Oligohydramnios and fetal outcome in term pregnancy
Background and objective: Orally disintegrating film is a solid dosage form made as an alternative for tablets for pediatric and geriatric patients who have difficulty in swallowing. These formulations are designed to dissolve in the mouth rapidly upon contact with saliva. This study aimed to prepar...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Hawler Medical University
2020-12-01
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| Series: | Zanco Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://zjms.hmu.edu.krd/index.php/zjms/article/view/791 |
| _version_ | 1818676034583658496 |
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| author | Hazha Azad Ibrahim Zainab Muhsin Zween |
| author_facet | Hazha Azad Ibrahim Zainab Muhsin Zween |
| author_sort | Hazha Azad Ibrahim |
| collection | DOAJ |
| description | Background and objective: Orally disintegrating film is a solid dosage form made as an alternative for tablets for pediatric and geriatric patients who have difficulty in swallowing. These formulations are designed to dissolve in the mouth rapidly upon contact with saliva. This study aimed to prepare a thin oro-dispersible film base that can withstand handling in which a drug can be incorporated to provide a new dosage form.
Methods: The solvent casting method was used to prepare the films, in which the ingredients were mixed, dissolved, and cast in a Petri dish. Then, they were left to dry in the oven overnight. Different concentrations of each of the two polymers alone and combined in different ratios were compared using different concentrations of plasticizer.
Results: Successful, transparent films were prepared from gelatin and glycerin. A combination of 70% gelatin and 30% sodium carboxymethyl cellulose with glycerin formed an acceptable film having white color. The film forming capacity of sodium carboxymethyl cellulose alone was not good. All films were tearing and not well formed. All films that contain polyethylene glycol were brittle. Both superdisintegrants reduced the disintegration time for both films, but kyron was more effective than sodium starch glycolate.
Conclusion: A successful oral film was prepared using different types of polymers, which is suitable for incorporating a potent drug to form a new dosage form that is easily portable and does not require water for swallowing. |
| first_indexed | 2024-12-17T08:37:04Z |
| format | Article |
| id | doaj.art-c59fe97bf6a94643a6ac2ca81323c530 |
| institution | Directory Open Access Journal |
| issn | 1995-5588 1995-5596 |
| language | English |
| last_indexed | 2024-12-17T08:37:04Z |
| publishDate | 2020-12-01 |
| publisher | Hawler Medical University |
| record_format | Article |
| series | Zanco Journal of Medical Sciences |
| spelling | doaj.art-c59fe97bf6a94643a6ac2ca81323c5302022-12-21T21:56:27ZengHawler Medical UniversityZanco Journal of Medical Sciences1995-55881995-55962020-12-0124333834610.15218/zjms.2020.041Oligohydramnios and fetal outcome in term pregnancyHazha Azad Ibrahim0Zainab Muhsin Zween1Maternity Teaching Hospital, Erbil, Iraq.Department of Gynecology and Obstetrics, College of Medicine, Hawler Medical University, Erbil, Iraq.Background and objective: Orally disintegrating film is a solid dosage form made as an alternative for tablets for pediatric and geriatric patients who have difficulty in swallowing. These formulations are designed to dissolve in the mouth rapidly upon contact with saliva. This study aimed to prepare a thin oro-dispersible film base that can withstand handling in which a drug can be incorporated to provide a new dosage form. Methods: The solvent casting method was used to prepare the films, in which the ingredients were mixed, dissolved, and cast in a Petri dish. Then, they were left to dry in the oven overnight. Different concentrations of each of the two polymers alone and combined in different ratios were compared using different concentrations of plasticizer. Results: Successful, transparent films were prepared from gelatin and glycerin. A combination of 70% gelatin and 30% sodium carboxymethyl cellulose with glycerin formed an acceptable film having white color. The film forming capacity of sodium carboxymethyl cellulose alone was not good. All films were tearing and not well formed. All films that contain polyethylene glycol were brittle. Both superdisintegrants reduced the disintegration time for both films, but kyron was more effective than sodium starch glycolate. Conclusion: A successful oral film was prepared using different types of polymers, which is suitable for incorporating a potent drug to form a new dosage form that is easily portable and does not require water for swallowing.https://zjms.hmu.edu.krd/index.php/zjms/article/view/791amniotic fluid indexmaternal outcomefetal outcomeoligohydramnios |
| spellingShingle | Hazha Azad Ibrahim Zainab Muhsin Zween Oligohydramnios and fetal outcome in term pregnancy Zanco Journal of Medical Sciences amniotic fluid index maternal outcome fetal outcome oligohydramnios |
| title | Oligohydramnios and fetal outcome in term pregnancy |
| title_full | Oligohydramnios and fetal outcome in term pregnancy |
| title_fullStr | Oligohydramnios and fetal outcome in term pregnancy |
| title_full_unstemmed | Oligohydramnios and fetal outcome in term pregnancy |
| title_short | Oligohydramnios and fetal outcome in term pregnancy |
| title_sort | oligohydramnios and fetal outcome in term pregnancy |
| topic | amniotic fluid index maternal outcome fetal outcome oligohydramnios |
| url | https://zjms.hmu.edu.krd/index.php/zjms/article/view/791 |
| work_keys_str_mv | AT hazhaazadibrahim oligohydramniosandfetaloutcomeintermpregnancy AT zainabmuhsinzween oligohydramniosandfetaloutcomeintermpregnancy |