Circadian disruption and cancer- and treatment-related symptoms
Cancer patients experience a number of co-occurring side- and late-effects due to cancer and its treatment including fatigue, sleep difficulties, depressive symptoms, and cognitive impairment. These symptoms can impair quality of life and may persist long after treatment completion. Furthermore, the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1009064/full |
| _version_ | 1811197280060964864 |
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| author | Ali Amidi Ali Amidi Lisa M. Wu Lisa M. Wu Lisa M. Wu Lisa M. Wu |
| author_facet | Ali Amidi Ali Amidi Lisa M. Wu Lisa M. Wu Lisa M. Wu Lisa M. Wu |
| author_sort | Ali Amidi |
| collection | DOAJ |
| description | Cancer patients experience a number of co-occurring side- and late-effects due to cancer and its treatment including fatigue, sleep difficulties, depressive symptoms, and cognitive impairment. These symptoms can impair quality of life and may persist long after treatment completion. Furthermore, they may exacerbate each other’s intensity and development over time. The co-occurrence and interdependent nature of these symptoms suggests a possible shared underlying mechanism. Thus far, hypothesized mechanisms that have been purported to underlie these symptoms include disruptions to the immune and endocrine systems. Recently circadian rhythm disruption has emerged as a related pathophysiological mechanism underlying cancer- and cancer-treatment related symptoms. Circadian rhythms are endogenous biobehavioral cycles lasting approximately 24 hours in humans and generated by the circadian master clock – the hypothalamic suprachiasmatic nucleus. The suprachiasmatic nucleus orchestrates rhythmicity in a wide range of bodily functions including hormone levels, body temperature, immune response, and rest-activity behaviors. In this review, we describe four common approaches to the measurement of circadian rhythms, highlight key research findings on the presence of circadian disruption in cancer patients, and provide a review of the literature on associations between circadian rhythm disruption and cancer- and treatment-related symptoms. Implications for future research and interventions will be discussed. |
| first_indexed | 2024-04-12T01:11:27Z |
| format | Article |
| id | doaj.art-c5ad522b2388424babd511e57844d2c4 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T01:11:27Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-c5ad522b2388424babd511e57844d2c42022-12-22T03:54:05ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-10-011210.3389/fonc.2022.10090641009064Circadian disruption and cancer- and treatment-related symptomsAli Amidi0Ali Amidi1Lisa M. Wu2Lisa M. Wu3Lisa M. Wu4Lisa M. Wu5Unit for Psycho-Oncology and Health Psychology, Department of Psychology and Behavioural Sciences, Aarhus University, Aarhus, DenmarkSleep and Circadian Psychology Research Group, Department of Psychology and Behavioural Sciences, Aarhus University, Aarhus, DenmarkUnit for Psycho-Oncology and Health Psychology, Department of Psychology and Behavioural Sciences, Aarhus University, Aarhus, DenmarkSleep and Circadian Psychology Research Group, Department of Psychology and Behavioural Sciences, Aarhus University, Aarhus, DenmarkAarhus Institute of Advanced Studies, Aarhus University, Aarhus, DenmarkDepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesCancer patients experience a number of co-occurring side- and late-effects due to cancer and its treatment including fatigue, sleep difficulties, depressive symptoms, and cognitive impairment. These symptoms can impair quality of life and may persist long after treatment completion. Furthermore, they may exacerbate each other’s intensity and development over time. The co-occurrence and interdependent nature of these symptoms suggests a possible shared underlying mechanism. Thus far, hypothesized mechanisms that have been purported to underlie these symptoms include disruptions to the immune and endocrine systems. Recently circadian rhythm disruption has emerged as a related pathophysiological mechanism underlying cancer- and cancer-treatment related symptoms. Circadian rhythms are endogenous biobehavioral cycles lasting approximately 24 hours in humans and generated by the circadian master clock – the hypothalamic suprachiasmatic nucleus. The suprachiasmatic nucleus orchestrates rhythmicity in a wide range of bodily functions including hormone levels, body temperature, immune response, and rest-activity behaviors. In this review, we describe four common approaches to the measurement of circadian rhythms, highlight key research findings on the presence of circadian disruption in cancer patients, and provide a review of the literature on associations between circadian rhythm disruption and cancer- and treatment-related symptoms. Implications for future research and interventions will be discussed.https://www.frontiersin.org/articles/10.3389/fonc.2022.1009064/fullcircadian rhythmscancersleepfatiguecognitive impairmentdepressed mood |
| spellingShingle | Ali Amidi Ali Amidi Lisa M. Wu Lisa M. Wu Lisa M. Wu Lisa M. Wu Circadian disruption and cancer- and treatment-related symptoms Frontiers in Oncology circadian rhythms cancer sleep fatigue cognitive impairment depressed mood |
| title | Circadian disruption and cancer- and treatment-related symptoms |
| title_full | Circadian disruption and cancer- and treatment-related symptoms |
| title_fullStr | Circadian disruption and cancer- and treatment-related symptoms |
| title_full_unstemmed | Circadian disruption and cancer- and treatment-related symptoms |
| title_short | Circadian disruption and cancer- and treatment-related symptoms |
| title_sort | circadian disruption and cancer and treatment related symptoms |
| topic | circadian rhythms cancer sleep fatigue cognitive impairment depressed mood |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1009064/full |
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