Salmonella Pathogenicity Island 1 (SPI-1) and Its Complex Regulatory Network
Salmonella species can infect a diverse range of birds, reptiles, and mammals, including humans. The type III protein secretion system (T3SS) encoded by Salmonella pathogenicity island 1 (SPI-1) delivers effector proteins required for intestinal invasion and the production of enteritis. The T3SS is...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcimb.2019.00270/full |
| _version_ | 1818849894343901184 |
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| author | Lixin Lou Peng Zhang Peng Zhang Rongli Piao Rongli Piao Yang Wang Yang Wang |
| author_facet | Lixin Lou Peng Zhang Peng Zhang Rongli Piao Rongli Piao Yang Wang Yang Wang |
| author_sort | Lixin Lou |
| collection | DOAJ |
| description | Salmonella species can infect a diverse range of birds, reptiles, and mammals, including humans. The type III protein secretion system (T3SS) encoded by Salmonella pathogenicity island 1 (SPI-1) delivers effector proteins required for intestinal invasion and the production of enteritis. The T3SS is regarded as the most important virulence factor of Salmonella. SPI-1 encodes transcription factors that regulate the expression of some virulence factors of Salmonella, while other transcription factors encoded outside SPI-1 participate in the expression of SPI-1-encoded genes. SPI-1 genes are responsible for the invasion of host cells, regulation of the host immune response, e.g., the host inflammatory response, immune cell recruitment and apoptosis, and biofilm formation. The regulatory network of SPI-1 is very complex and crucial. Here, we review the function, effectors, and regulation of SPI-1 genes and their contribution to the pathogenicity of Salmonella. |
| first_indexed | 2024-12-19T06:40:29Z |
| format | Article |
| id | doaj.art-c597c3ed730f436e81c3c1b17a98933a |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-19T06:40:29Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-c597c3ed730f436e81c3c1b17a98933a2022-12-21T20:32:06ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882019-07-01910.3389/fcimb.2019.00270463380Salmonella Pathogenicity Island 1 (SPI-1) and Its Complex Regulatory NetworkLixin Lou0Peng Zhang1Peng Zhang2Rongli Piao3Rongli Piao4Yang Wang5Yang Wang6Department of Infectious Diseases, First Hospital of Jilin University, Changchun, ChinaDepartment of Infectious Diseases, First Hospital of Jilin University, Changchun, ChinaDepartment of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United StatesDepartment of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United StatesDepartment of Gastroenterology, First Hospital of Jilin University, Changchun, ChinaDepartment of Infectious Diseases, First Hospital of Jilin University, Changchun, ChinaDepartment of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United StatesSalmonella species can infect a diverse range of birds, reptiles, and mammals, including humans. The type III protein secretion system (T3SS) encoded by Salmonella pathogenicity island 1 (SPI-1) delivers effector proteins required for intestinal invasion and the production of enteritis. The T3SS is regarded as the most important virulence factor of Salmonella. SPI-1 encodes transcription factors that regulate the expression of some virulence factors of Salmonella, while other transcription factors encoded outside SPI-1 participate in the expression of SPI-1-encoded genes. SPI-1 genes are responsible for the invasion of host cells, regulation of the host immune response, e.g., the host inflammatory response, immune cell recruitment and apoptosis, and biofilm formation. The regulatory network of SPI-1 is very complex and crucial. Here, we review the function, effectors, and regulation of SPI-1 genes and their contribution to the pathogenicity of Salmonella.https://www.frontiersin.org/article/10.3389/fcimb.2019.00270/fullSalmonellaSPI-1T3SSeffectorregulationimmune response |
| spellingShingle | Lixin Lou Peng Zhang Peng Zhang Rongli Piao Rongli Piao Yang Wang Yang Wang Salmonella Pathogenicity Island 1 (SPI-1) and Its Complex Regulatory Network Frontiers in Cellular and Infection Microbiology Salmonella SPI-1 T3SS effector regulation immune response |
| title | Salmonella Pathogenicity Island 1 (SPI-1) and Its Complex Regulatory Network |
| title_full | Salmonella Pathogenicity Island 1 (SPI-1) and Its Complex Regulatory Network |
| title_fullStr | Salmonella Pathogenicity Island 1 (SPI-1) and Its Complex Regulatory Network |
| title_full_unstemmed | Salmonella Pathogenicity Island 1 (SPI-1) and Its Complex Regulatory Network |
| title_short | Salmonella Pathogenicity Island 1 (SPI-1) and Its Complex Regulatory Network |
| title_sort | salmonella pathogenicity island 1 spi 1 and its complex regulatory network |
| topic | Salmonella SPI-1 T3SS effector regulation immune response |
| url | https://www.frontiersin.org/article/10.3389/fcimb.2019.00270/full |
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