The Contribution of Dietary Fructose to Non-alcoholic Fatty Liver Disease
Fructose, especially industrial fructose (sucrose and high fructose corn syrup) is commonly used in all kinds of beverages and processed foods. Liver is the primary organ for fructose metabolism, recent studies suggest that excessive fructose intake is a driving force in non-alcoholic fatty liver di...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.783393/full |
| _version_ | 1818402533139283968 |
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| author | Siyu Yu Chunlin Li Guang Ji Li Zhang |
| author_facet | Siyu Yu Chunlin Li Guang Ji Li Zhang |
| author_sort | Siyu Yu |
| collection | DOAJ |
| description | Fructose, especially industrial fructose (sucrose and high fructose corn syrup) is commonly used in all kinds of beverages and processed foods. Liver is the primary organ for fructose metabolism, recent studies suggest that excessive fructose intake is a driving force in non-alcoholic fatty liver disease (NAFLD). Dietary fructose metabolism begins at the intestine, along with its metabolites, may influence gut barrier and microbiota community, and contribute to increased nutrient absorption and lipogenic substrates overflow to the liver. Overwhelming fructose and the gut microbiota-derived fructose metabolites (e.g., acetate, butyric acid, butyrate and propionate) trigger the de novo lipogenesis in the liver, and result in lipid accumulation and hepatic steatosis. Fructose also reprograms the metabolic phenotype of liver cells (hepatocytes, macrophages, NK cells, etc.), and induces the occurrence of inflammation in the liver. Besides, there is endogenous fructose production that expands the fructose pool. Considering the close association of fructose metabolism and NAFLD, the drug development that focuses on blocking the absorption and metabolism of fructose might be promising strategies for NAFLD. Here we provide a systematic discussion of the underlying mechanisms of dietary fructose in contributing to the development and progression of NAFLD, and suggest the possible targets to prevent the pathogenetic process. |
| first_indexed | 2024-12-14T08:09:52Z |
| format | Article |
| id | doaj.art-c5add71ffb0a4a7a84fe58ab1ebd8734 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-14T08:09:52Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-c5add71ffb0a4a7a84fe58ab1ebd87342022-12-21T23:10:06ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-11-011210.3389/fphar.2021.783393783393The Contribution of Dietary Fructose to Non-alcoholic Fatty Liver DiseaseSiyu YuChunlin LiGuang JiLi ZhangFructose, especially industrial fructose (sucrose and high fructose corn syrup) is commonly used in all kinds of beverages and processed foods. Liver is the primary organ for fructose metabolism, recent studies suggest that excessive fructose intake is a driving force in non-alcoholic fatty liver disease (NAFLD). Dietary fructose metabolism begins at the intestine, along with its metabolites, may influence gut barrier and microbiota community, and contribute to increased nutrient absorption and lipogenic substrates overflow to the liver. Overwhelming fructose and the gut microbiota-derived fructose metabolites (e.g., acetate, butyric acid, butyrate and propionate) trigger the de novo lipogenesis in the liver, and result in lipid accumulation and hepatic steatosis. Fructose also reprograms the metabolic phenotype of liver cells (hepatocytes, macrophages, NK cells, etc.), and induces the occurrence of inflammation in the liver. Besides, there is endogenous fructose production that expands the fructose pool. Considering the close association of fructose metabolism and NAFLD, the drug development that focuses on blocking the absorption and metabolism of fructose might be promising strategies for NAFLD. Here we provide a systematic discussion of the underlying mechanisms of dietary fructose in contributing to the development and progression of NAFLD, and suggest the possible targets to prevent the pathogenetic process.https://www.frontiersin.org/articles/10.3389/fphar.2021.783393/fullnon-alcoholic fatty liver disease (NAFLD)fructoseintestinal environmentde novo lipogenesisinflammation |
| spellingShingle | Siyu Yu Chunlin Li Guang Ji Li Zhang The Contribution of Dietary Fructose to Non-alcoholic Fatty Liver Disease Frontiers in Pharmacology non-alcoholic fatty liver disease (NAFLD) fructose intestinal environment de novo lipogenesis inflammation |
| title | The Contribution of Dietary Fructose to Non-alcoholic Fatty Liver Disease |
| title_full | The Contribution of Dietary Fructose to Non-alcoholic Fatty Liver Disease |
| title_fullStr | The Contribution of Dietary Fructose to Non-alcoholic Fatty Liver Disease |
| title_full_unstemmed | The Contribution of Dietary Fructose to Non-alcoholic Fatty Liver Disease |
| title_short | The Contribution of Dietary Fructose to Non-alcoholic Fatty Liver Disease |
| title_sort | contribution of dietary fructose to non alcoholic fatty liver disease |
| topic | non-alcoholic fatty liver disease (NAFLD) fructose intestinal environment de novo lipogenesis inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.783393/full |
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