Multihost Transmission of Schistosoma mansoni in Senegal, 2015–2018
In West Africa, Schistosoma spp. are capable of infecting multiple definitive hosts, a lifecycle feature that may complicate schistosomiasis control. We characterized the evolutionary relationships among multiple Schistosoma mansoni isolates collected from snails (intermediate hosts), humans (defini...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2020-06-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/26/6/20-0107_article |
| _version_ | 1811198554869334016 |
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| author | Stefano Catalano Elsa Léger Cheikh B. Fall Anna Borlase Samba D. Diop Duncan Berger Bonnie L. Webster Babacar Faye Nicolas D. Diouf David Rollinson Mariama Sène Khalilou Bâ Joanne P. Webster |
| author_facet | Stefano Catalano Elsa Léger Cheikh B. Fall Anna Borlase Samba D. Diop Duncan Berger Bonnie L. Webster Babacar Faye Nicolas D. Diouf David Rollinson Mariama Sène Khalilou Bâ Joanne P. Webster |
| author_sort | Stefano Catalano |
| collection | DOAJ |
| description | In West Africa, Schistosoma spp. are capable of infecting multiple definitive hosts, a lifecycle feature that may complicate schistosomiasis control. We characterized the evolutionary relationships among multiple Schistosoma mansoni isolates collected from snails (intermediate hosts), humans (definitive hosts), and rodents (definitive hosts) in Senegal. On a local scale, diagnosis of S. mansoni infection ranged 3.8%–44.8% in school-aged children, 1.7%–52.6% in Mastomys huberti mice, and 1.8%–7.1% in Biomphalaria pfeifferi snails. Our phylogenetic framework confirmed the presence of multiple S. mansoni lineages that could infect both humans and rodents; divergence times of these lineages varied (0.13–0.02 million years ago). We propose that extensive movement of persons across West Africa might have contributed to the establishment of these various multihost S. mansoni clades. High S. mansoni prevalence in rodents at transmission sites frequented by humans further highlights the implications that alternative hosts could have on future public health interventions. |
| first_indexed | 2024-04-12T01:33:28Z |
| format | Article |
| id | doaj.art-c5b8901b056a444faba66dc8aee8abe9 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-12T01:33:28Z |
| publishDate | 2020-06-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-c5b8901b056a444faba66dc8aee8abe92022-12-22T03:53:25ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592020-06-012661234124210.3201/eid2606.200107Multihost Transmission of Schistosoma mansoni in Senegal, 2015–2018Stefano CatalanoElsa LégerCheikh B. FallAnna BorlaseSamba D. DiopDuncan BergerBonnie L. WebsterBabacar FayeNicolas D. DioufDavid RollinsonMariama SèneKhalilou BâJoanne P. WebsterIn West Africa, Schistosoma spp. are capable of infecting multiple definitive hosts, a lifecycle feature that may complicate schistosomiasis control. We characterized the evolutionary relationships among multiple Schistosoma mansoni isolates collected from snails (intermediate hosts), humans (definitive hosts), and rodents (definitive hosts) in Senegal. On a local scale, diagnosis of S. mansoni infection ranged 3.8%–44.8% in school-aged children, 1.7%–52.6% in Mastomys huberti mice, and 1.8%–7.1% in Biomphalaria pfeifferi snails. Our phylogenetic framework confirmed the presence of multiple S. mansoni lineages that could infect both humans and rodents; divergence times of these lineages varied (0.13–0.02 million years ago). We propose that extensive movement of persons across West Africa might have contributed to the establishment of these various multihost S. mansoni clades. High S. mansoni prevalence in rodents at transmission sites frequented by humans further highlights the implications that alternative hosts could have on future public health interventions.https://wwwnc.cdc.gov/eid/article/26/6/20-0107_articleSchistosomazoonosesRodentiaSchistosoma mansoniWest AfricaSenegal |
| spellingShingle | Stefano Catalano Elsa Léger Cheikh B. Fall Anna Borlase Samba D. Diop Duncan Berger Bonnie L. Webster Babacar Faye Nicolas D. Diouf David Rollinson Mariama Sène Khalilou Bâ Joanne P. Webster Multihost Transmission of Schistosoma mansoni in Senegal, 2015–2018 Emerging Infectious Diseases Schistosoma zoonoses Rodentia Schistosoma mansoni West Africa Senegal |
| title | Multihost Transmission of Schistosoma mansoni in Senegal, 2015–2018 |
| title_full | Multihost Transmission of Schistosoma mansoni in Senegal, 2015–2018 |
| title_fullStr | Multihost Transmission of Schistosoma mansoni in Senegal, 2015–2018 |
| title_full_unstemmed | Multihost Transmission of Schistosoma mansoni in Senegal, 2015–2018 |
| title_short | Multihost Transmission of Schistosoma mansoni in Senegal, 2015–2018 |
| title_sort | multihost transmission of schistosoma mansoni in senegal 2015 2018 |
| topic | Schistosoma zoonoses Rodentia Schistosoma mansoni West Africa Senegal |
| url | https://wwwnc.cdc.gov/eid/article/26/6/20-0107_article |
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