Evidence and consequences of the central role of the kidneys in the pathophysiology of sympathetic hyperactivity.
Chronic elevation of the sympathetic nervous system has been identified as a major contributor to the complex pathophysiology of hypertension, states of volume overload -such as heart failure- and progressive kidney disease. It is also a strong determinant for clinical outcome. This review focuses o...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012-02-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00029/full |
| _version_ | 1818984889323618304 |
|---|---|
| author | Eva Elisabeth Vink Peter J. Blankestijn |
| author_facet | Eva Elisabeth Vink Peter J. Blankestijn |
| author_sort | Eva Elisabeth Vink |
| collection | DOAJ |
| description | Chronic elevation of the sympathetic nervous system has been identified as a major contributor to the complex pathophysiology of hypertension, states of volume overload -such as heart failure- and progressive kidney disease. It is also a strong determinant for clinical outcome. This review focuses on the central role of the kidneys in the pathogenesis of sympathetic hyperactivity. As a consequence, renal denervation may be an attractive option to treat sympathetic hyperactivity. The review will also focus on first results and the still remaining questions of this new treatment option. |
| first_indexed | 2024-12-20T18:26:10Z |
| format | Article |
| id | doaj.art-c59ba462ae6d4f55a903ce41b0a02c5e |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-20T18:26:10Z |
| publishDate | 2012-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-c59ba462ae6d4f55a903ce41b0a02c5e2022-12-21T19:30:10ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2012-02-01310.3389/fphys.2012.0002918477Evidence and consequences of the central role of the kidneys in the pathophysiology of sympathetic hyperactivity.Eva Elisabeth Vink0Peter J. Blankestijn1University Medical Center UtrechtUniversity Medical Center UtrechtChronic elevation of the sympathetic nervous system has been identified as a major contributor to the complex pathophysiology of hypertension, states of volume overload -such as heart failure- and progressive kidney disease. It is also a strong determinant for clinical outcome. This review focuses on the central role of the kidneys in the pathogenesis of sympathetic hyperactivity. As a consequence, renal denervation may be an attractive option to treat sympathetic hyperactivity. The review will also focus on first results and the still remaining questions of this new treatment option.http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00029/fullHypertensionkidney diseaserenal denervationsympathetic activity |
| spellingShingle | Eva Elisabeth Vink Peter J. Blankestijn Evidence and consequences of the central role of the kidneys in the pathophysiology of sympathetic hyperactivity. Frontiers in Physiology Hypertension kidney disease renal denervation sympathetic activity |
| title | Evidence and consequences of the central role of the kidneys in the pathophysiology of sympathetic hyperactivity. |
| title_full | Evidence and consequences of the central role of the kidneys in the pathophysiology of sympathetic hyperactivity. |
| title_fullStr | Evidence and consequences of the central role of the kidneys in the pathophysiology of sympathetic hyperactivity. |
| title_full_unstemmed | Evidence and consequences of the central role of the kidneys in the pathophysiology of sympathetic hyperactivity. |
| title_short | Evidence and consequences of the central role of the kidneys in the pathophysiology of sympathetic hyperactivity. |
| title_sort | evidence and consequences of the central role of the kidneys in the pathophysiology of sympathetic hyperactivity |
| topic | Hypertension kidney disease renal denervation sympathetic activity |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00029/full |
| work_keys_str_mv | AT evaelisabethvink evidenceandconsequencesofthecentralroleofthekidneysinthepathophysiologyofsympathetichyperactivity AT peterjblankestijn evidenceandconsequencesofthecentralroleofthekidneysinthepathophysiologyofsympathetichyperactivity |