Design of pH-responsive antimicrobial peptide melittin analog-camptothecin conjugates for tumor therapy
Melittin, a classical antimicrobial peptide, is a highly potent antitumor agent. However, its significant toxicity seriously hampers its application in tumor therapy. In this study, we developed novel melittin analogs with pH-responsive, cell-penetrating and membrane-lytic activities by replacing ar...
Main Authors: | Sujie Huang, Yuxuan Gao, Ling Ma, Bo Jia, Wenhao Zhao, Yufan Yao, Wenyuan Li, Tongyi Lin, Rui Wang, Jingjing Song, Wei Zhang |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2024-02-01
|
Series: | Asian Journal of Pharmaceutical Sciences |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087624000072 |
Similar Items
-
Antimicrobial and Cell-Penetrating Peptides: Understanding Penetration for the Design of Novel Conjugate Antibiotics
by: Andreas Hadjicharalambous, et al.
Published: (2022-11-01) -
New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets
by: Wioletta Brankiewicz, et al.
Published: (2022-03-01) -
Targeting the Melanocortin 1 Receptor in Melanoma: Biological Activity of α-MSH–Peptide Conjugates
by: Ildikó Szabó, et al.
Published: (2024-01-01) -
Comparing Variants of the Cell-Penetrating Peptide sC18 to Design Peptide-Drug Conjugates
by: Joshua Grabeck, et al.
Published: (2022-10-01) -
Molecular Dynamics Simulations of Drug-Conjugated Cell-Penetrating Peptides
by: Márton Ivánczi, et al.
Published: (2023-09-01)