Characterisation of the Upper Respiratory Tract Virome of Feedlot Cattle and Its Association with Bovine Respiratory Disease
Bovine respiratory disease (BRD) is a major health problem within the global cattle industry. This disease has a complex aetiology, with viruses playing an integral role. In this study, metagenomics was used to sequence viral nucleic acids in the nasal swabs of BRD-affected cattle. The viruses detec...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/2/455 |
| _version_ | 1797617809907253248 |
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| author | Rebecca K. Ambrose Claudia Blakebrough-Hall Jennifer L. Gravel Luciano A. Gonzalez Timothy J. Mahony |
| author_facet | Rebecca K. Ambrose Claudia Blakebrough-Hall Jennifer L. Gravel Luciano A. Gonzalez Timothy J. Mahony |
| author_sort | Rebecca K. Ambrose |
| collection | DOAJ |
| description | Bovine respiratory disease (BRD) is a major health problem within the global cattle industry. This disease has a complex aetiology, with viruses playing an integral role. In this study, metagenomics was used to sequence viral nucleic acids in the nasal swabs of BRD-affected cattle. The viruses detected included those that are well known for their association with BRD in Australia (bovine viral diarrhoea virus 1), as well as viruses known to be present but not fully characterised (bovine coronavirus) and viruses that have not been reported in BRD-affected cattle in Australia (bovine rhinitis, bovine influenza D, and bovine nidovirus). The nasal swabs from a case–control study were subsequently tested for 10 viruses, and the presence of at least one virus was found to be significantly associated with BRD. Some of the more recently detected viruses had inconsistent associations with BRD. Full genome sequences for bovine coronavirus, a virus increasingly associated with BRD, and bovine nidovirus were completed. Both viruses belong to the <i>Coronaviridae</i> family, which are frequently associated with disease in mammals. This study has provided greater insights into the viral pathogens associated with BRD and highlighted the need for further studies to more precisely elucidate the roles viruses play in BRD. |
| first_indexed | 2024-03-11T08:01:04Z |
| format | Article |
| id | doaj.art-c599bc3daa1145c78ad5e4ef6247b00e |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T08:01:04Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-c599bc3daa1145c78ad5e4ef6247b00e2023-11-16T23:49:14ZengMDPI AGViruses1999-49152023-02-0115245510.3390/v15020455Characterisation of the Upper Respiratory Tract Virome of Feedlot Cattle and Its Association with Bovine Respiratory DiseaseRebecca K. Ambrose0Claudia Blakebrough-Hall1Jennifer L. Gravel2Luciano A. Gonzalez3Timothy J. Mahony4Agriscience Queensland, Department of Agriculture and Fisheries, Ecosciences Precinct, Dutton Park, Brisbane, QLD 4102, AustraliaSchool of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, NSW 2570, AustraliaAgriscience Queensland, Department of Agriculture and Fisheries, Ecosciences Precinct, Dutton Park, Brisbane, QLD 4102, AustraliaSchool of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, NSW 2570, AustraliaQueensland Alliance for Agriculture and Food Innovation, Queensland Bioscieces Precinct, The University of Queensland, Brisbane, QLD 4072, AustraliaBovine respiratory disease (BRD) is a major health problem within the global cattle industry. This disease has a complex aetiology, with viruses playing an integral role. In this study, metagenomics was used to sequence viral nucleic acids in the nasal swabs of BRD-affected cattle. The viruses detected included those that are well known for their association with BRD in Australia (bovine viral diarrhoea virus 1), as well as viruses known to be present but not fully characterised (bovine coronavirus) and viruses that have not been reported in BRD-affected cattle in Australia (bovine rhinitis, bovine influenza D, and bovine nidovirus). The nasal swabs from a case–control study were subsequently tested for 10 viruses, and the presence of at least one virus was found to be significantly associated with BRD. Some of the more recently detected viruses had inconsistent associations with BRD. Full genome sequences for bovine coronavirus, a virus increasingly associated with BRD, and bovine nidovirus were completed. Both viruses belong to the <i>Coronaviridae</i> family, which are frequently associated with disease in mammals. This study has provided greater insights into the viral pathogens associated with BRD and highlighted the need for further studies to more precisely elucidate the roles viruses play in BRD.https://www.mdpi.com/1999-4915/15/2/455bovine respiratory diseaseviromebovine nidovirusbovine coronavirusbovine herpesvirus 1bovine viral diarrhoea virus 1 |
| spellingShingle | Rebecca K. Ambrose Claudia Blakebrough-Hall Jennifer L. Gravel Luciano A. Gonzalez Timothy J. Mahony Characterisation of the Upper Respiratory Tract Virome of Feedlot Cattle and Its Association with Bovine Respiratory Disease Viruses bovine respiratory disease virome bovine nidovirus bovine coronavirus bovine herpesvirus 1 bovine viral diarrhoea virus 1 |
| title | Characterisation of the Upper Respiratory Tract Virome of Feedlot Cattle and Its Association with Bovine Respiratory Disease |
| title_full | Characterisation of the Upper Respiratory Tract Virome of Feedlot Cattle and Its Association with Bovine Respiratory Disease |
| title_fullStr | Characterisation of the Upper Respiratory Tract Virome of Feedlot Cattle and Its Association with Bovine Respiratory Disease |
| title_full_unstemmed | Characterisation of the Upper Respiratory Tract Virome of Feedlot Cattle and Its Association with Bovine Respiratory Disease |
| title_short | Characterisation of the Upper Respiratory Tract Virome of Feedlot Cattle and Its Association with Bovine Respiratory Disease |
| title_sort | characterisation of the upper respiratory tract virome of feedlot cattle and its association with bovine respiratory disease |
| topic | bovine respiratory disease virome bovine nidovirus bovine coronavirus bovine herpesvirus 1 bovine viral diarrhoea virus 1 |
| url | https://www.mdpi.com/1999-4915/15/2/455 |
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