Serum complement proteins rather than inflammatory factors is effective in predicting psychosis in individuals at clinical high risk
Abstract Immunological/inflammatory factors are implicated in the development of psychosis. Complement is a key driver of inflammation; however, it remains unknown which factor is better at predicting the onset of psychosis. This study aimed to compare the alteration and predictive performance of in...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-01-01
|
| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-022-02305-1 |
| _version_ | 1797952372482244608 |
|---|---|
| author | TianHong Zhang JiaHui Zeng JiaYi Ye YuQing Gao YeGang Hu LiHua Xu YanYan Wei XiaoChen Tang HaiChun Liu Tao Chen ChunBo Li ChunLing Wan JiJun Wang |
| author_facet | TianHong Zhang JiaHui Zeng JiaYi Ye YuQing Gao YeGang Hu LiHua Xu YanYan Wei XiaoChen Tang HaiChun Liu Tao Chen ChunBo Li ChunLing Wan JiJun Wang |
| author_sort | TianHong Zhang |
| collection | DOAJ |
| description | Abstract Immunological/inflammatory factors are implicated in the development of psychosis. Complement is a key driver of inflammation; however, it remains unknown which factor is better at predicting the onset of psychosis. This study aimed to compare the alteration and predictive performance of inflammation and complement in individuals at clinical high risk (CHR). We enrolled 49 individuals at CHR and 26 healthy controls (HCs). Twenty-five patients at CHR had converted to psychosis (converter) by the 3-year follow-up. Inflammatory cytokines, including interleukin (IL)-1β, 6, 8, 10, tumor necrosis factor-alpha (TNF-alpha), macrophage colony-stimulating factor levels, and complement proteins (C1q, C2, C3, C3b, C4, C4b, C5, C5a, factor B, D, I, H) were measured by enzyme-linked immunosorbent assay at baseline. Except for TNF- alpha, none of the inflammatory cytokines reached a significant level in either the comparison of CHR individuals and HC or between CHR-converters and non-converters. The C5, C3, D, I, and H levels were significantly lower (C5, p = 0.006; C3, p = 0.009; D, p = 0.026; I, p = 0.016; H, p = 0.019) in the CHR group than in the HC group. Compared to non-converters, converters had significantly lower levels of C5 (p = 0.012) and C5a (p = 0.007). None of the inflammatory factors, but many complement factors, showed significant correlations with changes in general function and symptoms. None of the inflammatory markers, except for C5a and C5, were significant in the discrimination of conversion outcomes in CHR individuals. Our results suggest that altered complement levels in the CHR population are more associated with conversion to psychosis than inflammatory factors. Therefore, an activated complement system may precede the first-episode of psychosis and contribute to neurological pathogenesis at the CHR stage. |
| first_indexed | 2024-04-10T22:45:18Z |
| format | Article |
| id | doaj.art-c597530c2f55405a96af277eb0675a80 |
| institution | Directory Open Access Journal |
| issn | 2158-3188 |
| language | English |
| last_indexed | 2024-04-10T22:45:18Z |
| publishDate | 2023-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj.art-c597530c2f55405a96af277eb0675a802023-01-15T12:22:07ZengNature Publishing GroupTranslational Psychiatry2158-31882023-01-011311910.1038/s41398-022-02305-1Serum complement proteins rather than inflammatory factors is effective in predicting psychosis in individuals at clinical high riskTianHong Zhang0JiaHui Zeng1JiaYi Ye2YuQing Gao3YeGang Hu4LiHua Xu5YanYan Wei6XiaoChen Tang7HaiChun Liu8Tao Chen9ChunBo Li10ChunLing Wan11JiJun Wang12Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic DisordersShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic DisordersShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic DisordersShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic DisordersShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic DisordersShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic DisordersShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic DisordersShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic DisordersDepartment of Automation, Shanghai Jiao Tong UniversityDepartment of Automation, Shanghai Jiao Tong UniversityShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic DisordersKey Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Bio-X Center, Shanghai Jiao Tong UniversityShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic DisordersAbstract Immunological/inflammatory factors are implicated in the development of psychosis. Complement is a key driver of inflammation; however, it remains unknown which factor is better at predicting the onset of psychosis. This study aimed to compare the alteration and predictive performance of inflammation and complement in individuals at clinical high risk (CHR). We enrolled 49 individuals at CHR and 26 healthy controls (HCs). Twenty-five patients at CHR had converted to psychosis (converter) by the 3-year follow-up. Inflammatory cytokines, including interleukin (IL)-1β, 6, 8, 10, tumor necrosis factor-alpha (TNF-alpha), macrophage colony-stimulating factor levels, and complement proteins (C1q, C2, C3, C3b, C4, C4b, C5, C5a, factor B, D, I, H) were measured by enzyme-linked immunosorbent assay at baseline. Except for TNF- alpha, none of the inflammatory cytokines reached a significant level in either the comparison of CHR individuals and HC or between CHR-converters and non-converters. The C5, C3, D, I, and H levels were significantly lower (C5, p = 0.006; C3, p = 0.009; D, p = 0.026; I, p = 0.016; H, p = 0.019) in the CHR group than in the HC group. Compared to non-converters, converters had significantly lower levels of C5 (p = 0.012) and C5a (p = 0.007). None of the inflammatory factors, but many complement factors, showed significant correlations with changes in general function and symptoms. None of the inflammatory markers, except for C5a and C5, were significant in the discrimination of conversion outcomes in CHR individuals. Our results suggest that altered complement levels in the CHR population are more associated with conversion to psychosis than inflammatory factors. Therefore, an activated complement system may precede the first-episode of psychosis and contribute to neurological pathogenesis at the CHR stage.https://doi.org/10.1038/s41398-022-02305-1 |
| spellingShingle | TianHong Zhang JiaHui Zeng JiaYi Ye YuQing Gao YeGang Hu LiHua Xu YanYan Wei XiaoChen Tang HaiChun Liu Tao Chen ChunBo Li ChunLing Wan JiJun Wang Serum complement proteins rather than inflammatory factors is effective in predicting psychosis in individuals at clinical high risk Translational Psychiatry |
| title | Serum complement proteins rather than inflammatory factors is effective in predicting psychosis in individuals at clinical high risk |
| title_full | Serum complement proteins rather than inflammatory factors is effective in predicting psychosis in individuals at clinical high risk |
| title_fullStr | Serum complement proteins rather than inflammatory factors is effective in predicting psychosis in individuals at clinical high risk |
| title_full_unstemmed | Serum complement proteins rather than inflammatory factors is effective in predicting psychosis in individuals at clinical high risk |
| title_short | Serum complement proteins rather than inflammatory factors is effective in predicting psychosis in individuals at clinical high risk |
| title_sort | serum complement proteins rather than inflammatory factors is effective in predicting psychosis in individuals at clinical high risk |
| url | https://doi.org/10.1038/s41398-022-02305-1 |
| work_keys_str_mv | AT tianhongzhang serumcomplementproteinsratherthaninflammatoryfactorsiseffectiveinpredictingpsychosisinindividualsatclinicalhighrisk AT jiahuizeng serumcomplementproteinsratherthaninflammatoryfactorsiseffectiveinpredictingpsychosisinindividualsatclinicalhighrisk AT jiayiye serumcomplementproteinsratherthaninflammatoryfactorsiseffectiveinpredictingpsychosisinindividualsatclinicalhighrisk AT yuqinggao serumcomplementproteinsratherthaninflammatoryfactorsiseffectiveinpredictingpsychosisinindividualsatclinicalhighrisk AT yeganghu serumcomplementproteinsratherthaninflammatoryfactorsiseffectiveinpredictingpsychosisinindividualsatclinicalhighrisk AT lihuaxu serumcomplementproteinsratherthaninflammatoryfactorsiseffectiveinpredictingpsychosisinindividualsatclinicalhighrisk AT yanyanwei serumcomplementproteinsratherthaninflammatoryfactorsiseffectiveinpredictingpsychosisinindividualsatclinicalhighrisk AT xiaochentang serumcomplementproteinsratherthaninflammatoryfactorsiseffectiveinpredictingpsychosisinindividualsatclinicalhighrisk AT haichunliu serumcomplementproteinsratherthaninflammatoryfactorsiseffectiveinpredictingpsychosisinindividualsatclinicalhighrisk AT taochen serumcomplementproteinsratherthaninflammatoryfactorsiseffectiveinpredictingpsychosisinindividualsatclinicalhighrisk AT chunboli serumcomplementproteinsratherthaninflammatoryfactorsiseffectiveinpredictingpsychosisinindividualsatclinicalhighrisk AT chunlingwan serumcomplementproteinsratherthaninflammatoryfactorsiseffectiveinpredictingpsychosisinindividualsatclinicalhighrisk AT jijunwang serumcomplementproteinsratherthaninflammatoryfactorsiseffectiveinpredictingpsychosisinindividualsatclinicalhighrisk |