Mechanical Compression of Human Airway Epithelial Cells Induces Release of Extracellular Vesicles Containing Tenascin C

Mechanical Compression of Human Airway Epithelial Cells Induces Release of Extracellular Vesicles Containing Tenascin C

Aberrant remodeling of the asthmatic airway is not well understood but is thought to be attributable in part to mechanical compression of airway epithelial cells. Here, we examine compression-induced expression and secretion of the extracellular matrix protein tenascin C (TNC) from well-differentiat...

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Bibliographic Details
Main Authors: Chimwemwe Mwase, Thien-Khoi N. Phung, Michael J. O’Sullivan, Jennifer A. Mitchel, Margherita De Marzio, Ayşe Kılıç, Scott T. Weiss, Jeffrey J. Fredberg, Jin-Ah Park
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cells
Subjects:
asthma
airway remodeling
bronchospasm
mechanical compression
airway epithelial cells
extracellular matrix
Online Access:https://www.mdpi.com/2073-4409/11/2/256

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