Structural Identification of Zotarolimus (ABT-578) Metabolites Generated by Human Liver Microsomes Using Ion-Trap and High-Resolution Time-of-Flight Mass Spectrometry in Combination with the Analysis of Fragmentation Patterns

Structural Identification of Zotarolimus (ABT-578) Metabolites Generated by Human Liver Microsomes Using Ion-Trap and High-Resolution Time-of-Flight Mass Spectrometry in Combination with the Analysis of Fragmentation Patterns

Zotarolimus (ABT-578) is a sirolimus derivative that, like sirolimus and everolimus, is an inhibitor of cell growth via inhibition of the mechanistic target of rapamycin (mTOR). Zotarolimus was developed for coating coronary stents to prevent smooth muscle cell proliferation and restenosis. Albeit z...

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Bibliographic Details
Main Authors: Touraj Shokati, Seth H. Drake, Wanzhu Zhao, Jost Klawitter, Jelena Klawitter, Uwe Christians
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Metabolites
Subjects:
zotarolimus
human liver microsomes
human drug metabolism
metabolite structures
fragmentation patterns
high-resolution time-of-flight mass spectrometry
Online Access:https://www.mdpi.com/2218-1989/13/10/1093

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