THE ROLE OF VITAMIN E (α-TOCOPHEROL) ON TESTOSTERONE LEVEL IN SPRAGUE DAWLEY RATS FOLLOWING CISPLATIN TREATMENT
Objective: To observe the difference of testosterone levels in adult male Sprague Dawley rats treated with combination of cisplatin and vitamin E compared to those treated with cisplatin only. Material & Methods: We used 24 adult male Sprague Dawley rats weight 200–300 grams and randomly assigne...
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| Format: | Article |
| Language: | English |
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IKATAN AHLI UROLOGI INDONESIA
2019-01-01
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| Series: | Jurnal Urologi Indonesia |
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| Online Access: | http://juri.urologi.or.id/juri/article/view/545 |
| _version_ | 1818807070972968960 |
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| author | Dian Kartika Rezia Lukman Hakim Wahjoe Djatisoesanto |
| author_facet | Dian Kartika Rezia Lukman Hakim Wahjoe Djatisoesanto |
| author_sort | Dian Kartika Rezia |
| collection | DOAJ |
| description | Objective: To observe the difference of testosterone levels in adult male Sprague Dawley rats treated with combination of cisplatin and vitamin E compared to those treated with cisplatin only. Material & Methods: We used 24 adult male Sprague Dawley rats weight 200–300 grams and randomly assigned into 4 groups (n=6). Rats in negative control group (NC) were given intraperitoneal normal saline injection, while the positive control (PC) group were injected with cisplatin 5 mg/kgBW at the end of the 3rd week. Two other groups, P1 and P2, were injected with cisplatin 5 mg/kgBW and given vitamin E orally 50 mg/kgBW and 200 mg/kgBW, respectively. Cardiac blood was aspirated at the end of the 7th week and processed for analysis of testosterone levels. Results: We recorded a significantly lower testosterone levels in rats treated only with cisplatin 5 mg/kgBW (CP) compared to those in CN group (p=0.006), and those receiving combination of cisplatin and vitamin E 50 mg/kgBW (p=0.003) and 200 mg/kgBW (p=0.001). Though not significant, testosterone levels were higher in P2 group than in P1 group (p=0.702). Conclusion: Exposure to cisplatin can lower testosterone levels in white rats, and the administration of vitamin E gives protection against such effect. |
| first_indexed | 2024-12-18T19:19:50Z |
| format | Article |
| id | doaj.art-c5a211f0227a45c2a1c0a38b9591ab13 |
| institution | Directory Open Access Journal |
| issn | 0853-442X 2355-1402 |
| language | English |
| last_indexed | 2024-12-18T19:19:50Z |
| publishDate | 2019-01-01 |
| publisher | IKATAN AHLI UROLOGI INDONESIA |
| record_format | Article |
| series | Jurnal Urologi Indonesia |
| spelling | doaj.art-c5a211f0227a45c2a1c0a38b9591ab132022-12-21T20:56:03ZengIKATAN AHLI UROLOGI INDONESIAJurnal Urologi Indonesia0853-442X2355-14022019-01-0126110.32421/juri.v26i1.545545THE ROLE OF VITAMIN E (α-TOCOPHEROL) ON TESTOSTERONE LEVEL IN SPRAGUE DAWLEY RATS FOLLOWING CISPLATIN TREATMENTDian Kartika Rezia0Lukman Hakim1Wahjoe Djatisoesanto2Department of Urology, Faculty of Medicine/Universitas Airlangga, Soetomo General Hospital, Surabaya.Department of Urology, Faculty of Medicine/Universitas Airlangga, Soetomo General Hospital, Surabaya.Department of Urology, Faculty of Medicine/Universitas Airlangga, Soetomo General Hospital, Surabaya.Objective: To observe the difference of testosterone levels in adult male Sprague Dawley rats treated with combination of cisplatin and vitamin E compared to those treated with cisplatin only. Material & Methods: We used 24 adult male Sprague Dawley rats weight 200–300 grams and randomly assigned into 4 groups (n=6). Rats in negative control group (NC) were given intraperitoneal normal saline injection, while the positive control (PC) group were injected with cisplatin 5 mg/kgBW at the end of the 3rd week. Two other groups, P1 and P2, were injected with cisplatin 5 mg/kgBW and given vitamin E orally 50 mg/kgBW and 200 mg/kgBW, respectively. Cardiac blood was aspirated at the end of the 7th week and processed for analysis of testosterone levels. Results: We recorded a significantly lower testosterone levels in rats treated only with cisplatin 5 mg/kgBW (CP) compared to those in CN group (p=0.006), and those receiving combination of cisplatin and vitamin E 50 mg/kgBW (p=0.003) and 200 mg/kgBW (p=0.001). Though not significant, testosterone levels were higher in P2 group than in P1 group (p=0.702). Conclusion: Exposure to cisplatin can lower testosterone levels in white rats, and the administration of vitamin E gives protection against such effect.http://juri.urologi.or.id/juri/article/view/545CisplatinchemotherapyVitamin Eantioxidanttestosteronetestis |
| spellingShingle | Dian Kartika Rezia Lukman Hakim Wahjoe Djatisoesanto THE ROLE OF VITAMIN E (α-TOCOPHEROL) ON TESTOSTERONE LEVEL IN SPRAGUE DAWLEY RATS FOLLOWING CISPLATIN TREATMENT Jurnal Urologi Indonesia Cisplatin chemotherapy Vitamin E antioxidant testosterone testis |
| title | THE ROLE OF VITAMIN E (α-TOCOPHEROL) ON TESTOSTERONE LEVEL IN SPRAGUE DAWLEY RATS FOLLOWING CISPLATIN TREATMENT |
| title_full | THE ROLE OF VITAMIN E (α-TOCOPHEROL) ON TESTOSTERONE LEVEL IN SPRAGUE DAWLEY RATS FOLLOWING CISPLATIN TREATMENT |
| title_fullStr | THE ROLE OF VITAMIN E (α-TOCOPHEROL) ON TESTOSTERONE LEVEL IN SPRAGUE DAWLEY RATS FOLLOWING CISPLATIN TREATMENT |
| title_full_unstemmed | THE ROLE OF VITAMIN E (α-TOCOPHEROL) ON TESTOSTERONE LEVEL IN SPRAGUE DAWLEY RATS FOLLOWING CISPLATIN TREATMENT |
| title_short | THE ROLE OF VITAMIN E (α-TOCOPHEROL) ON TESTOSTERONE LEVEL IN SPRAGUE DAWLEY RATS FOLLOWING CISPLATIN TREATMENT |
| title_sort | role of vitamin e α tocopherol on testosterone level in sprague dawley rats following cisplatin treatment |
| topic | Cisplatin chemotherapy Vitamin E antioxidant testosterone testis |
| url | http://juri.urologi.or.id/juri/article/view/545 |
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