Lipid Profile and Inflammation in Degenerative Valvular Disease
Aim: Degenerative valvular heart disease (DVHD) may cause serious cardiac problems and mortality. Determination of the factors related to DVHD may render possible the prevention and/or slowing down the progression of DVHD. In this study, we evaluated the relationship of DVHD with lipid profile,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2015-03-01
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| Series: | Haseki Tıp Bülteni |
| Subjects: | |
| Online Access: | http://www.hasekidergisi.com/article_8701/Lipid-Profile-And-Inflammation-In-Degenerative-Valvular-Disease |
| Summary: | Aim: Degenerative valvular heart disease (DVHD) may cause
serious cardiac problems and mortality. Determination of the
factors related to DVHD may render possible the prevention and/or
slowing down the progression of DVHD. In this study, we evaluated
the relationship of DVHD with lipid profile, microalbuminuria and
high sensitive C-reactive protein (hsCRP) levels.
Methods: 50 patients (age=65.6±12.4 years) with DVHD
were compared with the control group including 20 patients
(age=57.3±13.9 years) with left ventricle hypertrophy, but no
DVHD. Microalbuminuria, blood lipid parameters and hsCRP
levels were measured besides routine biochemical tests. Clinical,
laboratory and echocardiographic findings were compared
between the groups.
Results: Total cholesterol, HDL-cholesterol and LDL-cholesterol
levels were significantly higher in DVHD group (215.26±48.59
mg/dL vs. 177.45±22.47 mg/dL, p=0.001; 45.04±11.03 mg/dL
vs. 38.90±11.82 mg/dL, p=0.043 and 138.49±40.69 mg/dL vs.
114.26±16.07 mg/dL, p=0.001) compared with control group.
hsCRP and microalbuminuria levels were relatively higher in DVHD
group.
Conclusion: Hyperlipidaemia is related to DHVD development,
and the progress of DHVD may be related to the inflammatory
process. Elevated hsCRP levels may be an indicator of pathologies
active in DVHD development. Routine echocardiographic analysis
in hypertensive patients with high hsCRP and LDL-cholesterol
levels might be useful for screening of DVHD. (The Medical
Bulletin of Haseki 2015; 53: 62-6) |
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| ISSN: | 1302-0072 2147-2688 |