Glycoursodeoxycholic acid regulates bile acids level and alters gut microbiota and glycolipid metabolism to attenuate diabetes
ABSTRACTAccumulating evidence suggests that the bile acid regulates type 2 diabetes mellitus (T2DM) through gut microbiota-host interactions. However, the mechanisms underlying such interactions have been unclear. Here, we found that glycoursodeoxycholic acid (GUDCA) positively regulates gut microbi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2023.2192155 |
| _version_ | 1797236678887211008 |
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| author | Bingting Chen Yu Bai Fenglian Tong Junlin Yan Rui Zhang Yewei Zhong Huiwen Tan Xiaoli Ma |
| author_facet | Bingting Chen Yu Bai Fenglian Tong Junlin Yan Rui Zhang Yewei Zhong Huiwen Tan Xiaoli Ma |
| author_sort | Bingting Chen |
| collection | DOAJ |
| description | ABSTRACTAccumulating evidence suggests that the bile acid regulates type 2 diabetes mellitus (T2DM) through gut microbiota-host interactions. However, the mechanisms underlying such interactions have been unclear. Here, we found that glycoursodeoxycholic acid (GUDCA) positively regulates gut microbiota by altering bile acid metabolism. GUDCA in mice resulted in higher taurolithocholic acid (TLCA) level and Bacteroides vulgatus abundance. Together, these changes resulted in the activation of the adipose G-protein-coupled bile acid receptor, GPBAR1 (TGR5) and upregulated expression of uncoupling protein UCP-1, resulting in elevation of white adipose tissue thermogenesis. The anti-T2DM effects of GUDCA are linked with the regulation of the bile acid and gut microbiota composition. This study suggests that altering bile acid metabolism, modifying the gut microbiota may be of value for the treatment of T2DM. |
| first_indexed | 2024-03-11T14:20:43Z |
| format | Article |
| id | doaj.art-c597797b65854d3d889f29d70c89f9d0 |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-04-24T17:07:41Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-c597797b65854d3d889f29d70c89f9d02024-03-28T22:38:19ZengTaylor & Francis GroupGut Microbes1949-09761949-09842023-12-0115110.1080/19490976.2023.2192155Glycoursodeoxycholic acid regulates bile acids level and alters gut microbiota and glycolipid metabolism to attenuate diabetesBingting Chen0Yu Bai1Fenglian Tong2Junlin Yan3Rui Zhang4Yewei Zhong5Huiwen Tan6Xiaoli Ma7College of Pharmacy, Xinjiang Medical University, Urumqi, ChinaThe Fourth Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaCollege of Pharmacy, Xinjiang Medical University, Urumqi, ChinaCollege of Pharmacy, Xinjiang Medical University, Urumqi, ChinaCollege of Pharmacy, Xinjiang Medical University, Urumqi, ChinaCollege of Pharmacy, Xinjiang Medical University, Urumqi, ChinaCollege of Pharmacy, Xinjiang Medical University, Urumqi, ChinaCollege of Pharmacy, Xinjiang Medical University, Urumqi, ChinaABSTRACTAccumulating evidence suggests that the bile acid regulates type 2 diabetes mellitus (T2DM) through gut microbiota-host interactions. However, the mechanisms underlying such interactions have been unclear. Here, we found that glycoursodeoxycholic acid (GUDCA) positively regulates gut microbiota by altering bile acid metabolism. GUDCA in mice resulted in higher taurolithocholic acid (TLCA) level and Bacteroides vulgatus abundance. Together, these changes resulted in the activation of the adipose G-protein-coupled bile acid receptor, GPBAR1 (TGR5) and upregulated expression of uncoupling protein UCP-1, resulting in elevation of white adipose tissue thermogenesis. The anti-T2DM effects of GUDCA are linked with the regulation of the bile acid and gut microbiota composition. This study suggests that altering bile acid metabolism, modifying the gut microbiota may be of value for the treatment of T2DM.https://www.tandfonline.com/doi/10.1080/19490976.2023.2192155Type 2 diabetesbile acidsgut microbiotaglycoursodeoxycholic acid |
| spellingShingle | Bingting Chen Yu Bai Fenglian Tong Junlin Yan Rui Zhang Yewei Zhong Huiwen Tan Xiaoli Ma Glycoursodeoxycholic acid regulates bile acids level and alters gut microbiota and glycolipid metabolism to attenuate diabetes Gut Microbes Type 2 diabetes bile acids gut microbiota glycoursodeoxycholic acid |
| title | Glycoursodeoxycholic acid regulates bile acids level and alters gut microbiota and glycolipid metabolism to attenuate diabetes |
| title_full | Glycoursodeoxycholic acid regulates bile acids level and alters gut microbiota and glycolipid metabolism to attenuate diabetes |
| title_fullStr | Glycoursodeoxycholic acid regulates bile acids level and alters gut microbiota and glycolipid metabolism to attenuate diabetes |
| title_full_unstemmed | Glycoursodeoxycholic acid regulates bile acids level and alters gut microbiota and glycolipid metabolism to attenuate diabetes |
| title_short | Glycoursodeoxycholic acid regulates bile acids level and alters gut microbiota and glycolipid metabolism to attenuate diabetes |
| title_sort | glycoursodeoxycholic acid regulates bile acids level and alters gut microbiota and glycolipid metabolism to attenuate diabetes |
| topic | Type 2 diabetes bile acids gut microbiota glycoursodeoxycholic acid |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2023.2192155 |
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