Anti-Inflammatory Effects of Phenolic Compounds Isolated from <i>Quercus Mongolica</i> Fisch. ex Ledeb. on UVB-Irradiated Human Skin Cells
<i>Quercus mongolica</i> Fisch. ex Ledeb. (QM) has been used as an oriental traditional medicine to relieve hemorrhoids, fever, and enteritis. We screened the inhibitory activities of the extracts and compounds (<b>1</b>−<b>6</b>) isolated from QM on the...
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MDPI AG
2019-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/17/3094 |
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| author | Jun Yin Han Hyuk Kim In Hyeok Hwang Dong Hee Kim Min Won Lee |
| author_facet | Jun Yin Han Hyuk Kim In Hyeok Hwang Dong Hee Kim Min Won Lee |
| author_sort | Jun Yin |
| collection | DOAJ |
| description | <i>Quercus mongolica</i> Fisch. ex Ledeb. (QM) has been used as an oriental traditional medicine to relieve hemorrhoids, fever, and enteritis. We screened the inhibitory activities of the extracts and compounds (<b>1</b>−<b>6</b>) isolated from QM on the production of inflammatory cytokines and chemokines to evaluate their anti-inflammatory activities. Further, we evaluated the expression levels of cytokines, chemokines, and immune factors on pedunculagin (PC, <b>1</b>), which was selected from isolated compounds (<b>1</b>−<b>6</b>) because of its potential anti-inflammation effect. Additionally, we evaluated whether the inflammation mitigation effects of PC (<b>1</b>) following UVB exposure in keratinocytes occurred because of nuclear factor (NF)-κB and signal transducer and activator of transcription (STAT)/Janus kinase (JAK) activation. PC (<b>1</b>) remarkably suppressed interleukin (IL)-6, IL-10, IL-13, and monocyte chemoattractant protein-1 (MCP-1) mRNA expression and reduced the mRNA expression level of Cyclooxygenase-2 (COX-2) and also reduced the phosphorylation of p38 mitogen-activated protein kinases (p38), c-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinase (ERK) in a concentration-dependent manner. |
| first_indexed | 2024-12-20T14:32:06Z |
| format | Article |
| id | doaj.art-c5a94ce9b3ea4030aad8d72cdc23b22c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-20T14:32:06Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c5a94ce9b3ea4030aad8d72cdc23b22c2022-12-21T19:37:35ZengMDPI AGMolecules1420-30492019-08-012417309410.3390/molecules24173094molecules24173094Anti-Inflammatory Effects of Phenolic Compounds Isolated from <i>Quercus Mongolica</i> Fisch. ex Ledeb. on UVB-Irradiated Human Skin CellsJun Yin0Han Hyuk Kim1In Hyeok Hwang2Dong Hee Kim3Min Won Lee4Department of Pharmacognosy and Natural product-derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156-756, KoreaDepartment of Pharmacognosy and Natural product-derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156-756, KoreaDepartment of Pharmacognosy and Natural product-derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156-756, KoreaR&D Department Applied Product Development Team, Traditional Korean Medicine Technology Division, 94, Hwarang-ro(Gapje-dong), Gyeongsan-si, Gyeongsangbuk-do 38540, KoreaDepartment of Pharmacognosy and Natural product-derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea<i>Quercus mongolica</i> Fisch. ex Ledeb. (QM) has been used as an oriental traditional medicine to relieve hemorrhoids, fever, and enteritis. We screened the inhibitory activities of the extracts and compounds (<b>1</b>−<b>6</b>) isolated from QM on the production of inflammatory cytokines and chemokines to evaluate their anti-inflammatory activities. Further, we evaluated the expression levels of cytokines, chemokines, and immune factors on pedunculagin (PC, <b>1</b>), which was selected from isolated compounds (<b>1</b>−<b>6</b>) because of its potential anti-inflammation effect. Additionally, we evaluated whether the inflammation mitigation effects of PC (<b>1</b>) following UVB exposure in keratinocytes occurred because of nuclear factor (NF)-κB and signal transducer and activator of transcription (STAT)/Janus kinase (JAK) activation. PC (<b>1</b>) remarkably suppressed interleukin (IL)-6, IL-10, IL-13, and monocyte chemoattractant protein-1 (MCP-1) mRNA expression and reduced the mRNA expression level of Cyclooxygenase-2 (COX-2) and also reduced the phosphorylation of p38 mitogen-activated protein kinases (p38), c-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinase (ERK) in a concentration-dependent manner.https://www.mdpi.com/1420-3049/24/17/3094<i>Quercus mongolica</i> Fisch. ex Ledeb.pedunculaginskin inflammation disease |
| spellingShingle | Jun Yin Han Hyuk Kim In Hyeok Hwang Dong Hee Kim Min Won Lee Anti-Inflammatory Effects of Phenolic Compounds Isolated from <i>Quercus Mongolica</i> Fisch. ex Ledeb. on UVB-Irradiated Human Skin Cells Molecules <i>Quercus mongolica</i> Fisch. ex Ledeb. pedunculagin skin inflammation disease |
| title | Anti-Inflammatory Effects of Phenolic Compounds Isolated from <i>Quercus Mongolica</i> Fisch. ex Ledeb. on UVB-Irradiated Human Skin Cells |
| title_full | Anti-Inflammatory Effects of Phenolic Compounds Isolated from <i>Quercus Mongolica</i> Fisch. ex Ledeb. on UVB-Irradiated Human Skin Cells |
| title_fullStr | Anti-Inflammatory Effects of Phenolic Compounds Isolated from <i>Quercus Mongolica</i> Fisch. ex Ledeb. on UVB-Irradiated Human Skin Cells |
| title_full_unstemmed | Anti-Inflammatory Effects of Phenolic Compounds Isolated from <i>Quercus Mongolica</i> Fisch. ex Ledeb. on UVB-Irradiated Human Skin Cells |
| title_short | Anti-Inflammatory Effects of Phenolic Compounds Isolated from <i>Quercus Mongolica</i> Fisch. ex Ledeb. on UVB-Irradiated Human Skin Cells |
| title_sort | anti inflammatory effects of phenolic compounds isolated from i quercus mongolica i fisch ex ledeb on uvb irradiated human skin cells |
| topic | <i>Quercus mongolica</i> Fisch. ex Ledeb. pedunculagin skin inflammation disease |
| url | https://www.mdpi.com/1420-3049/24/17/3094 |
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