Deficits in Acoustic Startle Reactivity and Auditory Temporal Processing after Traumatic Brain Injury
Traumatic brain injury (TBI) exacts significant neurological and financial costs on patients and their families. In adult patients with moderate-to-severe TBI, central auditory impairments have been reported. These auditory impairments may interfere with language receptivity, as observed in children...
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| Format: | Article |
| Language: | English |
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Mary Ann Liebert
2022-05-01
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| Series: | Neurotrauma Reports |
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| Online Access: | https://www.liebertpub.com/doi/full/10.1089/NEUR.2021.0077 |
| _version_ | 1797346190888534016 |
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| author | Steven W. Threlkeld Emma Morales Cestero John Marshall Joanna Szmydynger-Chodobska Adam Chodobski |
| author_facet | Steven W. Threlkeld Emma Morales Cestero John Marshall Joanna Szmydynger-Chodobska Adam Chodobski |
| author_sort | Steven W. Threlkeld |
| collection | DOAJ |
| description | Traumatic brain injury (TBI) exacts significant neurological and financial costs on patients and their families. In adult patients with moderate-to-severe TBI, central auditory impairments have been reported. These auditory impairments may interfere with language receptivity, as observed in children with developmental brain injury. Although rodent models of TBI have been widely used to examine behavioral outcomes, few studies have evaluated how TBI affects higher-order central auditory processing across a range of cue complexities. Here, auditory processing was assessed using a modified acoustic startle paradigm. We used a battery of progressively complex stimuli (single-tone, silent gaps in white noise, and frequency-modulated [FM] sweeps) in adult rats that received unilateral controlled cortical impact injury. TBI subjects showed significant reductions in acoustic startle absolute responses across nearly all stimuli, regardless of cue, duration of stimuli, or cue complexity. Despite this overall reduction of startle magnitudes in injured animals, the detection of single-tone stimuli was comparable between TBI and sham-injured subjects, indicating intact hearing after TBI. TBI subjects showed deficits in rapid gap (5?ms) and FM sweep (175?ms) detection, and, in contrast to shams, they did not improve on detecting silent gaps and FM sweeps across days of testing. Our findings provide evidence for both low-level (brainstem-mediated) and higher-order central auditory processing deficits in a rodent model of TBI, which parallel sensory impairments observed in TBI patients. The present findings support the use of modified pre-pule auditory detection paradigms to investigate clinically relevant processes in TBI. |
| first_indexed | 2024-03-08T11:29:25Z |
| format | Article |
| id | doaj.art-c59954c170684b86bf689b2137525f41 |
| institution | Directory Open Access Journal |
| issn | 2689-288X |
| language | English |
| last_indexed | 2024-03-08T11:29:25Z |
| publishDate | 2022-05-01 |
| publisher | Mary Ann Liebert |
| record_format | Article |
| series | Neurotrauma Reports |
| spelling | doaj.art-c59954c170684b86bf689b2137525f412024-01-26T04:33:45ZengMary Ann LiebertNeurotrauma Reports2689-288X2022-05-013120721610.1089/NEUR.2021.0077Deficits in Acoustic Startle Reactivity and Auditory Temporal Processing after Traumatic Brain InjurySteven W. ThrelkeldEmma Morales CesteroJohn MarshallJoanna Szmydynger-ChodobskaAdam ChodobskiTraumatic brain injury (TBI) exacts significant neurological and financial costs on patients and their families. In adult patients with moderate-to-severe TBI, central auditory impairments have been reported. These auditory impairments may interfere with language receptivity, as observed in children with developmental brain injury. Although rodent models of TBI have been widely used to examine behavioral outcomes, few studies have evaluated how TBI affects higher-order central auditory processing across a range of cue complexities. Here, auditory processing was assessed using a modified acoustic startle paradigm. We used a battery of progressively complex stimuli (single-tone, silent gaps in white noise, and frequency-modulated [FM] sweeps) in adult rats that received unilateral controlled cortical impact injury. TBI subjects showed significant reductions in acoustic startle absolute responses across nearly all stimuli, regardless of cue, duration of stimuli, or cue complexity. Despite this overall reduction of startle magnitudes in injured animals, the detection of single-tone stimuli was comparable between TBI and sham-injured subjects, indicating intact hearing after TBI. TBI subjects showed deficits in rapid gap (5?ms) and FM sweep (175?ms) detection, and, in contrast to shams, they did not improve on detecting silent gaps and FM sweeps across days of testing. Our findings provide evidence for both low-level (brainstem-mediated) and higher-order central auditory processing deficits in a rodent model of TBI, which parallel sensory impairments observed in TBI patients. The present findings support the use of modified pre-pule auditory detection paradigms to investigate clinically relevant processes in TBI.https://www.liebertpub.com/doi/full/10.1089/NEUR.2021.0077central auditory processing deficitsmodified acoustic startletraumatic brain injury |
| spellingShingle | Steven W. Threlkeld Emma Morales Cestero John Marshall Joanna Szmydynger-Chodobska Adam Chodobski Deficits in Acoustic Startle Reactivity and Auditory Temporal Processing after Traumatic Brain Injury Neurotrauma Reports central auditory processing deficits modified acoustic startle traumatic brain injury |
| title | Deficits in Acoustic Startle Reactivity and Auditory Temporal Processing after Traumatic Brain Injury |
| title_full | Deficits in Acoustic Startle Reactivity and Auditory Temporal Processing after Traumatic Brain Injury |
| title_fullStr | Deficits in Acoustic Startle Reactivity and Auditory Temporal Processing after Traumatic Brain Injury |
| title_full_unstemmed | Deficits in Acoustic Startle Reactivity and Auditory Temporal Processing after Traumatic Brain Injury |
| title_short | Deficits in Acoustic Startle Reactivity and Auditory Temporal Processing after Traumatic Brain Injury |
| title_sort | deficits in acoustic startle reactivity and auditory temporal processing after traumatic brain injury |
| topic | central auditory processing deficits modified acoustic startle traumatic brain injury |
| url | https://www.liebertpub.com/doi/full/10.1089/NEUR.2021.0077 |
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