Identification of α-isopropylmalate synthase mutants capable of overproducing L-leucine in Corynebacterium glutamicum

Identification of α-isopropylmalate synthase mutants capable of overproducing L-leucine in Corynebacterium glutamicum

The enzyme α-isopropylmalate synthase (α-IPMS) catalyzes the first step of L-leucine biosynthesis and is regulated via feedback inhibition by L-leucine. The gene of α-IPMS variant from strain ARTP-L04 was cloned and sequenced. Interestingly, amino acid mutations of Gly92Asp, Ile162Val, Arg494His and...

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Bibliographic Details
Main Authors: Yan-Feng Guo, Yu Lu, Lei Song, Jinghua Liu, Yi-Lei Wang, Guo-Qing Meng
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:All Life
Subjects:
l-leucine
α-isopropylmalate synthase
feedback inhibition
corynebacterium glutamicum
Online Access:http://dx.doi.org/10.1080/26895293.2023.2211237

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