Effects of Aqueous and Methanolic Extracts of Cichorium Intybus Seeds on Gentamicin Induced Nephrotoxicity in Rats
Objective: To evaluate the effects of Aqueous and Methanolic extracts of Cichorium Intybus seeds on Gentamicin induced nephrotoxicity in rats. Study Design: Experimental Study Place and Duration of Study: Study was conducted from 15 January to 31 March 2017 at National Institute of Health Sciences (...
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| Format: | Article |
| Language: | English |
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Riphah International University, Islamabad
2018-12-01
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| Series: | Journal of Islamic International Medical College |
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| Online Access: | https://journals.riphah.edu.pk/index.php/jiimc/article/view/1054 |
| _version_ | 1798030886869925888 |
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| author | Muhammad Tahir , Noman Sadiq , Sameer Ahmed , Amanat Ali , Noor Nasir Rajpoot , Uzma Riaz |
| author_facet | Muhammad Tahir , Noman Sadiq , Sameer Ahmed , Amanat Ali , Noor Nasir Rajpoot , Uzma Riaz |
| author_sort | Muhammad Tahir , Noman Sadiq , Sameer Ahmed , Amanat Ali , Noor Nasir Rajpoot , Uzma Riaz |
| collection | DOAJ |
| description | Objective: To evaluate the effects of Aqueous and Methanolic extracts of Cichorium Intybus seeds on Gentamicin induced nephrotoxicity in rats.
Study Design: Experimental Study
Place and Duration of Study: Study was conducted from 15 January to 31 March 2017 at National Institute of Health Sciences (NIH) in collaboration with Riphah Institute of Pharmaceutical Sciences (RIPS).
Materials and Methods: Forty healthy Sprague Dawly rats weighing 300-350gms were randomly divided in four groups with 10 rats each. Group A was the control group that received no medications. Group B was given Gentamicin 80mg/ kg body weight / day for 10 days intraperitoneally (IP). Group C was given Gentamicin 80mg/ kg body weight / day IP and Aqueous Extract of Cichorium Intybus seeds 500mg/kg body weight/ day through gavage tube for 10 days. Group D was given Gentamicin 80mg/ kg body weight / day IP and Methanolic Extract of Cichorium Intybus seeds 500mg/kg body weight / day through gavage tube for 10 days. Serum urea and creatinine were measured at day zero, 6, and 11. The values were compared within and between the groups.
Results: Elevated levels of serum urea and creatinine were found in group B indicating renal damage. Whereas administration of Aqueous and Methanolic extracts of Cichorium Intybus seeds reduced the elevated levels of serum urea and creatinine in group C & D. However more reduction was produced in group C.
Conclusion: Concomitant administration of Aqueous and Methanolic extracts of Cichorium Intybus seeds exerted nephroprotective effect on Gentamicin induced nephrotoxicity in rats. Aqueous extract produced greater protection as compared to Methanolic extract. |
| first_indexed | 2024-04-11T19:48:28Z |
| format | Article |
| id | doaj.art-c59fe26ff70f47f798d65cb8cee4da36 |
| institution | Directory Open Access Journal |
| issn | 1815-4018 2410-5422 |
| language | English |
| last_indexed | 2024-04-11T19:48:28Z |
| publishDate | 2018-12-01 |
| publisher | Riphah International University, Islamabad |
| record_format | Article |
| series | Journal of Islamic International Medical College |
| spelling | doaj.art-c59fe26ff70f47f798d65cb8cee4da362022-12-22T04:06:23ZengRiphah International University, IslamabadJournal of Islamic International Medical College1815-40182410-54222018-12-011341841881450Effects of Aqueous and Methanolic Extracts of Cichorium Intybus Seeds on Gentamicin Induced Nephrotoxicity in RatsMuhammad Tahir , Noman Sadiq , Sameer Ahmed , Amanat Ali , Noor Nasir Rajpoot , Uzma RiazObjective: To evaluate the effects of Aqueous and Methanolic extracts of Cichorium Intybus seeds on Gentamicin induced nephrotoxicity in rats. Study Design: Experimental Study Place and Duration of Study: Study was conducted from 15 January to 31 March 2017 at National Institute of Health Sciences (NIH) in collaboration with Riphah Institute of Pharmaceutical Sciences (RIPS). Materials and Methods: Forty healthy Sprague Dawly rats weighing 300-350gms were randomly divided in four groups with 10 rats each. Group A was the control group that received no medications. Group B was given Gentamicin 80mg/ kg body weight / day for 10 days intraperitoneally (IP). Group C was given Gentamicin 80mg/ kg body weight / day IP and Aqueous Extract of Cichorium Intybus seeds 500mg/kg body weight/ day through gavage tube for 10 days. Group D was given Gentamicin 80mg/ kg body weight / day IP and Methanolic Extract of Cichorium Intybus seeds 500mg/kg body weight / day through gavage tube for 10 days. Serum urea and creatinine were measured at day zero, 6, and 11. The values were compared within and between the groups. Results: Elevated levels of serum urea and creatinine were found in group B indicating renal damage. Whereas administration of Aqueous and Methanolic extracts of Cichorium Intybus seeds reduced the elevated levels of serum urea and creatinine in group C & D. However more reduction was produced in group C. Conclusion: Concomitant administration of Aqueous and Methanolic extracts of Cichorium Intybus seeds exerted nephroprotective effect on Gentamicin induced nephrotoxicity in rats. Aqueous extract produced greater protection as compared to Methanolic extract.https://journals.riphah.edu.pk/index.php/jiimc/article/view/1054cichorium intybus seeds, gentamicin, nephroprotective effect, nephrotoxicity. |
| spellingShingle | Muhammad Tahir , Noman Sadiq , Sameer Ahmed , Amanat Ali , Noor Nasir Rajpoot , Uzma Riaz Effects of Aqueous and Methanolic Extracts of Cichorium Intybus Seeds on Gentamicin Induced Nephrotoxicity in Rats Journal of Islamic International Medical College cichorium intybus seeds, gentamicin, nephroprotective effect, nephrotoxicity. |
| title | Effects of Aqueous and Methanolic Extracts of Cichorium Intybus Seeds on Gentamicin Induced Nephrotoxicity in Rats |
| title_full | Effects of Aqueous and Methanolic Extracts of Cichorium Intybus Seeds on Gentamicin Induced Nephrotoxicity in Rats |
| title_fullStr | Effects of Aqueous and Methanolic Extracts of Cichorium Intybus Seeds on Gentamicin Induced Nephrotoxicity in Rats |
| title_full_unstemmed | Effects of Aqueous and Methanolic Extracts of Cichorium Intybus Seeds on Gentamicin Induced Nephrotoxicity in Rats |
| title_short | Effects of Aqueous and Methanolic Extracts of Cichorium Intybus Seeds on Gentamicin Induced Nephrotoxicity in Rats |
| title_sort | effects of aqueous and methanolic extracts of cichorium intybus seeds on gentamicin induced nephrotoxicity in rats |
| topic | cichorium intybus seeds, gentamicin, nephroprotective effect, nephrotoxicity. |
| url | https://journals.riphah.edu.pk/index.php/jiimc/article/view/1054 |
| work_keys_str_mv | AT muhammadtahirnomansadiqsameerahmedamanatalinoornasirrajpootuzmariaz effectsofaqueousandmethanolicextractsofcichoriumintybusseedsongentamicininducednephrotoxicityinrats |