Benefits of Substituting Sitting with Standing and Walking in Free-Living Conditions for Cardiometabolic Risk Markers, Cognition and Mood in Overweight Adults
Background: We investigated whether substituting sitting with standing and self-perceived light walking in free-living conditions would improve cardiometabolic risk factors, mood, and cognition in overweight/obese adults.Methods: In a randomized, cross-over study, 24 (m/f: 13/11) sedentary overweigh...
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| Format: | Article |
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Frontiers Media S.A.
2017-06-01
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| Series: | Frontiers in Physiology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphys.2017.00353/full |
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| author | Bernard M. F. M. Duvivier Bernard M. F. M. Duvivier Bernard M. F. M. Duvivier Nicolaas C. Schaper Nicolaas C. Schaper Annemarie Koster Annemarie Koster Linh van Kan Harry P. F. Peters Jos J. Adam Timo Giesbrecht Esther Kornips Martine Hulsbosch Paul Willems Matthijs K. C. Hesselink Patrick Schrauwen Hans H. C. M. Savelberg |
| author_facet | Bernard M. F. M. Duvivier Bernard M. F. M. Duvivier Bernard M. F. M. Duvivier Nicolaas C. Schaper Nicolaas C. Schaper Annemarie Koster Annemarie Koster Linh van Kan Harry P. F. Peters Jos J. Adam Timo Giesbrecht Esther Kornips Martine Hulsbosch Paul Willems Matthijs K. C. Hesselink Patrick Schrauwen Hans H. C. M. Savelberg |
| author_sort | Bernard M. F. M. Duvivier |
| collection | DOAJ |
| description | Background: We investigated whether substituting sitting with standing and self-perceived light walking in free-living conditions would improve cardiometabolic risk factors, mood, and cognition in overweight/obese adults.Methods: In a randomized, cross-over study, 24 (m/f: 13/11) sedentary overweight/obese participants (64 ± 7 years, BMI 29 ± 2 kg/m2) followed two activity regimens of each 4 days in free-living conditions: “Sit”: sitting 13.5 h/day, standing 1.4 h/day, self-perceived light-intensity walking 0.7 h/day; for “SitLess” these activities lasted 7.6, 4.0, and 4.3 h/day, respectively. Meals were standardized and physical activity was assessed by accelerometry (activPAL). Insulin sensitivity (expressed as Matsuda-index based on an oral glucose tolerance test), circulating lipids, blood pressure, mood (pleasantness and arousal), and cognition were assessed on the morning after the activity regimens. Quality of life and sleep were assessed on the last day of the activity regimens.Results: We observed that AUC (0–190 min) for insulin decreased by 20% after SitLess vs. Sit [10,125 (656) vs. 12,633 (818); p = 0.006]. Insulin sensitivity improved by 16% after SitLess vs. Sit [Matsuda-index, mean (SEM): 6.45 (0.25) vs. 5.58 (0.25) respectively; p = 0.007]. Fasting triglycerides, non-HDL-cholesterol, and apolipoprotein B decreased by 32, 7, and 4% respectively, whereas HDL-cholesterol increased by 7% after SitLess vs. Sit (all p < 0.01). Diastolic blood pressure was lower after SitLess vs. Sit (p < 0.05). Pleasantness (as one marker of mood status) after the oral glucose tolerance test was higher after SitLess vs. Sit (p < 0.05). There was no significant difference between regimens for cognition, quality of life and sleep.Conclusions: Reducing sitting time in free-living conditions markedly improved insulin sensitivity, circulating lipids, and diastolic blood pressure. Substituting sitting with standing and self-perceived light walking is an effective strategy to improve cardiometabolic risk factors in overweight/obese subjects. |
| first_indexed | 2024-12-23T03:17:49Z |
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| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-23T03:17:49Z |
| publishDate | 2017-06-01 |
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| series | Frontiers in Physiology |
| spelling | doaj.art-c5abaa16215f406ab14ccf51d4d5408f2022-12-21T18:02:03ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2017-06-01810.3389/fphys.2017.00353266626Benefits of Substituting Sitting with Standing and Walking in Free-Living Conditions for Cardiometabolic Risk Markers, Cognition and Mood in Overweight AdultsBernard M. F. M. Duvivier0Bernard M. F. M. Duvivier1Bernard M. F. M. Duvivier2Nicolaas C. Schaper3Nicolaas C. Schaper4Annemarie Koster5Annemarie Koster6Linh van Kan7Harry P. F. Peters8Jos J. Adam9Timo Giesbrecht10Esther Kornips11Martine Hulsbosch12Paul Willems13Matthijs K. C. Hesselink14Patrick Schrauwen15Hans H. C. M. Savelberg16Department Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+Maastricht, NetherlandsDivision Endocrinology, Department Internal Medicine, CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre+Maastricht, NetherlandsCAPHRI School for Public Health and Primary Care, Maastricht University Medical Centre+Maastricht, NetherlandsDivision Endocrinology, Department Internal Medicine, CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre+Maastricht, NetherlandsCAPHRI School for Public Health and Primary Care, Maastricht University Medical Centre+Maastricht, NetherlandsCAPHRI School for Public Health and Primary Care, Maastricht University Medical Centre+Maastricht, NetherlandsDepartment Social Medicine, Maastricht University Medical Centre+Maastricht, NetherlandsDepartment Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+Maastricht, NetherlandsUnilever Research and DevelopmentVlaardingen, NetherlandsDepartment Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+Maastricht, NetherlandsUnilever Research and DevelopmentPort Sunlight, United KingdomDepartment Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+Maastricht, NetherlandsDepartment Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+Maastricht, NetherlandsDepartment Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+Maastricht, NetherlandsDepartment Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+Maastricht, NetherlandsDepartment Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+Maastricht, NetherlandsDepartment Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+Maastricht, NetherlandsBackground: We investigated whether substituting sitting with standing and self-perceived light walking in free-living conditions would improve cardiometabolic risk factors, mood, and cognition in overweight/obese adults.Methods: In a randomized, cross-over study, 24 (m/f: 13/11) sedentary overweight/obese participants (64 ± 7 years, BMI 29 ± 2 kg/m2) followed two activity regimens of each 4 days in free-living conditions: “Sit”: sitting 13.5 h/day, standing 1.4 h/day, self-perceived light-intensity walking 0.7 h/day; for “SitLess” these activities lasted 7.6, 4.0, and 4.3 h/day, respectively. Meals were standardized and physical activity was assessed by accelerometry (activPAL). Insulin sensitivity (expressed as Matsuda-index based on an oral glucose tolerance test), circulating lipids, blood pressure, mood (pleasantness and arousal), and cognition were assessed on the morning after the activity regimens. Quality of life and sleep were assessed on the last day of the activity regimens.Results: We observed that AUC (0–190 min) for insulin decreased by 20% after SitLess vs. Sit [10,125 (656) vs. 12,633 (818); p = 0.006]. Insulin sensitivity improved by 16% after SitLess vs. Sit [Matsuda-index, mean (SEM): 6.45 (0.25) vs. 5.58 (0.25) respectively; p = 0.007]. Fasting triglycerides, non-HDL-cholesterol, and apolipoprotein B decreased by 32, 7, and 4% respectively, whereas HDL-cholesterol increased by 7% after SitLess vs. Sit (all p < 0.01). Diastolic blood pressure was lower after SitLess vs. Sit (p < 0.05). Pleasantness (as one marker of mood status) after the oral glucose tolerance test was higher after SitLess vs. Sit (p < 0.05). There was no significant difference between regimens for cognition, quality of life and sleep.Conclusions: Reducing sitting time in free-living conditions markedly improved insulin sensitivity, circulating lipids, and diastolic blood pressure. Substituting sitting with standing and self-perceived light walking is an effective strategy to improve cardiometabolic risk factors in overweight/obese subjects.http://journal.frontiersin.org/article/10.3389/fphys.2017.00353/fullexerciseinsulin sensitivitylight-intensity physical activitylipidssedentary behaviorsitting |
| spellingShingle | Bernard M. F. M. Duvivier Bernard M. F. M. Duvivier Bernard M. F. M. Duvivier Nicolaas C. Schaper Nicolaas C. Schaper Annemarie Koster Annemarie Koster Linh van Kan Harry P. F. Peters Jos J. Adam Timo Giesbrecht Esther Kornips Martine Hulsbosch Paul Willems Matthijs K. C. Hesselink Patrick Schrauwen Hans H. C. M. Savelberg Benefits of Substituting Sitting with Standing and Walking in Free-Living Conditions for Cardiometabolic Risk Markers, Cognition and Mood in Overweight Adults Frontiers in Physiology exercise insulin sensitivity light-intensity physical activity lipids sedentary behavior sitting |
| title | Benefits of Substituting Sitting with Standing and Walking in Free-Living Conditions for Cardiometabolic Risk Markers, Cognition and Mood in Overweight Adults |
| title_full | Benefits of Substituting Sitting with Standing and Walking in Free-Living Conditions for Cardiometabolic Risk Markers, Cognition and Mood in Overweight Adults |
| title_fullStr | Benefits of Substituting Sitting with Standing and Walking in Free-Living Conditions for Cardiometabolic Risk Markers, Cognition and Mood in Overweight Adults |
| title_full_unstemmed | Benefits of Substituting Sitting with Standing and Walking in Free-Living Conditions for Cardiometabolic Risk Markers, Cognition and Mood in Overweight Adults |
| title_short | Benefits of Substituting Sitting with Standing and Walking in Free-Living Conditions for Cardiometabolic Risk Markers, Cognition and Mood in Overweight Adults |
| title_sort | benefits of substituting sitting with standing and walking in free living conditions for cardiometabolic risk markers cognition and mood in overweight adults |
| topic | exercise insulin sensitivity light-intensity physical activity lipids sedentary behavior sitting |
| url | http://journal.frontiersin.org/article/10.3389/fphys.2017.00353/full |
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