SHP-1 Regulates Antigen Cross-Presentation and Is Exploited by Leishmania to Evade Immunity

SHP-1 Regulates Antigen Cross-Presentation and Is Exploited by Leishmania to Evade Immunity

Summary: Intracellular pathogens have evolved strategies to evade detection by cytotoxic CD8+ T lymphocytes (CTLs). Here, we ask whether Leishmania parasites trigger the SHP-1-FcRγ chain inhibitory axis to dampen antigen cross-presentation in dendritic cells expressing the C-type lectin receptor Min...

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Bibliographic Details
Main Authors: Sofía C. Khouili, Emma C.L. Cook, Elena Hernández-García, María Martínez-López, Ruth Conde-Garrosa, Salvador Iborra
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Cell Reports
Subjects:
dendritic cells
antigen cross-presentation
Leishmania
Mincle
SHP-1
immune evasion
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720314571

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