Potential Diets to Improve Mitochondrial Activity in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease, the pathogenesis of which is based on alternations in the mitochondria of motor neurons, causing their progressive death. A growing body of evidence shows that more efficient mitophagy could prevent and/or treat this diso...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Diseases |
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| Online Access: | https://www.mdpi.com/2079-9721/10/4/117 |
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| author | Sayuri Yoshikawa Kurumi Taniguchi Haruka Sawamura Yuka Ikeda Ai Tsuji Satoru Matsuda |
| author_facet | Sayuri Yoshikawa Kurumi Taniguchi Haruka Sawamura Yuka Ikeda Ai Tsuji Satoru Matsuda |
| author_sort | Sayuri Yoshikawa |
| collection | DOAJ |
| description | Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease, the pathogenesis of which is based on alternations in the mitochondria of motor neurons, causing their progressive death. A growing body of evidence shows that more efficient mitophagy could prevent and/or treat this disorder by suppressing mitochondrial dysfunction-induced oxidative stress and inflammation. Mitophagy has been considered one of the main mechanisms responsible for mitochondrial quality control. Since ALS is characterized by enormous oxidative stress, several edible phytochemicals that can activate mitophagy to remove damaged mitochondria could be considered a promising option to treat ALS by providing neuroprotection. Therefore, it is of great significance to explore the mechanisms of mitophagy in ALS and to understand the effects and/or molecular mechanisms of phytochemical action, which could translate into a treatment for neurodegenerative diseases, including ALS. |
| first_indexed | 2024-03-09T17:07:46Z |
| format | Article |
| id | doaj.art-c5a8425b96da4d6ca5c49cae60177ab2 |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-03-09T17:07:46Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-c5a8425b96da4d6ca5c49cae60177ab22023-11-24T14:21:49ZengMDPI AGDiseases2079-97212022-12-0110411710.3390/diseases10040117Potential Diets to Improve Mitochondrial Activity in Amyotrophic Lateral SclerosisSayuri Yoshikawa0Kurumi Taniguchi1Haruka Sawamura2Yuka Ikeda3Ai Tsuji4Satoru Matsuda5Department of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, JapanAmyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease, the pathogenesis of which is based on alternations in the mitochondria of motor neurons, causing their progressive death. A growing body of evidence shows that more efficient mitophagy could prevent and/or treat this disorder by suppressing mitochondrial dysfunction-induced oxidative stress and inflammation. Mitophagy has been considered one of the main mechanisms responsible for mitochondrial quality control. Since ALS is characterized by enormous oxidative stress, several edible phytochemicals that can activate mitophagy to remove damaged mitochondria could be considered a promising option to treat ALS by providing neuroprotection. Therefore, it is of great significance to explore the mechanisms of mitophagy in ALS and to understand the effects and/or molecular mechanisms of phytochemical action, which could translate into a treatment for neurodegenerative diseases, including ALS.https://www.mdpi.com/2079-9721/10/4/117ALSmitophagyROSAMPKmTORmTORC1 |
| spellingShingle | Sayuri Yoshikawa Kurumi Taniguchi Haruka Sawamura Yuka Ikeda Ai Tsuji Satoru Matsuda Potential Diets to Improve Mitochondrial Activity in Amyotrophic Lateral Sclerosis Diseases ALS mitophagy ROS AMPK mTOR mTORC1 |
| title | Potential Diets to Improve Mitochondrial Activity in Amyotrophic Lateral Sclerosis |
| title_full | Potential Diets to Improve Mitochondrial Activity in Amyotrophic Lateral Sclerosis |
| title_fullStr | Potential Diets to Improve Mitochondrial Activity in Amyotrophic Lateral Sclerosis |
| title_full_unstemmed | Potential Diets to Improve Mitochondrial Activity in Amyotrophic Lateral Sclerosis |
| title_short | Potential Diets to Improve Mitochondrial Activity in Amyotrophic Lateral Sclerosis |
| title_sort | potential diets to improve mitochondrial activity in amyotrophic lateral sclerosis |
| topic | ALS mitophagy ROS AMPK mTOR mTORC1 |
| url | https://www.mdpi.com/2079-9721/10/4/117 |
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