu-Heng Lai Hsiu-Chen Huang I-Jung Lee Lie-Chwen Lin Hui-Kang Liu Hsiao-Hsuan Tien Cheng Huang Ginseng-plus-Bai-Hu-Tang ameliorates diet-induced obesity, hepatic steatosis, and insulin resistance in mice Journal of Ginseng Research |
| title | Ginseng-plus-Bai-Hu-Tang ameliorates diet-induced obesity, hepatic steatosis, and insulin resistance in mice |
| title_full | Ginseng-plus-Bai-Hu-Tang ameliorates diet-induced obesity, hepatic steatosis, and insulin resistance in mice |
| title_fullStr | Ginseng-plus-Bai-Hu-Tang ameliorates diet-induced obesity, hepatic steatosis, and insulin resistance in mice |
| title_full_unstemmed | Ginseng-plus-Bai-Hu-Tang ameliorates diet-induced obesity, hepatic steatosis, and insulin resistance in mice |
| title_short | Ginseng-plus-Bai-Hu-Tang ameliorates diet-induced obesity, hepatic steatosis, and insulin resistance in mice |
| title_sort | ginseng plus bai hu tang ameliorates diet induced obesity hepatic steatosis and insulin resistance in mice |
| url | http://www.sciencedirect.com/science/article/pii/S1226845318301283 |
| work_keys_str_mv | AT hsufenglu ginsengplusbaihutangamelioratesdietinducedobesityhepaticsteatosisandinsulinresistanceinmice AT yuhenglai ginsengplusbaihutangamelioratesdietinducedobesityhepaticsteatosisandinsulinresistanceinmice AT hsiuchenhuang ginsengplusbaihutangamelioratesdietinducedobesityhepaticsteatosisandinsulinresistanceinmice AT ijunglee ginsengplusbaihutangamelioratesdietinducedobesityhepaticsteatosisandinsulinresistanceinmice AT liechwenlin ginsengplusbaihutangamelioratesdietinducedobesityhepaticsteatosisandinsulinresistanceinmice AT huikangliu ginsengplusbaihutangamelioratesdietinducedobesityhepaticsteatosisandinsulinresistanceinmice AT hsiaohsuantien ginsengplusbaihutangamelioratesdietinducedobesityhepaticsteatosisandinsulinresistanceinmice AT chenghuang ginsengplusbaihutangamelioratesdietinducedobesityhepaticsteatosisandinsulinresistanceinmice |