Protective effects of IRG1/itaconate on acute colitis through the inhibition of gasdermins-mediated pyroptosis and inflammation response

Protective effects of IRG1/itaconate on acute colitis through the inhibition of gasdermins-mediated pyroptosis and inflammation response

Inflammatory bowel disease (IBD) is a chronic relapsing gastrointestinal disorder, while the treatment effect is not satisfactory. Immune responsive gene 1 (IRG1) is a highly expressed gene in macrophage in response to inflammatory response and catalyzes the production of itaconate. Studies have rep...

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Bibliographic Details
Main Authors: Wenchang Yang, Yaxin Wang, Tao Wang, Chengguo Li, Liang Shi, Peng Zhang, Yuping Yin, Kaixiong Tao, Ruidong Li
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-07-01
Series:Genes and Diseases
Subjects:
Colitis
Gasdermin D
Gasdermin E
Inflammation
IRG1
Online Access:http://www.sciencedirect.com/science/article/pii/S235230422200174X

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