Retinopathy of prematurity in preterm infants born following assisted conception versus spontaneously conceived pregnancies – A 2-year retrospective observational study from an urban tertiary eye care referral center in South India
Purpose: The aim of this study is to determine if in vitro fertilization (IVF) is associated with an increase in the incidence of retinopathy of prematurity (ROP) among preterm infants. Methods: This retrospective, comparative study included all the preterm babies who were screened under an urban...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=2;spage=408;epage=410;aulast=Dabir |
| _version_ | 1797775176626077696 |
|---|---|
| author | Supriya Dabir Arthi Mohankumar D V Srivatsa Sivakumar Munusamy T T JM Berendschot Mohan Rajan Rajvardhan Azad |
| author_facet | Supriya Dabir Arthi Mohankumar D V Srivatsa Sivakumar Munusamy T T JM Berendschot Mohan Rajan Rajvardhan Azad |
| author_sort | Supriya Dabir |
| collection | DOAJ |
| description | Purpose: The aim of this study is to determine if in vitro fertilization (IVF) is associated with an increase in the incidence of retinopathy of prematurity (ROP) among preterm infants. Methods: This retrospective, comparative study included all the preterm babies who were screened under an urban multicentric outreach project between April 2019 and August 2022. Infant details including gender, birth weight, mode of conception, single or multiple gestation, gestational age and post-menstrual age in weeks, age at presentation, and any presence of risk factors were recorded and analyzed. Results: Among 444 preterm babies included in the study, 373 (84%) were conceived normally and 71 (16%) were conceived by IVF. ROP was found in 99 (22.29%) babies in total. There was no significant difference in the incidence of any stage of ROP between the two groups; however, higher stages of ROP were found to be relatively more frequent in the spontaneous conception group in our study. We also found a statistically significant difference in the presence of ROP among singletons, twins, and triplets. Conclusion: IVF was found not to independently increase the risk of ROP in preterm infants. More prospective studies and randomized controlled trials are needed to establish the relationship between the mode of conception and development of severe ROP in preterm infants. |
| first_indexed | 2024-03-12T22:31:58Z |
| format | Article |
| id | doaj.art-c5a9f084689a442791d6e68f79cb6ba8 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-03-12T22:31:58Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-c5a9f084689a442791d6e68f79cb6ba82023-07-21T15:04:35ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892023-01-0171240841010.4103/ijo.IJO_1712_22Retinopathy of prematurity in preterm infants born following assisted conception versus spontaneously conceived pregnancies – A 2-year retrospective observational study from an urban tertiary eye care referral center in South IndiaSupriya DabirArthi MohankumarD V SrivatsaSivakumar MunusamyT T JM BerendschotMohan RajanRajvardhan AzadPurpose: The aim of this study is to determine if in vitro fertilization (IVF) is associated with an increase in the incidence of retinopathy of prematurity (ROP) among preterm infants. Methods: This retrospective, comparative study included all the preterm babies who were screened under an urban multicentric outreach project between April 2019 and August 2022. Infant details including gender, birth weight, mode of conception, single or multiple gestation, gestational age and post-menstrual age in weeks, age at presentation, and any presence of risk factors were recorded and analyzed. Results: Among 444 preterm babies included in the study, 373 (84%) were conceived normally and 71 (16%) were conceived by IVF. ROP was found in 99 (22.29%) babies in total. There was no significant difference in the incidence of any stage of ROP between the two groups; however, higher stages of ROP were found to be relatively more frequent in the spontaneous conception group in our study. We also found a statistically significant difference in the presence of ROP among singletons, twins, and triplets. Conclusion: IVF was found not to independently increase the risk of ROP in preterm infants. More prospective studies and randomized controlled trials are needed to establish the relationship between the mode of conception and development of severe ROP in preterm infants.http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=2;spage=408;epage=410;aulast=Dabirassisted reproductive technologyin vitro fertilizationpreterm birthretinopathy of prematurity |
| spellingShingle | Supriya Dabir Arthi Mohankumar D V Srivatsa Sivakumar Munusamy T T JM Berendschot Mohan Rajan Rajvardhan Azad Retinopathy of prematurity in preterm infants born following assisted conception versus spontaneously conceived pregnancies – A 2-year retrospective observational study from an urban tertiary eye care referral center in South India Indian Journal of Ophthalmology assisted reproductive technology in vitro fertilization preterm birth retinopathy of prematurity |
| title | Retinopathy of prematurity in preterm infants born following assisted conception versus spontaneously conceived pregnancies – A 2-year retrospective observational study from an urban tertiary eye care referral center in South India |
| title_full | Retinopathy of prematurity in preterm infants born following assisted conception versus spontaneously conceived pregnancies – A 2-year retrospective observational study from an urban tertiary eye care referral center in South India |
| title_fullStr | Retinopathy of prematurity in preterm infants born following assisted conception versus spontaneously conceived pregnancies – A 2-year retrospective observational study from an urban tertiary eye care referral center in South India |
| title_full_unstemmed | Retinopathy of prematurity in preterm infants born following assisted conception versus spontaneously conceived pregnancies – A 2-year retrospective observational study from an urban tertiary eye care referral center in South India |
| title_short | Retinopathy of prematurity in preterm infants born following assisted conception versus spontaneously conceived pregnancies – A 2-year retrospective observational study from an urban tertiary eye care referral center in South India |
| title_sort | retinopathy of prematurity in preterm infants born following assisted conception versus spontaneously conceived pregnancies a 2 year retrospective observational study from an urban tertiary eye care referral center in south india |
| topic | assisted reproductive technology in vitro fertilization preterm birth retinopathy of prematurity |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=2;spage=408;epage=410;aulast=Dabir |
| work_keys_str_mv | AT supriyadabir retinopathyofprematurityinpreterminfantsbornfollowingassistedconceptionversusspontaneouslyconceivedpregnanciesa2yearretrospectiveobservationalstudyfromanurbantertiaryeyecarereferralcenterinsouthindia AT arthimohankumar retinopathyofprematurityinpreterminfantsbornfollowingassistedconceptionversusspontaneouslyconceivedpregnanciesa2yearretrospectiveobservationalstudyfromanurbantertiaryeyecarereferralcenterinsouthindia AT dvsrivatsa retinopathyofprematurityinpreterminfantsbornfollowingassistedconceptionversusspontaneouslyconceivedpregnanciesa2yearretrospectiveobservationalstudyfromanurbantertiaryeyecarereferralcenterinsouthindia AT sivakumarmunusamy retinopathyofprematurityinpreterminfantsbornfollowingassistedconceptionversusspontaneouslyconceivedpregnanciesa2yearretrospectiveobservationalstudyfromanurbantertiaryeyecarereferralcenterinsouthindia AT ttjmberendschot retinopathyofprematurityinpreterminfantsbornfollowingassistedconceptionversusspontaneouslyconceivedpregnanciesa2yearretrospectiveobservationalstudyfromanurbantertiaryeyecarereferralcenterinsouthindia AT mohanrajan retinopathyofprematurityinpreterminfantsbornfollowingassistedconceptionversusspontaneouslyconceivedpregnanciesa2yearretrospectiveobservationalstudyfromanurbantertiaryeyecarereferralcenterinsouthindia AT rajvardhanazad retinopathyofprematurityinpreterminfantsbornfollowingassistedconceptionversusspontaneouslyconceivedpregnanciesa2yearretrospectiveobservationalstudyfromanurbantertiaryeyecarereferralcenterinsouthindia |