The venous thrombosis registry in Østfold Hospital (TROLL registry) ‐ design and cohort description
Abstract Purpose The incidence of venous thromboembolism (VTE) is expected to increase over the next decades, further increasing its substantial impact on patients and health care resources. Registries have the benefit of reporting real‐world data without excluding clinically important subgroups. Ou...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Research and Practice in Thrombosis and Haemostasis |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rth2.12770 |
| _version_ | 1797761064515928064 |
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| author | Camilla Tøvik Jørgensen Mazdak Tavoly Heidi Hassel Pettersen Eli Førsund Christina Roaldsnes Magnus Kringstad Olsen Eirik Tjønnfjord Jostein Gleditsch Aleksandra Grdinic Galovic Synne Frønæs Vikum Sigrid Kufaas Brækkan Waleed Ghanima |
| author_facet | Camilla Tøvik Jørgensen Mazdak Tavoly Heidi Hassel Pettersen Eli Førsund Christina Roaldsnes Magnus Kringstad Olsen Eirik Tjønnfjord Jostein Gleditsch Aleksandra Grdinic Galovic Synne Frønæs Vikum Sigrid Kufaas Brækkan Waleed Ghanima |
| author_sort | Camilla Tøvik Jørgensen |
| collection | DOAJ |
| description | Abstract Purpose The incidence of venous thromboembolism (VTE) is expected to increase over the next decades, further increasing its substantial impact on patients and health care resources. Registries have the benefit of reporting real‐world data without excluding clinically important subgroups. Our aim was to describe a Norwegian VTE registry and to provide descriptive data on the population and management. Registry Population The Venous Thrombosis Registry in Østfold Hospital (TROLL) is an ongoing registry of consecutive patients diagnosed with, treated, and/or followed up for VTE at Østfold Hospital, Norway, since 2005. Baseline and follow‐up data, including demographics, clinical features, risk factors, diagnostic procedures, classification of VTE, and treatment were collected during hospitalization, and at scheduled outpatient visits. Findings to Date From January 2005 to June 2021, 5037 patients were eligible for research in TROLL. Median age was 67 years (interquartile range, 55–77), and 2622 (52.1%) were male. Of these, 2736 (54.3%) had pulmonary embolism (PE), 2034 (40.4%) had deep vein thrombosis (DVT), and 265 (5.3%) had upper‐extremity DVT or splanchnic or cerebral sinus vein thrombosis. In total, 2330 (46.3%) were classified as unprovoked VTE, and 1131 (22.5%) had cancer. Direct oral anticoagulants were the most frequent therapeutic agents (39.3%) followed by low‐molecular‐weight heparins (30.4%) and vitamin K antagonists (30.3%). Outpatient treatment for PE increased from 4% in 2005 to 23% in 2019. Future Plans TROLL is a population‐based ongoing registry that represents a valuable source of real‐world data that will be used for future research on the management and outcomes of VTE. |
| first_indexed | 2024-03-12T19:07:34Z |
| format | Article |
| id | doaj.art-c596d421ebb64119b44ffdd06613a6f0 |
| institution | Directory Open Access Journal |
| issn | 2475-0379 |
| language | English |
| last_indexed | 2024-03-12T19:07:34Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Research and Practice in Thrombosis and Haemostasis |
| spelling | doaj.art-c596d421ebb64119b44ffdd06613a6f02023-08-02T06:07:37ZengElsevierResearch and Practice in Thrombosis and Haemostasis2475-03792022-07-0165n/an/a10.1002/rth2.12770The venous thrombosis registry in Østfold Hospital (TROLL registry) ‐ design and cohort descriptionCamilla Tøvik Jørgensen0Mazdak Tavoly1Heidi Hassel Pettersen2Eli Førsund3Christina Roaldsnes4Magnus Kringstad Olsen5Eirik Tjønnfjord6Jostein Gleditsch7Aleksandra Grdinic Galovic8Synne Frønæs Vikum9Sigrid Kufaas Brækkan10Waleed Ghanima11Department of Emergency Medicine Østfold Hospital Sarpsborg NorwayDepartment of Medicine Sahlgrenska University Hospital Gothenburg SwedenDepartment of Research Østfold Hospital Sarpsborg NorwayDepartment of Emergency Medicine Østfold Hospital Sarpsborg NorwayDepartment of Research Østfold Hospital Sarpsborg NorwayDepartment of Research Østfold Hospital Sarpsborg NorwayDepartment of Emergency Medicine Østfold Hospital Sarpsborg NorwayInstitute of Clinical Medicine University of Oslo Oslo NorwayDepartment of Cardiology Østfold Hospital Sarpsborg NorwayDepartment of Emergency Medicine Østfold Hospital Sarpsborg NorwayThrombosis Research Center (TREC), Department of Clinical Medicine, UiT The Arctic University of Norway Tromsø NorwayDepartment of Research Østfold Hospital Sarpsborg NorwayAbstract Purpose The incidence of venous thromboembolism (VTE) is expected to increase over the next decades, further increasing its substantial impact on patients and health care resources. Registries have the benefit of reporting real‐world data without excluding clinically important subgroups. Our aim was to describe a Norwegian VTE registry and to provide descriptive data on the population and management. Registry Population The Venous Thrombosis Registry in Østfold Hospital (TROLL) is an ongoing registry of consecutive patients diagnosed with, treated, and/or followed up for VTE at Østfold Hospital, Norway, since 2005. Baseline and follow‐up data, including demographics, clinical features, risk factors, diagnostic procedures, classification of VTE, and treatment were collected during hospitalization, and at scheduled outpatient visits. Findings to Date From January 2005 to June 2021, 5037 patients were eligible for research in TROLL. Median age was 67 years (interquartile range, 55–77), and 2622 (52.1%) were male. Of these, 2736 (54.3%) had pulmonary embolism (PE), 2034 (40.4%) had deep vein thrombosis (DVT), and 265 (5.3%) had upper‐extremity DVT or splanchnic or cerebral sinus vein thrombosis. In total, 2330 (46.3%) were classified as unprovoked VTE, and 1131 (22.5%) had cancer. Direct oral anticoagulants were the most frequent therapeutic agents (39.3%) followed by low‐molecular‐weight heparins (30.4%) and vitamin K antagonists (30.3%). Outpatient treatment for PE increased from 4% in 2005 to 23% in 2019. Future Plans TROLL is a population‐based ongoing registry that represents a valuable source of real‐world data that will be used for future research on the management and outcomes of VTE.https://doi.org/10.1002/rth2.12770anticoagulantscohortdeep vein thrombosispulmonary embolismregistryrisk factors |
| spellingShingle | Camilla Tøvik Jørgensen Mazdak Tavoly Heidi Hassel Pettersen Eli Førsund Christina Roaldsnes Magnus Kringstad Olsen Eirik Tjønnfjord Jostein Gleditsch Aleksandra Grdinic Galovic Synne Frønæs Vikum Sigrid Kufaas Brækkan Waleed Ghanima The venous thrombosis registry in Østfold Hospital (TROLL registry) ‐ design and cohort description Research and Practice in Thrombosis and Haemostasis anticoagulants cohort deep vein thrombosis pulmonary embolism registry risk factors |
| title | The venous thrombosis registry in Østfold Hospital (TROLL registry) ‐ design and cohort description |
| title_full | The venous thrombosis registry in Østfold Hospital (TROLL registry) ‐ design and cohort description |
| title_fullStr | The venous thrombosis registry in Østfold Hospital (TROLL registry) ‐ design and cohort description |
| title_full_unstemmed | The venous thrombosis registry in Østfold Hospital (TROLL registry) ‐ design and cohort description |
| title_short | The venous thrombosis registry in Østfold Hospital (TROLL registry) ‐ design and cohort description |
| title_sort | venous thrombosis registry in ostfold hospital troll registry design and cohort description |
| topic | anticoagulants cohort deep vein thrombosis pulmonary embolism registry risk factors |
| url | https://doi.org/10.1002/rth2.12770 |
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