Gender-related differences on outcome following transcatheter mitral valve repair (TMVR): a systematic review and meta-analysis
Abstract Background The effect of gender on patients with mitral valve regurgitation (MR) undergoing transcatheter mitral valve repair (TMVR) remains to be defined. The aim of the present study is a comprehensive meta-analysis of studies that investigate differences between men and women after TMVR....
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Journal of Cardiothoracic Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13019-023-02123-6 |
| _version_ | 1797945767727464448 |
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| author | Kang Yi Jie Gao Wen-Xin Wang Yu-Hu Ma Wei Wang Shao E. He Xiao-Min Xu Peng-Fei Li Tao You |
| author_facet | Kang Yi Jie Gao Wen-Xin Wang Yu-Hu Ma Wei Wang Shao E. He Xiao-Min Xu Peng-Fei Li Tao You |
| author_sort | Kang Yi |
| collection | DOAJ |
| description | Abstract Background The effect of gender on patients with mitral valve regurgitation (MR) undergoing transcatheter mitral valve repair (TMVR) remains to be defined. The aim of the present study is a comprehensive meta-analysis of studies that investigate differences between men and women after TMVR. Methods A systematic literature search was carried out on eight databases to collect all relevant studies on gender-related outcomes of TMVR before March 1, 2021. The main outcomes of interest were mortality, cardiac function, MR class and other complications. Results A total of eight literatures were included, all of which were retrospective observational studies. Compared to women patients, men had lower postoperative New York Heart Association (NYHA) class (OR = 1.53, 95%CI [1.23, 1.91], P = 0.0001) and higher incidence of postoperative acute kidney injury (AKI) (OR = 1.25, 95%CI [1.16, 1.34], P < 0.05). There were no significant difference on mortality in 30 days (OR = 0.95, 95%CI [0.81, 1.11], P = 0.53) and in 2 years (OR = 0.99, 95%CI [0.75, 1.30], P = 0.93), mitral valve regurgitation (MR) class (OR = 1.30, 95%CI [0.97, 1.75], P = 0.08) and incidence of myocardial infarction (MI) (OR = 0.88, 95%CI [0.65, 1.18], P = 0.38), stroke (OR = 0.80, 95%CI [0.63, 1.02], P = 0.08) and bleeding in hospital (OR = 0.84, 95%CI [0.59, 1.19], P = 0.32). Conclusions Our meta-analysis demonstrates that men undergoing TMVR have worse preoperative diseases (diabetes mellitus, coronary artery disease, renal failure and myocardial infarction) while they have superior postoperative NYHA class at one-year. There are no significantly difference in other indexes between men and women. |
| first_indexed | 2024-04-10T21:00:20Z |
| format | Article |
| id | doaj.art-c5ba4ddb9f9e4194b05204a1c86fe0e3 |
| institution | Directory Open Access Journal |
| issn | 1749-8090 |
| language | English |
| last_indexed | 2024-04-10T21:00:20Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj.art-c5ba4ddb9f9e4194b05204a1c86fe0e32023-01-22T12:24:52ZengBMCJournal of Cardiothoracic Surgery1749-80902023-01-0118111110.1186/s13019-023-02123-6Gender-related differences on outcome following transcatheter mitral valve repair (TMVR): a systematic review and meta-analysisKang Yi0Jie Gao1Wen-Xin Wang2Yu-Hu Ma3Wei Wang4Shao E. He5Xiao-Min Xu6Peng-Fei Li7Tao You8Department of Cardiovascular Surgery, Gansu Province, Gansu Provincial HospitalGansu International Scientific and Technological Cooperation Base of Diagnosis and Treatment of Congenital Heart DiseaseGansu International Scientific and Technological Cooperation Base of Diagnosis and Treatment of Congenital Heart DiseaseDepartment of Neurosurgery, West China Hospital of Sichuan UniversityDepartment of Cardiac Surgery, The First Hospital of China Medical UniversityGansu International Scientific and Technological Cooperation Base of Diagnosis and Treatment of Congenital Heart DiseaseGansu International Scientific and Technological Cooperation Base of Diagnosis and Treatment of Congenital Heart DiseaseGansu International Scientific and Technological Cooperation Base of Diagnosis and Treatment of Congenital Heart DiseaseDepartment of Cardiovascular Surgery, Gansu Province, Gansu Provincial HospitalAbstract Background The effect of gender on patients with mitral valve regurgitation (MR) undergoing transcatheter mitral valve repair (TMVR) remains to be defined. The aim of the present study is a comprehensive meta-analysis of studies that investigate differences between men and women after TMVR. Methods A systematic literature search was carried out on eight databases to collect all relevant studies on gender-related outcomes of TMVR before March 1, 2021. The main outcomes of interest were mortality, cardiac function, MR class and other complications. Results A total of eight literatures were included, all of which were retrospective observational studies. Compared to women patients, men had lower postoperative New York Heart Association (NYHA) class (OR = 1.53, 95%CI [1.23, 1.91], P = 0.0001) and higher incidence of postoperative acute kidney injury (AKI) (OR = 1.25, 95%CI [1.16, 1.34], P < 0.05). There were no significant difference on mortality in 30 days (OR = 0.95, 95%CI [0.81, 1.11], P = 0.53) and in 2 years (OR = 0.99, 95%CI [0.75, 1.30], P = 0.93), mitral valve regurgitation (MR) class (OR = 1.30, 95%CI [0.97, 1.75], P = 0.08) and incidence of myocardial infarction (MI) (OR = 0.88, 95%CI [0.65, 1.18], P = 0.38), stroke (OR = 0.80, 95%CI [0.63, 1.02], P = 0.08) and bleeding in hospital (OR = 0.84, 95%CI [0.59, 1.19], P = 0.32). Conclusions Our meta-analysis demonstrates that men undergoing TMVR have worse preoperative diseases (diabetes mellitus, coronary artery disease, renal failure and myocardial infarction) while they have superior postoperative NYHA class at one-year. There are no significantly difference in other indexes between men and women.https://doi.org/10.1186/s13019-023-02123-6Mitral valve regurgitationTranscatheter mitral valve repairMitraClipGender differencesMeta-analysisSystematic reviews |
| spellingShingle | Kang Yi Jie Gao Wen-Xin Wang Yu-Hu Ma Wei Wang Shao E. He Xiao-Min Xu Peng-Fei Li Tao You Gender-related differences on outcome following transcatheter mitral valve repair (TMVR): a systematic review and meta-analysis Journal of Cardiothoracic Surgery Mitral valve regurgitation Transcatheter mitral valve repair MitraClip Gender differences Meta-analysis Systematic reviews |
| title | Gender-related differences on outcome following transcatheter mitral valve repair (TMVR): a systematic review and meta-analysis |
| title_full | Gender-related differences on outcome following transcatheter mitral valve repair (TMVR): a systematic review and meta-analysis |
| title_fullStr | Gender-related differences on outcome following transcatheter mitral valve repair (TMVR): a systematic review and meta-analysis |
| title_full_unstemmed | Gender-related differences on outcome following transcatheter mitral valve repair (TMVR): a systematic review and meta-analysis |
| title_short | Gender-related differences on outcome following transcatheter mitral valve repair (TMVR): a systematic review and meta-analysis |
| title_sort | gender related differences on outcome following transcatheter mitral valve repair tmvr a systematic review and meta analysis |
| topic | Mitral valve regurgitation Transcatheter mitral valve repair MitraClip Gender differences Meta-analysis Systematic reviews |
| url | https://doi.org/10.1186/s13019-023-02123-6 |
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