Evaluation of Schlemm’s canal with swept-source optical coherence tomography in primary angle-closure disease
Abstract Purpose To perform an in vivo evaluation of the changes in Schlemm’s canal (SC) among patients with primary angle-closure disease (PACD) using swept-source optical coherence tomography (SS-OCT). Methods Patients diagnosed with PACD who had not undergone surgery were recruited. The SS-OCT qu...
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-023-03001-4 |
| _version_ | 1797779005683793920 |
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| author | Xuming Ding Lulu Huang Cheng Peng Li Xu Yixin Liu Yijie Yang Ning Wang Mengyang Gu Chengyang Sun Yue Wu Wenyi Guo |
| author_facet | Xuming Ding Lulu Huang Cheng Peng Li Xu Yixin Liu Yijie Yang Ning Wang Mengyang Gu Chengyang Sun Yue Wu Wenyi Guo |
| author_sort | Xuming Ding |
| collection | DOAJ |
| description | Abstract Purpose To perform an in vivo evaluation of the changes in Schlemm’s canal (SC) among patients with primary angle-closure disease (PACD) using swept-source optical coherence tomography (SS-OCT). Methods Patients diagnosed with PACD who had not undergone surgery were recruited. The SS-OCT quadrants scanned herein included the nasal and temporal sections at 3 and 9 o’clock, respectively. The diameter and cross-sectional area of the SC were measured. A linear mixed-effects model was performed to analyze the effects of parameters on the SC changes. The hypothesis of interest was related to the angle status (iridotrabecular contact, ITC/open angle, OPN), which was further explored with pairwise comparisons of the estimated marginal means (EMMs) of the SC diameter and SC area. In the ITC regions, the relationship between the trabecular-iris contact length (TICL) percentage and SC parameters was also studied by a mixed model. Results A total of 49 eyes of 35 patients were included for measurements and analysis. The percentage of observable SCs in the ITC regions was only 58.5% (24/41), whereas it was 86.0% (49/57) in the OPN regions (χ2 = 9.44, p = 0.002). ITC was significantly associated with a decreasing SC size. The EMMs for the diameter and cross-sectional area of SC at the ITC and OPN regions were 203.34 μm versus 261.41 μm (p = 0.006) and 3174.43 μm2 versus 5347.63 μm2 (p = 0.022), respectively. Sex, age, spherical equivalent refraction, intraocular pressure, axial length, extent of angle closure, history of acute attack and treatment with LPI were not significantly associated with SC parameters. In the ITC regions, a larger TICL percentage was significantly associated with a decrease in SC diameter and area (p = 0.003 and 0.019, respectively). Conclusions The morphologies of SC could be affected by the angle status (ITC/OPN) in patients with PACD, and ITC was significantly associated with a decreasing SC size. These changes in SC as described by OCT scans might help to elucidate the progression mechanisms of PACD. |
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| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-03-12T23:25:32Z |
| publishDate | 2023-06-01 |
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| series | BMC Ophthalmology |
| spelling | doaj.art-c5a116f8a171466e8c4b42dc3cde9f202023-07-16T11:12:38ZengBMCBMC Ophthalmology1471-24152023-06-0123111010.1186/s12886-023-03001-4Evaluation of Schlemm’s canal with swept-source optical coherence tomography in primary angle-closure diseaseXuming Ding0Lulu Huang1Cheng Peng2Li Xu3Yixin Liu4Yijie Yang5Ning Wang6Mengyang Gu7Chengyang Sun8Yue Wu9Wenyi Guo10Department of Ophthalmology, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineAbstract Purpose To perform an in vivo evaluation of the changes in Schlemm’s canal (SC) among patients with primary angle-closure disease (PACD) using swept-source optical coherence tomography (SS-OCT). Methods Patients diagnosed with PACD who had not undergone surgery were recruited. The SS-OCT quadrants scanned herein included the nasal and temporal sections at 3 and 9 o’clock, respectively. The diameter and cross-sectional area of the SC were measured. A linear mixed-effects model was performed to analyze the effects of parameters on the SC changes. The hypothesis of interest was related to the angle status (iridotrabecular contact, ITC/open angle, OPN), which was further explored with pairwise comparisons of the estimated marginal means (EMMs) of the SC diameter and SC area. In the ITC regions, the relationship between the trabecular-iris contact length (TICL) percentage and SC parameters was also studied by a mixed model. Results A total of 49 eyes of 35 patients were included for measurements and analysis. The percentage of observable SCs in the ITC regions was only 58.5% (24/41), whereas it was 86.0% (49/57) in the OPN regions (χ2 = 9.44, p = 0.002). ITC was significantly associated with a decreasing SC size. The EMMs for the diameter and cross-sectional area of SC at the ITC and OPN regions were 203.34 μm versus 261.41 μm (p = 0.006) and 3174.43 μm2 versus 5347.63 μm2 (p = 0.022), respectively. Sex, age, spherical equivalent refraction, intraocular pressure, axial length, extent of angle closure, history of acute attack and treatment with LPI were not significantly associated with SC parameters. In the ITC regions, a larger TICL percentage was significantly associated with a decrease in SC diameter and area (p = 0.003 and 0.019, respectively). Conclusions The morphologies of SC could be affected by the angle status (ITC/OPN) in patients with PACD, and ITC was significantly associated with a decreasing SC size. These changes in SC as described by OCT scans might help to elucidate the progression mechanisms of PACD.https://doi.org/10.1186/s12886-023-03001-4Primary angle closure diseaseSchlemm’s canalIridotrabecular contactOptical coherence tomography |
| spellingShingle | Xuming Ding Lulu Huang Cheng Peng Li Xu Yixin Liu Yijie Yang Ning Wang Mengyang Gu Chengyang Sun Yue Wu Wenyi Guo Evaluation of Schlemm’s canal with swept-source optical coherence tomography in primary angle-closure disease BMC Ophthalmology Primary angle closure disease Schlemm’s canal Iridotrabecular contact Optical coherence tomography |
| title | Evaluation of Schlemm’s canal with swept-source optical coherence tomography in primary angle-closure disease |
| title_full | Evaluation of Schlemm’s canal with swept-source optical coherence tomography in primary angle-closure disease |
| title_fullStr | Evaluation of Schlemm’s canal with swept-source optical coherence tomography in primary angle-closure disease |
| title_full_unstemmed | Evaluation of Schlemm’s canal with swept-source optical coherence tomography in primary angle-closure disease |
| title_short | Evaluation of Schlemm’s canal with swept-source optical coherence tomography in primary angle-closure disease |
| title_sort | evaluation of schlemm s canal with swept source optical coherence tomography in primary angle closure disease |
| topic | Primary angle closure disease Schlemm’s canal Iridotrabecular contact Optical coherence tomography |
| url | https://doi.org/10.1186/s12886-023-03001-4 |
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