Cognitive impairment following traumatic brain injury in Uganda: Prevalence and associated factors
<h4>Background</h4> As the burden of dementia continues to rise in sub-Saharan Africa, it is crucial to develop an evidence base for potentially modifiable risk factors such as Traumatic Brain Injury (TBI). Cognitive impairment may result from TBI and since it is an established prodromal...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-01-01
|
| Series: | PLOS Global Public Health |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021383/?tool=EBI |
| _version_ | 1797694894604550144 |
|---|---|
| author | Timothy Mwanje Kintu Vanessa Katengeke Ronald Kamoga Tricia Nguyen Josephine Nambi Najjuma David Kitya Edith K. Wakida Celestino Obua Godfrey Zari Rukundo |
| author_facet | Timothy Mwanje Kintu Vanessa Katengeke Ronald Kamoga Tricia Nguyen Josephine Nambi Najjuma David Kitya Edith K. Wakida Celestino Obua Godfrey Zari Rukundo |
| author_sort | Timothy Mwanje Kintu |
| collection | DOAJ |
| description | <h4>Background</h4> As the burden of dementia continues to rise in sub-Saharan Africa, it is crucial to develop an evidence base for potentially modifiable risk factors such as Traumatic Brain Injury (TBI). Cognitive impairment may result from TBI and since it is an established prodromal form of dementia, we investigated the burden of cognitive impairment and associated factors in persons with a history of TBI in southwestern Uganda. <h4>Methods</h4> This was a community-based quantitative study with a cross-sectional design among 189 persons with a history of TBI in southwestern Uganda. Data were collected by the research team in March and June 2022 and entered into Kobo Toolbox before being transferred to RStudio version 4.1.0 for cleaning and analysis. Data were analyzed at a 5% level of significance. <h4>Results</h4> Most study participants had some form of cognitive impairment (56.1%), with 43.1% of the participants having mild cognitive impairment (MCI). Cognitive impairment was associated with older age (p-value<0.001); loss of consciousness following the TBI (p-value = 0.019) and a history of tobacco use (p-value = 0.003). As a measure of severity of the TBI, loss of consciousness (aOR = 4.09; CI = 1.57–11.76; p<0.01) and older age (aOR = 1.04; CI = 1.01–1.07; p<0.01) were identified as risk factors for cognitive impairment. <h4>Conclusion</h4> There is a high burden of cognitive impairment among individuals with a history of TBI in southwestern Uganda, and most associated risk factors are potentially modifiable. Long-term follow-up of TBI patients would enable early identification of some risks. Patients with TBI could benefit from behavioural modifications such as restriction of alcohol intake and tobacco use to slow down the progression into dementia. |
| first_indexed | 2024-03-12T03:04:28Z |
| format | Article |
| id | doaj.art-c59a071bae8e4864b332ff29792b0622 |
| institution | Directory Open Access Journal |
| issn | 2767-3375 |
| language | English |
| last_indexed | 2024-03-12T03:04:28Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLOS Global Public Health |
| spelling | doaj.art-c59a071bae8e4864b332ff29792b06222023-09-03T14:34:39ZengPublic Library of Science (PLoS)PLOS Global Public Health2767-33752023-01-0132Cognitive impairment following traumatic brain injury in Uganda: Prevalence and associated factorsTimothy Mwanje KintuVanessa KatengekeRonald KamogaTricia NguyenJosephine Nambi NajjumaDavid KityaEdith K. WakidaCelestino ObuaGodfrey Zari Rukundo<h4>Background</h4> As the burden of dementia continues to rise in sub-Saharan Africa, it is crucial to develop an evidence base for potentially modifiable risk factors such as Traumatic Brain Injury (TBI). Cognitive impairment may result from TBI and since it is an established prodromal form of dementia, we investigated the burden of cognitive impairment and associated factors in persons with a history of TBI in southwestern Uganda. <h4>Methods</h4> This was a community-based quantitative study with a cross-sectional design among 189 persons with a history of TBI in southwestern Uganda. Data were collected by the research team in March and June 2022 and entered into Kobo Toolbox before being transferred to RStudio version 4.1.0 for cleaning and analysis. Data were analyzed at a 5% level of significance. <h4>Results</h4> Most study participants had some form of cognitive impairment (56.1%), with 43.1% of the participants having mild cognitive impairment (MCI). Cognitive impairment was associated with older age (p-value<0.001); loss of consciousness following the TBI (p-value = 0.019) and a history of tobacco use (p-value = 0.003). As a measure of severity of the TBI, loss of consciousness (aOR = 4.09; CI = 1.57–11.76; p<0.01) and older age (aOR = 1.04; CI = 1.01–1.07; p<0.01) were identified as risk factors for cognitive impairment. <h4>Conclusion</h4> There is a high burden of cognitive impairment among individuals with a history of TBI in southwestern Uganda, and most associated risk factors are potentially modifiable. Long-term follow-up of TBI patients would enable early identification of some risks. Patients with TBI could benefit from behavioural modifications such as restriction of alcohol intake and tobacco use to slow down the progression into dementia.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021383/?tool=EBI |
| spellingShingle | Timothy Mwanje Kintu Vanessa Katengeke Ronald Kamoga Tricia Nguyen Josephine Nambi Najjuma David Kitya Edith K. Wakida Celestino Obua Godfrey Zari Rukundo Cognitive impairment following traumatic brain injury in Uganda: Prevalence and associated factors PLOS Global Public Health |
| title | Cognitive impairment following traumatic brain injury in Uganda: Prevalence and associated factors |
| title_full | Cognitive impairment following traumatic brain injury in Uganda: Prevalence and associated factors |
| title_fullStr | Cognitive impairment following traumatic brain injury in Uganda: Prevalence and associated factors |
| title_full_unstemmed | Cognitive impairment following traumatic brain injury in Uganda: Prevalence and associated factors |
| title_short | Cognitive impairment following traumatic brain injury in Uganda: Prevalence and associated factors |
| title_sort | cognitive impairment following traumatic brain injury in uganda prevalence and associated factors |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10021383/?tool=EBI |
| work_keys_str_mv | AT timothymwanjekintu cognitiveimpairmentfollowingtraumaticbraininjuryinugandaprevalenceandassociatedfactors AT vanessakatengeke cognitiveimpairmentfollowingtraumaticbraininjuryinugandaprevalenceandassociatedfactors AT ronaldkamoga cognitiveimpairmentfollowingtraumaticbraininjuryinugandaprevalenceandassociatedfactors AT tricianguyen cognitiveimpairmentfollowingtraumaticbraininjuryinugandaprevalenceandassociatedfactors AT josephinenambinajjuma cognitiveimpairmentfollowingtraumaticbraininjuryinugandaprevalenceandassociatedfactors AT davidkitya cognitiveimpairmentfollowingtraumaticbraininjuryinugandaprevalenceandassociatedfactors AT edithkwakida cognitiveimpairmentfollowingtraumaticbraininjuryinugandaprevalenceandassociatedfactors AT celestinoobua cognitiveimpairmentfollowingtraumaticbraininjuryinugandaprevalenceandassociatedfactors AT godfreyzarirukundo cognitiveimpairmentfollowingtraumaticbraininjuryinugandaprevalenceandassociatedfactors |