Alcohol increases treatment failure for Helicobacter pylori eradication in Asian populations
Abstract Background and Aim Whether alcohol intake is associated with Helicobacter pylori (H. pylori) eradication failure remains controversial, and this meta-analysis was aimed at investigating the effect of alcohol on the risk of H. pylori eradication failure. Methods Relevant studies were systema...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-023-03002-z |
| _version_ | 1797559357775282176 |
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| author | Jing Yu Yiming Lv Peng Yang Yizhou Jiang Xiangrong Qin Xiaoyong Wang |
| author_facet | Jing Yu Yiming Lv Peng Yang Yizhou Jiang Xiangrong Qin Xiaoyong Wang |
| author_sort | Jing Yu |
| collection | DOAJ |
| description | Abstract Background and Aim Whether alcohol intake is associated with Helicobacter pylori (H. pylori) eradication failure remains controversial, and this meta-analysis was aimed at investigating the effect of alcohol on the risk of H. pylori eradication failure. Methods Relevant studies were systematically screened for and retrieved from PubMed and Web of Science (updated to January 2022), and relevant references were manually reviewed. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Subgroup, publication bias, and sensitivity analyses were also conducted. Results A total of 40 studies were included in the meta-analysis. No significant association was found between alcohol consumption and the risk of H. pylori eradication failure (OR = 1.09, 95% CI, 0.94–1.26). However, in subgroup analyses stratified by region, a positive association was found in Asian patients (OR = 1.23, 95% CI, 1.03–1.47). In Asian patients, alcohol consumption was associated with the risk of H. pylori eradication failure when the duration of therapy was > 7 days (OR = 1.17, 95% CI, 1.10–1.25), when the treatment regimen included nitroimidazoles (OR = 1.16, 95% CI, 1.09–1.24), and when patients were treated with bismuth-containing quadruple therapy (OR = 1.17, 95% CI, 1.10–1.25). Alcohol intake > 40 g/day was associated with H. pylori eradication failure (OR = 3.17, 95% CI, 1.56–6.41). Moreover, in Asian patients who were administered a vonoprazan (VPZ)-based therapy regimen, alcohol consumption had no effect on H. pylori eradication rates (OR = 1.73, 95% CI, 0.98–3.05). Conclusion Our meta-analysis clearly showed that a higher daily alcohol intake was associated with a higher risk of H. pylori eradication failure in Asian populations. Moreover, a VPZ-based treatment regimen can prevent this effect. |
| first_indexed | 2024-03-10T17:44:14Z |
| format | Article |
| id | doaj.art-c5a850df4a7e484a8c2061d918ad6bde |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-03-10T17:44:14Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-c5a850df4a7e484a8c2061d918ad6bde2023-11-20T09:35:45ZengBMCBMC Gastroenterology1471-230X2023-10-0123111310.1186/s12876-023-03002-zAlcohol increases treatment failure for Helicobacter pylori eradication in Asian populationsJing Yu0Yiming Lv1Peng Yang2Yizhou Jiang3Xiangrong Qin4Xiaoyong Wang5Department of Gastroenterology, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical UniversityDepartment of Gastroenterology, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical UniversityDepartment of Gastroenterology, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical UniversityDepartment of Gastroenterology, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical UniversityDepartment of Gastroenterology, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical UniversityDepartment of Gastroenterology, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical UniversityAbstract Background and Aim Whether alcohol intake is associated with Helicobacter pylori (H. pylori) eradication failure remains controversial, and this meta-analysis was aimed at investigating the effect of alcohol on the risk of H. pylori eradication failure. Methods Relevant studies were systematically screened for and retrieved from PubMed and Web of Science (updated to January 2022), and relevant references were manually reviewed. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Subgroup, publication bias, and sensitivity analyses were also conducted. Results A total of 40 studies were included in the meta-analysis. No significant association was found between alcohol consumption and the risk of H. pylori eradication failure (OR = 1.09, 95% CI, 0.94–1.26). However, in subgroup analyses stratified by region, a positive association was found in Asian patients (OR = 1.23, 95% CI, 1.03–1.47). In Asian patients, alcohol consumption was associated with the risk of H. pylori eradication failure when the duration of therapy was > 7 days (OR = 1.17, 95% CI, 1.10–1.25), when the treatment regimen included nitroimidazoles (OR = 1.16, 95% CI, 1.09–1.24), and when patients were treated with bismuth-containing quadruple therapy (OR = 1.17, 95% CI, 1.10–1.25). Alcohol intake > 40 g/day was associated with H. pylori eradication failure (OR = 3.17, 95% CI, 1.56–6.41). Moreover, in Asian patients who were administered a vonoprazan (VPZ)-based therapy regimen, alcohol consumption had no effect on H. pylori eradication rates (OR = 1.73, 95% CI, 0.98–3.05). Conclusion Our meta-analysis clearly showed that a higher daily alcohol intake was associated with a higher risk of H. pylori eradication failure in Asian populations. Moreover, a VPZ-based treatment regimen can prevent this effect.https://doi.org/10.1186/s12876-023-03002-zHelicobacter pylori eradicationAlcohol consumptionAsian populationsVonoprazan |
| spellingShingle | Jing Yu Yiming Lv Peng Yang Yizhou Jiang Xiangrong Qin Xiaoyong Wang Alcohol increases treatment failure for Helicobacter pylori eradication in Asian populations BMC Gastroenterology Helicobacter pylori eradication Alcohol consumption Asian populations Vonoprazan |
| title | Alcohol increases treatment failure for Helicobacter pylori eradication in Asian populations |
| title_full | Alcohol increases treatment failure for Helicobacter pylori eradication in Asian populations |
| title_fullStr | Alcohol increases treatment failure for Helicobacter pylori eradication in Asian populations |
| title_full_unstemmed | Alcohol increases treatment failure for Helicobacter pylori eradication in Asian populations |
| title_short | Alcohol increases treatment failure for Helicobacter pylori eradication in Asian populations |
| title_sort | alcohol increases treatment failure for helicobacter pylori eradication in asian populations |
| topic | Helicobacter pylori eradication Alcohol consumption Asian populations Vonoprazan |
| url | https://doi.org/10.1186/s12876-023-03002-z |
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