DIPPER, a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics

DIPPER, a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics

The spatiotemporal proteome of the intervertebral disc (IVD) underpins its integrity and function. We present DIPPER, a deep and comprehensive IVD proteomic resource comprising 94 genome-wide profiles from 17 individuals. To begin with, protein modules defining key directional trends spanning the la...

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Bibliographic Details
Main Authors: Vivian Tam, Peikai Chen, Anita Yee, Nestor Solis, Theo Klein, Mateusz Kudelko, Rakesh Sharma, Wilson CW Chan, Christopher M Overall, Lisbet Haglund, Pak C Sham, Kathryn Song Eng Cheah, Danny Chan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
intervertebral disc
nucleus pulposus
proteomics
SILAC
degradome
ageing
Online Access:https://elifesciences.org/articles/64940

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