KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease

KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease

Redox imbalance and persistent inflammation are the underlying causes of most chronic diseases. Mammalian cells have evolved elaborate mechanisms for restoring redox homeostasis and resolving acute inflammatory responses. One prominent mechanism is that of inducing the expression of antioxidant, ant...

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Bibliographic Details
Main Authors: Sharadha Dayalan Naidu, Albena T. Dinkova-Kostova
Format: Article
Language:English
Published: The Royal Society 2020-06-01
Series:Open Biology
Subjects:
keap1
nrf2
cysteine
anti-inflammatory
antioxidant
redox
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200105

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