Limited Effects of an eIF2αS51A Allele on Neurological Impairments in the 5xFAD Mouse Model of Alzheimer’s Disease
Alzheimer’s disease (AD) has been associated with increased phosphorylation of the translation initiation factor 2α (eIF2α) at serine 51. Increased phosphorylation of eIF2α alters translational control and may thereby have adverse effects on synaptic plasticity, learning, and memory. To analyze if i...
| Hlavní autoři: | , , , , , , , , , , , , , |
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| Médium: | Článek |
| Jazyk: | English |
| Vydáno: |
Hindawi Limited
2015-01-01
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| Edice: | Neural Plasticity |
| On-line přístup: | http://dx.doi.org/10.1155/2015/825157 |