Cytopenia after CAR-T Cell Therapy—A Brief Review of a Complex Problem
Chimeric Antigen Receptor T-cell (CAR-T) immunotherapy has emerged as an efficacious and life extending treatment modality with high response rates and durable remissions in patients with relapsed and refractory non-Hodgkin lymphoma (NHL), follicular lymphoma, and B-cell acute lymphoblastic leukemia...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/6/1501 |
| _version_ | 1797446919050493952 |
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| author | Naman Sharma Patrick M. Reagan Jane L. Liesveld |
| author_facet | Naman Sharma Patrick M. Reagan Jane L. Liesveld |
| author_sort | Naman Sharma |
| collection | DOAJ |
| description | Chimeric Antigen Receptor T-cell (CAR-T) immunotherapy has emerged as an efficacious and life extending treatment modality with high response rates and durable remissions in patients with relapsed and refractory non-Hodgkin lymphoma (NHL), follicular lymphoma, and B-cell acute lymphoblastic leukemia (B-ALL) as well as in other diseases. Prolonged or recurrent cytopenias after CAR-T therapy have increasingly been reported at varying rates, and the pathogenesis of this complication is not yet well-understood but is likely contributed to by multiple factors. Current studies reported are primarily retrospective, heterogeneous in terms of CAR-Ts used and diseases treated, non-uniform in definitions of cytopenias and durations for end points, and vary in terms of recommended management. Prospective studies and correlative laboratory studies investigating the pathophysiology of prolonged cytopenias will enhance our understanding of this phenomenon. This review summarizes knowledge of these cytopenias to date. |
| first_indexed | 2024-03-09T13:48:27Z |
| format | Article |
| id | doaj.art-c5a5d4f9d4074b25bd33a0109b96b0a2 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T13:48:27Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-c5a5d4f9d4074b25bd33a0109b96b0a22023-11-30T20:56:18ZengMDPI AGCancers2072-66942022-03-01146150110.3390/cancers14061501Cytopenia after CAR-T Cell Therapy—A Brief Review of a Complex ProblemNaman Sharma0Patrick M. Reagan1Jane L. Liesveld2Department of Hematology-Oncology, Baystate Medical Center, University of Massachusetts Medical School, Springfield, MA 100107, USADepartment of Medicine, Hematology-Oncology, James P. Wilmot Cancer Institute, University of Rochester, Rochester, NY 14642, USADepartment of Medicine, Hematology-Oncology, James P. Wilmot Cancer Institute, University of Rochester, Rochester, NY 14642, USAChimeric Antigen Receptor T-cell (CAR-T) immunotherapy has emerged as an efficacious and life extending treatment modality with high response rates and durable remissions in patients with relapsed and refractory non-Hodgkin lymphoma (NHL), follicular lymphoma, and B-cell acute lymphoblastic leukemia (B-ALL) as well as in other diseases. Prolonged or recurrent cytopenias after CAR-T therapy have increasingly been reported at varying rates, and the pathogenesis of this complication is not yet well-understood but is likely contributed to by multiple factors. Current studies reported are primarily retrospective, heterogeneous in terms of CAR-Ts used and diseases treated, non-uniform in definitions of cytopenias and durations for end points, and vary in terms of recommended management. Prospective studies and correlative laboratory studies investigating the pathophysiology of prolonged cytopenias will enhance our understanding of this phenomenon. This review summarizes knowledge of these cytopenias to date.https://www.mdpi.com/2072-6694/14/6/1501chimeric antigen receptor T-cell (CAR-T)prolonged cytopeniacytokines |
| spellingShingle | Naman Sharma Patrick M. Reagan Jane L. Liesveld Cytopenia after CAR-T Cell Therapy—A Brief Review of a Complex Problem Cancers chimeric antigen receptor T-cell (CAR-T) prolonged cytopenia cytokines |
| title | Cytopenia after CAR-T Cell Therapy—A Brief Review of a Complex Problem |
| title_full | Cytopenia after CAR-T Cell Therapy—A Brief Review of a Complex Problem |
| title_fullStr | Cytopenia after CAR-T Cell Therapy—A Brief Review of a Complex Problem |
| title_full_unstemmed | Cytopenia after CAR-T Cell Therapy—A Brief Review of a Complex Problem |
| title_short | Cytopenia after CAR-T Cell Therapy—A Brief Review of a Complex Problem |
| title_sort | cytopenia after car t cell therapy a brief review of a complex problem |
| topic | chimeric antigen receptor T-cell (CAR-T) prolonged cytopenia cytokines |
| url | https://www.mdpi.com/2072-6694/14/6/1501 |
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