Disruption of 5-HT2A receptor-PDZ protein interactions alleviates mechanical hypersensitivity in carrageenan-induced inflammation in rats.

Disruption of 5-HT2A receptor-PDZ protein interactions alleviates mechanical hypersensitivity in carrageenan-induced inflammation in rats.

Despite common pathophysiological mechanisms, inflammatory and neuropathic pain do not respond equally to the analgesic effect of antidepressants, except for selective serotonin reuptake inhibitors (SSRIs), which show a limited efficacy in both conditions. We previously demonstrated that an interfer...

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Main Authors: Anne-Sophie Wattiez, Xavier Pichon, Amandine Dupuis, Alejandro Hernández, Anne-Marie Privat, Youssef Aissouni, Maryse Chalus, Teresa Pelissier, Alain Eschalier, Philippe Marin, Christine Courteix
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3776748?pdf=render

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