Prevalence of Spontaneous Bacterial Peritonitis (SBP) in Hepatitis B (HBV), and Hepatitis C (HCV) Liver Cirrhosis: A Systematic Review and Meta-Analysis
Background and Aim: Spontaneous bacterial peritonitis (SBP) is a common infection in liver cirrhosis. This systematic review and meta-analysis provide detailed information on the prevalence of SBP among hepatitis B virus (HBV) and hepatitis C virus (HCV)-related liver cirrhosis globally. Methods: A...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/11/2/275 |
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| author | Kizito Eneye Bello Ahmad Adebayo Irekeola Sameer Badri Al-Mhanna Okolo Martin-Luther Oseni Adejo Patience Omebije Rafidah Hanim Shueb Nazri Mustaffa |
| author_facet | Kizito Eneye Bello Ahmad Adebayo Irekeola Sameer Badri Al-Mhanna Okolo Martin-Luther Oseni Adejo Patience Omebije Rafidah Hanim Shueb Nazri Mustaffa |
| author_sort | Kizito Eneye Bello |
| collection | DOAJ |
| description | Background and Aim: Spontaneous bacterial peritonitis (SBP) is a common infection in liver cirrhosis. This systematic review and meta-analysis provide detailed information on the prevalence of SBP among hepatitis B virus (HBV) and hepatitis C virus (HCV)-related liver cirrhosis globally. Methods: A systematic search for articles describing the prevalence of SBP in HBV and HCV-related cirrhosis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. Our search returned ten (10) eligible articles involving 1713 viral cirrhosis cases representing eight (8) countries. A meta-analysis was performed on our eligible studies using the random effect model. A protocol was registered with PROSPERO (CRD42022321790). Results: The pooled prevalence of SBP in HBV-associated cirrhosis had the highest estimate [8.0% (95% CI, 2.7–21.0%; <i>I</i><sup>2</sup> = 96.13%; <i>p</i> < 0.001)], followed by SBP in HCV-associated liver cirrhosis [4.0% (95% CI, 1.3%–11.5%; <i>I</i><sup>2</sup> = 88.99%; <i>p</i> < 0.001)]. China (61.8%, CI: 57.1–66.3%), the USA (50.0%, CI: 34.6–65.4%), and Holland (31.1%, CI: 21.6–42.5%) had the highest estimate for SBP in HBV associated liver cirrhosis, SBP in HCV associated liver cirrhosis and SBP in HBV + HCV associated liver cirrhosis respectively. There was a significant difference in the prevalence of SBP in viral hepatitis-associated liver cirrhosis with the year of sampling and method of SBP detection at <i>P</i> < 0.001. There was an increase in SBP incidence at the beginning of 2016 across the liver cirrhosis in this study. Conclusion: The findings of this review revealed a rise in the incidence of SBP in viral hepatitis over the last decade. The latter indicates a possible future rise in the global prevalence of SBP among HBV and HCV-related liver cirrhosis. |
| first_indexed | 2024-03-09T12:32:07Z |
| format | Article |
| id | doaj.art-c5b2d4ea88fc4d57b084c5051b27cdd3 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-09T12:32:07Z |
| publishDate | 2023-01-01 |
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| series | Healthcare |
| spelling | doaj.art-c5b2d4ea88fc4d57b084c5051b27cdd32023-11-30T22:28:42ZengMDPI AGHealthcare2227-90322023-01-0111227510.3390/healthcare11020275Prevalence of Spontaneous Bacterial Peritonitis (SBP) in Hepatitis B (HBV), and Hepatitis C (HCV) Liver Cirrhosis: A Systematic Review and Meta-AnalysisKizito Eneye Bello0Ahmad Adebayo Irekeola1Sameer Badri Al-Mhanna2Okolo Martin-Luther Oseni3Adejo Patience Omebije4Rafidah Hanim Shueb5Nazri Mustaffa6Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, MalaysiaDepartment of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, MalaysiaDepartment of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, MalaysiaDepartment of Microbiology, Faculty of Natural Science, Kogi State University (Prince Abubakar Audu University), Anyigba 1008, Kogi State, NigeriaDepartment of Microbiology, Faculty of Natural Science, Kogi State University (Prince Abubakar Audu University), Anyigba 1008, Kogi State, NigeriaDepartment of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, MalaysiaDepartment of Medicine, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 11800, Kelantan, MalaysiaBackground and Aim: Spontaneous bacterial peritonitis (SBP) is a common infection in liver cirrhosis. This systematic review and meta-analysis provide detailed information on the prevalence of SBP among hepatitis B virus (HBV) and hepatitis C virus (HCV)-related liver cirrhosis globally. Methods: A systematic search for articles describing the prevalence of SBP in HBV and HCV-related cirrhosis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. Our search returned ten (10) eligible articles involving 1713 viral cirrhosis cases representing eight (8) countries. A meta-analysis was performed on our eligible studies using the random effect model. A protocol was registered with PROSPERO (CRD42022321790). Results: The pooled prevalence of SBP in HBV-associated cirrhosis had the highest estimate [8.0% (95% CI, 2.7–21.0%; <i>I</i><sup>2</sup> = 96.13%; <i>p</i> < 0.001)], followed by SBP in HCV-associated liver cirrhosis [4.0% (95% CI, 1.3%–11.5%; <i>I</i><sup>2</sup> = 88.99%; <i>p</i> < 0.001)]. China (61.8%, CI: 57.1–66.3%), the USA (50.0%, CI: 34.6–65.4%), and Holland (31.1%, CI: 21.6–42.5%) had the highest estimate for SBP in HBV associated liver cirrhosis, SBP in HCV associated liver cirrhosis and SBP in HBV + HCV associated liver cirrhosis respectively. There was a significant difference in the prevalence of SBP in viral hepatitis-associated liver cirrhosis with the year of sampling and method of SBP detection at <i>P</i> < 0.001. There was an increase in SBP incidence at the beginning of 2016 across the liver cirrhosis in this study. Conclusion: The findings of this review revealed a rise in the incidence of SBP in viral hepatitis over the last decade. The latter indicates a possible future rise in the global prevalence of SBP among HBV and HCV-related liver cirrhosis.https://www.mdpi.com/2227-9032/11/2/275spontaneous bacterial peritonitishepatitis B virushepatitis C virusliver cirrhosisprevalenceand cancer |
| spellingShingle | Kizito Eneye Bello Ahmad Adebayo Irekeola Sameer Badri Al-Mhanna Okolo Martin-Luther Oseni Adejo Patience Omebije Rafidah Hanim Shueb Nazri Mustaffa Prevalence of Spontaneous Bacterial Peritonitis (SBP) in Hepatitis B (HBV), and Hepatitis C (HCV) Liver Cirrhosis: A Systematic Review and Meta-Analysis Healthcare spontaneous bacterial peritonitis hepatitis B virus hepatitis C virus liver cirrhosis prevalence and cancer |
| title | Prevalence of Spontaneous Bacterial Peritonitis (SBP) in Hepatitis B (HBV), and Hepatitis C (HCV) Liver Cirrhosis: A Systematic Review and Meta-Analysis |
| title_full | Prevalence of Spontaneous Bacterial Peritonitis (SBP) in Hepatitis B (HBV), and Hepatitis C (HCV) Liver Cirrhosis: A Systematic Review and Meta-Analysis |
| title_fullStr | Prevalence of Spontaneous Bacterial Peritonitis (SBP) in Hepatitis B (HBV), and Hepatitis C (HCV) Liver Cirrhosis: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Prevalence of Spontaneous Bacterial Peritonitis (SBP) in Hepatitis B (HBV), and Hepatitis C (HCV) Liver Cirrhosis: A Systematic Review and Meta-Analysis |
| title_short | Prevalence of Spontaneous Bacterial Peritonitis (SBP) in Hepatitis B (HBV), and Hepatitis C (HCV) Liver Cirrhosis: A Systematic Review and Meta-Analysis |
| title_sort | prevalence of spontaneous bacterial peritonitis sbp in hepatitis b hbv and hepatitis c hcv liver cirrhosis a systematic review and meta analysis |
| topic | spontaneous bacterial peritonitis hepatitis B virus hepatitis C virus liver cirrhosis prevalence and cancer |
| url | https://www.mdpi.com/2227-9032/11/2/275 |
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