Sleep Related Epilepsy and Pharmacotherapy: An Insight
In the last several decades, sleep-related epilepsy has drawn considerable attention among epileptologists and neuroscientists in the interest of new paradigms of the disease etiology, pathogenesis and management. Sleep-related epilepsy is nocturnal seizures that manifest solely during the sleep sta...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2018.01088/full |
| _version_ | 1818111893242380288 |
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| author | Jaya Kumar Amro Solaiman Pasuk Mahakkanukrauh Pasuk Mahakkanukrauh Rashidi Mohamed Srijit Das |
| author_facet | Jaya Kumar Amro Solaiman Pasuk Mahakkanukrauh Pasuk Mahakkanukrauh Rashidi Mohamed Srijit Das |
| author_sort | Jaya Kumar |
| collection | DOAJ |
| description | In the last several decades, sleep-related epilepsy has drawn considerable attention among epileptologists and neuroscientists in the interest of new paradigms of the disease etiology, pathogenesis and management. Sleep-related epilepsy is nocturnal seizures that manifest solely during the sleep state. Sleep comprises two distinct stages i.e., non-rapid eye movement (NREM) and rapid eye movement (REM) that alternate every 90 min with NREM preceding REM. Current findings indicate that the sleep-related epilepsy manifests predominantly during the synchronized stages of sleep; NREM over REM stage. Sleep related hypermotor epilepsy (SHE), benign partial epilepsy with centrotemporal spikes or benign rolandic epilepsy (BECTS), and Panayiotopoulos Syndrome (PS) are three of the most frequently implicated epilepsies occurring during the sleep state. Although some familial types are described, others are seemingly sporadic occurrences. In the present review, we aim to discuss the predominance of sleep-related epilepsy during NREM, established familial links to the pathogenesis of SHE, BECTS and PS, and highlight the present available pharmacotherapy options. |
| first_indexed | 2024-12-11T03:10:16Z |
| format | Article |
| id | doaj.art-c59bf76d37274064a786fddb4a8001fc |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-11T03:10:16Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-c59bf76d37274064a786fddb4a8001fc2022-12-22T01:22:52ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-09-01910.3389/fphar.2018.01088386109Sleep Related Epilepsy and Pharmacotherapy: An InsightJaya Kumar0Amro Solaiman1Pasuk Mahakkanukrauh2Pasuk Mahakkanukrauh3Rashidi Mohamed4Srijit Das5Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MalaysiaDepartment of Anatomy, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MalaysiaDepartment of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandExcellence Centre in Forensic Osteology Research Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandDepartment of Familty Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MalaysiaDepartment of Anatomy, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MalaysiaIn the last several decades, sleep-related epilepsy has drawn considerable attention among epileptologists and neuroscientists in the interest of new paradigms of the disease etiology, pathogenesis and management. Sleep-related epilepsy is nocturnal seizures that manifest solely during the sleep state. Sleep comprises two distinct stages i.e., non-rapid eye movement (NREM) and rapid eye movement (REM) that alternate every 90 min with NREM preceding REM. Current findings indicate that the sleep-related epilepsy manifests predominantly during the synchronized stages of sleep; NREM over REM stage. Sleep related hypermotor epilepsy (SHE), benign partial epilepsy with centrotemporal spikes or benign rolandic epilepsy (BECTS), and Panayiotopoulos Syndrome (PS) are three of the most frequently implicated epilepsies occurring during the sleep state. Although some familial types are described, others are seemingly sporadic occurrences. In the present review, we aim to discuss the predominance of sleep-related epilepsy during NREM, established familial links to the pathogenesis of SHE, BECTS and PS, and highlight the present available pharmacotherapy options.https://www.frontiersin.org/article/10.3389/fphar.2018.01088/fullepilepsysleepseizureSHEBECTSPS |
| spellingShingle | Jaya Kumar Amro Solaiman Pasuk Mahakkanukrauh Pasuk Mahakkanukrauh Rashidi Mohamed Srijit Das Sleep Related Epilepsy and Pharmacotherapy: An Insight Frontiers in Pharmacology epilepsy sleep seizure SHE BECTS PS |
| title | Sleep Related Epilepsy and Pharmacotherapy: An Insight |
| title_full | Sleep Related Epilepsy and Pharmacotherapy: An Insight |
| title_fullStr | Sleep Related Epilepsy and Pharmacotherapy: An Insight |
| title_full_unstemmed | Sleep Related Epilepsy and Pharmacotherapy: An Insight |
| title_short | Sleep Related Epilepsy and Pharmacotherapy: An Insight |
| title_sort | sleep related epilepsy and pharmacotherapy an insight |
| topic | epilepsy sleep seizure SHE BECTS PS |
| url | https://www.frontiersin.org/article/10.3389/fphar.2018.01088/full |
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