[3 + n] Cycloaddition Reactions: A Milestone Approach for Elaborating Pyridazine of Potential Interest in Medicinal Chemistry and Optoelectronics
During the last few decades, pyridazine derivatives have emerged as privileged structures in heterocyclic chemistry, both because of their excellent chemistry and because of their potential applications in medicinal chemistry and optoelectronics. This review is focused on the recent advances in [3 +...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/11/3359 |
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| author | Dorina Amariucai-Mantu Violeta Mangalagiu Ionel I. Mangalagiu |
| author_facet | Dorina Amariucai-Mantu Violeta Mangalagiu Ionel I. Mangalagiu |
| author_sort | Dorina Amariucai-Mantu |
| collection | DOAJ |
| description | During the last few decades, pyridazine derivatives have emerged as privileged structures in heterocyclic chemistry, both because of their excellent chemistry and because of their potential applications in medicinal chemistry and optoelectronics. This review is focused on the recent advances in [3 + n] cycloaddition reactions in the pyridazine series as well as their medicinal chemistry and optoelectronic applications over the last ten years. The stereochemistry and regiochemistry of the cycloaddition reactions are discussed. Applications in optoelectronics (in particular, as fluorescent materials and sensors) and medicinal chemistry (in particular, antimicrobials and anticancer) are also reviewed. |
| first_indexed | 2024-03-10T10:46:14Z |
| format | Article |
| id | doaj.art-c5b0875aec364baa853edd74a7b05ccc |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T10:46:14Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c5b0875aec364baa853edd74a7b05ccc2023-11-21T22:35:00ZengMDPI AGMolecules1420-30492021-06-012611335910.3390/molecules26113359[3 + n] Cycloaddition Reactions: A Milestone Approach for Elaborating Pyridazine of Potential Interest in Medicinal Chemistry and OptoelectronicsDorina Amariucai-Mantu0Violeta Mangalagiu1Ionel I. Mangalagiu2Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol 1st Bvd, 700506 Iasi, RomaniaCERNESIM Centre, Institute of Interdisciplinary Research, Alexandru Ioan Cuza University of Iasi, 11 Carol 1st Bvd, 700506 Iasi, RomaniaFaculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol 1st Bvd, 700506 Iasi, RomaniaDuring the last few decades, pyridazine derivatives have emerged as privileged structures in heterocyclic chemistry, both because of their excellent chemistry and because of their potential applications in medicinal chemistry and optoelectronics. This review is focused on the recent advances in [3 + n] cycloaddition reactions in the pyridazine series as well as their medicinal chemistry and optoelectronic applications over the last ten years. The stereochemistry and regiochemistry of the cycloaddition reactions are discussed. Applications in optoelectronics (in particular, as fluorescent materials and sensors) and medicinal chemistry (in particular, antimicrobials and anticancer) are also reviewed.https://www.mdpi.com/1420-3049/26/11/3359[3 + n] cycloaddition reactionsylidespyridazinestereochemistryregiochemistrymedicinal chemistry |
| spellingShingle | Dorina Amariucai-Mantu Violeta Mangalagiu Ionel I. Mangalagiu [3 + n] Cycloaddition Reactions: A Milestone Approach for Elaborating Pyridazine of Potential Interest in Medicinal Chemistry and Optoelectronics Molecules [3 + n] cycloaddition reactions ylides pyridazine stereochemistry regiochemistry medicinal chemistry |
| title | [3 + n] Cycloaddition Reactions: A Milestone Approach for Elaborating Pyridazine of Potential Interest in Medicinal Chemistry and Optoelectronics |
| title_full | [3 + n] Cycloaddition Reactions: A Milestone Approach for Elaborating Pyridazine of Potential Interest in Medicinal Chemistry and Optoelectronics |
| title_fullStr | [3 + n] Cycloaddition Reactions: A Milestone Approach for Elaborating Pyridazine of Potential Interest in Medicinal Chemistry and Optoelectronics |
| title_full_unstemmed | [3 + n] Cycloaddition Reactions: A Milestone Approach for Elaborating Pyridazine of Potential Interest in Medicinal Chemistry and Optoelectronics |
| title_short | [3 + n] Cycloaddition Reactions: A Milestone Approach for Elaborating Pyridazine of Potential Interest in Medicinal Chemistry and Optoelectronics |
| title_sort | 3 n cycloaddition reactions a milestone approach for elaborating pyridazine of potential interest in medicinal chemistry and optoelectronics |
| topic | [3 + n] cycloaddition reactions ylides pyridazine stereochemistry regiochemistry medicinal chemistry |
| url | https://www.mdpi.com/1420-3049/26/11/3359 |
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