Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties

Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties

Tyrosyl-DNA-phosphodiesterase 1 (TDP1) is a promising target for antitumor therapy; the use of TDP1 inhibitors with a topoisomerase 1 poison such as topotecan is a potential combination therapy. In this work, a novel series of 3,5-disubstituted thiazolidine-2,4-diones was synthesized and tested agai...

Full description

Bibliographic Details
Main Authors:	Dmitry I. Ivankin, Tatyana E. Kornienko, Marina A. Mikhailova, Nadezhda S. Dyrkheeva, Alexandra L. Zakharenko, Chigozie Achara, Jóhannes Reynisson, Victor M. Golyshev, Olga A. Luzina, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Series:	International Journal of Molecular Sciences
Subjects:	tyrosyl-DNA-phosphodiesterase 1 TDP1 inhibitors thiazolidine-2,4-dione derivatives
Online Access:	https://www.mdpi.com/1422-0067/24/4/3834

Similar Items

Usnic Acid Derivatives Inhibit DNA Repair Enzymes Tyrosyl-DNA Phosphodiesterases 1 and 2 and Act as Potential Anticancer Agents
by: Alexandra L. Zakharenko, et al.
Published: (2023-10-01)

New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1
by: Nadezhda S. Dyrkheeva, et al.
Published: (2021-10-01)

New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors
by: Aleksander S. Filimonov, et al.
Published: (2019-10-01)

New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition
by: Nadezhda S. Dyrkheeva, et al.
Published: (2021-07-01)

Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1
by: Irina V. Il’ina, et al.
Published: (2020-07-01)

Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan
by: Aldar A. Munkuev, et al.
Published: (2022-05-01)

In Vitro and In Silico Studies of Human Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition by Stereoisomeric Forms of Lipophilic Nucleosides: The Role of Carbohydrate Stereochemistry in Ligand-Enzyme Interactions
by: Nadezhda S. Dyrkheeva, et al.
Published: (2022-04-01)

Synthesis and Antimicrobial Activity of a New Series of Thiazolidine-2,4-diones Carboxamide and Amino Acid Derivatives
by: Rakia Abd Alhameed, et al.
Published: (2019-12-01)

Thiazolidin-4-Ones as a Promising Scaffold in the Development of Antibiofilm Agents—A Review
by: Nazar Trotsko
Published: (2023-12-01)

Novel group of tyrosyl-DNA-phosphodiesterase 1 inhibitors based on disaccharide nucleosides as drug prototypes for anti-cancer therapy
by: Anastasia O. Komarova, et al.
Published: (2018-01-01)

The Lipophilic Purine Nucleoside—Tdp1 Inhibitor—Enhances DNA Damage Induced by Topotecan In Vitro and Potentiates the Antitumor Effect of Topotecan In Vivo
by: Irina A. Chernyshova, et al.
Published: (2022-12-01)

New Dual Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 and 2 Based on Deoxycholic Acid: Design, Synthesis, Cytotoxicity, and Molecular Modeling
by: Oksana V. Salomatina, et al.
Published: (2024-01-01)

Synthesis and Antibacterial Activity of New Thiazolidine-2,4-dione-Based Chlorophenylthiosemicarbazone Hybrids
by: Nazar Trotsko, et al.
Published: (2018-04-01)

Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides
by: Alexandra L. Zakharenko, et al.
Published: (2020-08-01)

Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors
by: Elizaveta D. Gladkova, et al.
Published: (2021-03-01)

Synthesis and biological evaluation of chromone-thiazolidine-2,4-dione derivatives as potential α-glucosidase inhibitors
by: Yingying Zheng, et al.
Published: (2023-11-01)

Synthesis, SAR and in vitro therapeutic potentials of thiazolidine-2,4-diones
by: Sucheta, et al.
Published: (2018-12-01)

Enhancement of the Antitumor and Antimetastatic Effect of Topotecan and Normalization of Blood Counts in Mice with Lewis Carcinoma by Tdp1 Inhibitors—New Usnic Acid Derivatives
by: Tatyana E. Kornienko, et al.
Published: (2024-01-01)

Design, synthesis, in silico studies and biological evaluation of 5-((E)-4-((E)-(substituted aryl/alkyl)methyl)benzylidene)thiazolidine-2,4-dione derivatives
by: Harsh Kumar, et al.
Published: (2020-03-01)

Synthesis, Structural and Biological Studies of /3-(1, 3- benzothiazol-2-yl) - /4H- spiro[indole2,3-[1,3]thiazolidine]- 2,/4(1H) dion with Cr (III), Mn (II), Co (II), Ni (II), Cu (II), and Zn (II) ions
by: Rehab A.M. Al-Hasani, et al.
Published: (2011-11-01)

The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme
by: Elizaveta D. Gladkova, et al.
Published: (2020-09-01)

In Vitro and In Vivo Biological Evaluation of Indole-thiazolidine-2,4-dione Derivatives as Tyrosinase Inhibitors
by: Li Lu, et al.
Published: (2023-11-01)

Antifungal Thiazolidines: Synthesis and Biological Evaluation of Mycosidine Congeners
by: Igor B. Levshin, et al.
Published: (2022-05-01)

New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2
by: Oksana V. Salomatina, et al.
Published: (2021-12-01)

New Phenolic Derivatives of Thiazolidine-2,4-dione with Antioxidant and Antiradical Properties: Synthesis, Characterization, In Vitro Evaluation, and Quantum Studies
by: Gabriel Marc, et al.
Published: (2019-05-01)

(Z)-3-Butyl-5-(4-nitrobenzylidene)thiazolidine-2,4-dione
by: Md. Serajul Haque Faizi, et al.
Published: (2019-01-01)

Synthesis and antimicrobial activity of some new N-(aryl-oxo-alkyl)-5-arylidene-thiazolidine-2,4-diones
by: Stana Anca, et al.
Published: (2014-01-01)

In vivo anti-inflammatory, analgesic and antipyretic activities of novel thiazolidine-2,4-dione analogs derived from some classical NSAIDs
by: Wantana Reanmongkol, et al.
Published: (2013-02-01)

3-(2-Diisopropylaminoethyl)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione
by: Serhii Holota, et al.
Published: (2022-06-01)

Discovery of new thiazolidine-2,4-dione derivatives as potential VEGFR-2 inhibitors: In vitro and in silico studies
by: Ibrahim H. Eissa, et al.
Published: (2024-01-01)

Synthesis, computational study, and antibacterial activity of rhodanine and thiazolidine-2,4-dione scaffolds
by: Rozh Qasim Amin, et al.
Published: (2020-06-01)

Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1
by: Alexandra L. Zakharenko, et al.
Published: (2023-03-01)

Design and synthesis of bioactive compounds containing thiazolidine and thiazolidinone derivatives/
by: Fatma Mohamed A Abid, 1959-, author 644811, et al.
Published: (2022)

Novel Tdp1 Inhibitors Based on Adamantane Connected with Monoterpene Moieties via Heterocyclic Fragments
by: Aldar A. Munkuev, et al.
Published: (2021-05-01)

Transcriptomic Analysis of CRISPR/Cas9-Mediated PARP1-Knockout Cells under the Influence of Topotecan and TDP1 Inhibitor
by: Nadezhda S. Dyrkheeva, et al.
Published: (2023-03-01)

Thiazolidin-2,4-Dione Scaffold: An Insight into Recent Advances as Antimicrobial, Antioxidant, and Hypoglycemic Agents
by: Harsh Kumar, et al.
Published: (2022-10-01)

Design, Molecular Docking, Synthesis, Anticancer and Anti-Hyperglycemic Assessments of Thiazolidine-2,4-diones Bearing Sulfonylthiourea Moieties as Potent VEGFR-2 Inhibitors and PPARγ Agonists
by: Mohamed A. Abdelgawad, et al.
Published: (2022-02-01)

Computer-Aided Strategy on 5-(Substituted benzylidene) Thiazolidine-2,4-Diones to Develop New and Potent PTP1B Inhibitors: QSAR Modeling, Molecular Docking, Molecular Dynamics, PASS Predictions, and DFT Investigations
by: Nour-El Houda Derki, et al.
Published: (2024-02-01)

Crystal structures of two (Z)-2-(4-oxo-1,3-thiazolidin-2-ylidene)acetamides
by: Aleksei Galushchinskiy, et al.
Published: (2017-12-01)

Sinthetic study of some beta-aminoketones using thiazolidine as catalyst
by: Érica Cristina da Silva, et al.
Published: (2012-06-01)