Selective Metal Chelation by a Thiosemicarbazone Derivative Interferes with Mitochondrial Respiration and Ribosome Biogenesis in Candida albicans

Selective Metal Chelation by a Thiosemicarbazone Derivative Interferes with Mitochondrial Respiration and Ribosome Biogenesis in Candida albicans

ABSTRACT Metal chelation is generally considered as a promising antifungal approach but its specific mechanisms are unclear. Here, we identify 13 thiosemicarbazone derivatives that exert broad-spectrum antifungal activity with potency comparable or superior to that of fluconazole in vitro by screeni...

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Bibliographic Details
Main Authors: Ximeng Duan, Zhiyu Xie, Liying Ma, Xueyang Jin, Ming Zhang, Yuliang Xu, Yue Liu, Hongxiang Lou, Wenqiang Chang
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:Microbiology Spectrum
Subjects:
thiosemicarbazone derivatives
antifungal
metal chelator
mitochondrial respiration
ribosome biogenesis
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01951-21

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