Identification of Pol IV and RDR2-dependent precursors of 24 nt siRNAs guiding de novo DNA methylation in Arabidopsis

Identification of Pol IV and RDR2-dependent precursors of 24 nt siRNAs guiding de novo DNA methylation in Arabidopsis

In Arabidopsis thaliana, abundant 24 nucleotide small interfering RNAs (24 nt siRNA) guide the cytosine methylation and silencing of transposons and a subset of genes. 24 nt siRNA biogenesis requires nuclear RNA polymerase IV (Pol IV), RNA-dependent RNA polymerase 2 (RDR2) and DICER-like 3 (DCL3). H...

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Bibliographic Details
Main Authors: Todd Blevins, Ram Podicheti, Vibhor Mishra, Michelle Marasco, Jing Wang, Doug Rusch, Haixu Tang, Craig S Pikaard
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-10-01
Series:eLife
Subjects:
RNA silencing
epigenetic
RNA-directed DNA methylation
noncoding RNA
RNA interference
transcription
Online Access:https://elifesciences.org/articles/09591

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